DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and fbl-1

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_001293878.1 Gene:fbl-1 / 177788 WormBaseID:WBGene00001403 Length:751 Species:Caenorhabditis elegans


Alignment Length:794 Identity:217/794 - (27%)
Similarity:292/794 - (36%) Gaps:268/794 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 TFLDNNCGEDNGGCAHICKRLLYPDENQPIN-----------KCDCREGYTLDPNDYASCLDIDE 295
            :.|||.|  |:|  ..|.|.    :|:.|.|           .|||             ||...:
 Worm    60 SLLDNAC--DSG--TDIAKE----EESCPSNINILGGGLKKECCDC-------------CLLAKD 103

  Fly   296 CLESNGGCSEICENLPGEYKCSCQEGYYLDESGKSCVDINECANPEL------------------ 342
            .|..|..|.     .|..:...|...:            |:|.|.::                  
 Worm   104 LLNRNEPCV-----APVGFSAGCLRSF------------NKCCNGDIEITHASEIITGRPLNDPH 151

  Fly   343 ---------SSNCQGACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSESQPAGKTCN 398
                     ||:|:..|.:..|               |.||                    .:|.
 Worm   152 VLHLGDRCASSHCEHLCHDRGG---------------EKVE--------------------CSCR 181

  Fly   399 SGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQK--CENTIGSFRCTCVEGYHLLEDQRSCALD 461
            |||.|:.||..|.|.|||       |...:.|.|.  |.||||.:.|          .:|...|.
 Worm   182 SGFDLAPDGMACVDRNEC-------LTRQSPCTQSEDCVNTIGGYIC----------QRRISRLV 229

  Fly   462 SCTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKCSPGTC 526
            ......|...|..|...:......|.||                                     
 Worm   230 PHRHRANRIGNAPRRMRDDPYSRAGEYR------------------------------------- 257

  Fly   527 LASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCS--HTCQNTPGGYQC---QCPEGLNLVE 586
            .||:.||.|.  ||.|:..:...|.|:|||...:|.|.  :.|:||.|.|:|   :|.:|     
 Worm   258 EASQANTEFG--CPMGWLFQHGHCVDVDECNLGSHDCGPLYQCRNTQGSYRCDAKKCGDG----- 315

  Fly   587 EYTCLAENLCEVNN---NGCEQICLTARGGVCACREGFRLSADGKSCEDVDECLV-NNGGCQQVC 647
                      |:.|   ..|..|         .|..|: ...:| .|.|:|||:. :|.|..:.|
 Worm   316 ----------ELQNPMTGECTSI---------TCPNGY-YPKNG-MCNDIDECVTGHNCGAGEEC 359

  Fly   648 RNLPGSYGC-----ICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPG 707
            .|.|||:.|     :||.|||   ::|..|:|.|::||.|   |....|.|.||.|:|.|.|.||
 Worm   360 VNTPGSFRCQQKGNLCAHGYE---VNGATGFCEDVNECQQ---GVCGSMECINLPGTYKCKCGPG 418

  Fly   708 YALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDEC-SLANGNC--SHFCQNEPGGFQCACPL 769
            |..                      ..:...|.|:||| ..|...|  |..|.|..|.|:|.|..
 Worm   419 YEF----------------------NDAKKRCEDVDECIKFAGHVCDLSAECINTIGSFECKCKP 461

  Fly   770 GYALSEDMRTCQDIDECLDSNGQCSQLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNC 834
            |:.|:.|.|.|:|::||......|.|.|:|.||.:.|.|:.||.|.|||..|.||||||...|:.
 Worm   462 GFQLASDGRRCEDVNECTTGIAACEQKCVNIPGSYQCICDRGFALGPDGTKCEDIDECSIWAGSG 526

  Fly   835 SDI----CINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCSHECINKAGTFEC---GCP 892
            :|:    |||..|::.|.|..||::..|..:|:||||||.....|....|:|..|:|:|   .||
 Worm   527 NDLCMGGCINTKGSYLCQCPPGYKIQPDGRTCVDVDECAMGECAGSDKVCVNTLGSFKCHSIDCP 591

  Fly   893 LGYI---LNDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDECQKQNGGCSH 954
            ..||   ||.:..:..|:..|.|       :.|:.:.....|...|..:.|.|.         ||
 Worm   592 TNYIHDSLNKNRCNRQPSACGLP-------EECSKVPLFLTYQFISLARAVPIS---------SH 640

  Fly   955 RCSNTEGSFKCSCP 968
            |.:.|  .||.|.|
 Worm   641 RPAIT--LFKVSAP 652

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 5/34 (15%)
cEGF 396..415 CDD:463661 9/18 (50%)
FXa_inhibition 425..458 CDD:464251 9/34 (26%)
FXa_inhibition 476..505 CDD:464251 3/28 (11%)
EGF_CA 552..>581 CDD:214542 13/33 (39%)
FXa_inhibition 596..630 CDD:464251 7/36 (19%)
FXa_inhibition 636..>664 CDD:464251 13/33 (39%)
EGF_CA 676..711 CDD:214542 16/34 (47%)
FXa_inhibition 745..780 CDD:464251 14/37 (38%)
FXa_inhibition 786..821 CDD:464251 15/34 (44%)
vWFA <821..861 CDD:469594 18/43 (42%)
FXa_inhibition 874..904 CDD:464251 12/35 (34%)
FXa_inhibition 945..980 CDD:464251 8/24 (33%)
PTZ00449 <1017..>1098 CDD:185628
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
HYR 1468..1536 CDD:460572
fbl-1NP_001293878.1 EGF_CA 343..380 CDD:214542 15/36 (42%)
EGF_CA 390..429 CDD:214542 16/63 (25%)
EGF_CA 430..462 CDD:429571 13/31 (42%)
vWFA <469..510 CDD:469594 17/40 (43%)
EGF_CA 515..559 CDD:214542 17/43 (40%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.