DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and mua-3

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_001022674.1 Gene:mua-3 / 176430 WormBaseID:WBGene00003482 Length:3767 Species:Caenorhabditis elegans


Alignment Length:1891 Identity:404/1891 - (21%)
Similarity:613/1891 - (32%) Gaps:630/1891 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 SSAKILPPEINHGRVSVFDRRRRGKKVFLVAFFVCD-----DNYDFENGI-------SEMFCSNQ 104
            ||...|||    |||.........:|..||  |:.|     .:|.|:|.:       .|:|    
 Worm  1207 SSNANLPP----GRVCTVQTTCPKQKTDLV--FLIDGSGSIGSYVFKNEVLRFVREFVELF---- 1261

  Fly   105 KWVDEIPTCIPQLNFEEHDEKV--GYDLEDYSD---------ETVPNDYV-----ENSDIDEDDD 153
                ||.....::...::.:::  .:||:.|.|         ||   .|:     ..:.|.....
 Worm  1262 ----EIGRSKTRVGLIQYSDQIRHEFDLDQYGDRDSLLKGISET---QYLTGLTRTGAAIQHMVQ 1319

  Fly   154 EEVSEREPPPPPPPPV-------VDG---------ADSKPEPQIVIEIN------DDHANEVVES 196
            |..|||....|....:       .||         |||..:    :.||      .||   |:.|
 Worm  1320 EGFSERRGARPQQSDIARVAIILTDGRSQDNVTGPADSARK----LSINTFAIGVTDH---VLAS 1377

  Fly   197 E-PALAETETE----NEVLENETPLKAEVQTDVLNSSNASVKVTNDPYEP-------TFLDNNCG 249
            | .::|.:...    ::..:.:|.|::.:|.....|.......:.|...|       ..|:.:|.
 Worm  1378 ELESIAGSPNRWFYVDKFKDLDTRLRSMIQKAACPSPTKQETPSEDVCNPRTQTGCDRSLNEHCA 1442

  Fly   250 EDNGGCAHICKRLLYPDENQPINKCDCREGYTLDP------NDYASCLDIDECLESNGGCSEICE 308
            .:||               :|  :|.|.||:|..|      .|..:...|..|:     ..|.|:
 Worm  1443 VENG---------------RP--RCVCPEGFTRHPFTRVCGGDLCNPQLITSCI-----FPEECQ 1485

  Fly   309 NLP-GEYKCSCQEGYYLDESGKSCVDINEC-ANPELSSNCQGA------------------CENL 353
            ..| ..::|||.|||..|.....||.:.|. .:|:..:||...                  ||.|
 Worm  1486 ITPYKNFRCSCPEGYNRDYRSGFCVSVKEVQISPQHDANCHNGGVRCSENERCTNDGSDWFCECL 1550

  Fly   354 PGSYR-----CVEPLEENPEITEVVENPIEKTNEVPVNVSESQ---PAGK--TCNSGFQLSADG- 407
            ||..|     |..|...||            .:.:..:|.:.|   |.|.  ||..|....... 
 Worm  1551 PGFERIRNGQCAYPGSCNP------------NDPMSCDVRKRQQCLPRGNIYTCQCGRNEKRHPI 1603

  Fly   408 TDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGY--------------------HLL 452
            ||....||| :.|..|.|.:|    :|.:|..|:.|.|..|:                    ..|
 Worm  1604 TDICLKNEC-LTGEHDCDRSA----RCIDTDESYICACQSGFIDHSPNPSERPGRVCVALQNECL 1663

  Fly   453 EDQRSCALDS-CTDLE----------------------------------NPQLNR-TRCAHECQ 481
            :....|:.:: |||.|                                  ||:||: .|.|| |.
 Worm  1664 DGSNRCSPNALCTDTEEGYVCRCKSGFVDYSPNPQTFPGMVCKELVNECTNPRLNQCDRNAH-CI 1727

  Fly   482 DLPEGSYRCVCPKGYELSEDQHSCLVQESP---CSTEKGVEKCSPG--------TCLASEDNTSF 535
            |..|| |.|:|..|: :..|:..     :|   |...|..:|||||        .|:...|: .:
 Worm  1728 DTIEG-YSCICKPGF-VDMDEFG-----NPGRRCEQIKTNDKCSPGKNDCDRNARCIQIGDD-DY 1784

  Fly   536 SCICPTGYRSEAFSCQD--------IDECAEDT-HLCSH----TCQNTPGGYQCQCPEG-LNLVE 586
            ||.||.|::.::.|...        |.||...| :.|..    .|.:|..||.|:|.:| |::..
 Worm  1785 SCACPPGFKDKSPSSSRPGRLCIPVIPECDNPTLNDCDSPDRAVCTDTDDGYMCRCRQGFLDISP 1849

  Fly   587 EYTCLAENLCEVNNNGCE---QICLTAR-GGVC-------ACREGF--------RLSADGKSCED 632
            ..:.....||:...|.|.   ..|  || ||:|       .||...        |::..|:.|:.
 Worm  1850 SISVKPGRLCKPLQNECALGIDDC--ARDGGICEDNPDSFTCRCAMNYLDVSFDRVTRPGRKCKR 1912

  Fly   633 -VDECLVNNGGCQQ--VCRNLPGSYGCICAAGYELLKLDGI----RGYCFDIDECSQRTHGCSDQ 690
             ::||......|.:  .|.:...||.|.|...:..|..|.:    |.....|:||:...|.||..
 Worm  1913 LINECQTGQNDCSEEATCTDTEDSYICACPQSHIDLSPDTVNRPGRRCLMRINECTSNRHDCSPN 1977

  Fly   691 MLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLD--IDECSLANGNC- 752
            ..|.:...||.|.|                ...|:.:|..|.......|..  :|||.....:| 
 Worm  1978 ADCIDTPESYKCRC----------------RDDFVDESPDSSRRPGRICRPALVDECRTGKHDCH 2026

  Fly   753 -SHFCQNEPGGFQCACPLGYA------LSEDMRTCQ-----DIDEC-LDSNGQC----SQLCLNQ 800
             :..||:.|.|:.|.|...:.      .|...|.||     ...|| ||...||    :::|...
 Worm  2027 VNAICQDLPQGYTCQCSADFVDVSPHRASHPGRLCQPRPTPPPPECRLDGGNQCKVHLNEVCRLM 2091

  Fly   801 PGGFACACETGFELTPDGFGCADIDEC----SQDYGNCSDICINLLGTHACACERGYELAKDK-- 859
            .|...|:|...::....| .|:.|:||    ..|....:| ||:.:..:.|.|..|::...|:  
 Worm  2092 GGEPKCSCPVNYQRDSSG-SCSIINECLFTQLNDCHTAAD-CIDQVQGYTCQCRDGFKDIGDRRR 2154

  Fly   860 --LSCLD-VDECAGLLSGGCSHE---CINKAGTFECGCPLGYILNDDGRS---CSPALVGCPPGT 915
              ..|.. |:||.......| |:   ||:....:||.|..|::.:..||.   |......|...:
 Worm  2155 PGRMCKPMVNECQYPHLNDC-HQNAACIDLEEGYECKCNQGFMDHSHGRPGRICKQLTNECLRPS 2218

  Fly   916 QRSADGCAP-IECNPGYTLGSDDKCVDID--------ECQKQNGGCSH----------RCSNTEG 961
            ..|.|..|. |:...||.....|..:|:.        .|::....|::          ||.:|..
 Worm  2219 LNSCDRNARCIDKEEGYECECRDGFIDVSPSPTLKGRACRELVNECANSRLNDCDKNARCKDTMD 2283

  Fly   962 SFKCSCP------------PGYELDSDQKTC-QDIDECDQDKTSC-ITGTCINEIGGFRCEFPKF 1012
            |::|.||            ||       :.| ..|:||:.....| .:.||.:....|.||.|  
 Worm  2284 SYECDCPVNSKDISPSPSFPG-------RVCLMFINECESGVHDCDPSATCRDNEQSFTCECP-- 2339

  Fly  1013 PVLPEIPTASSLPESPKIELKTPKYPDFTELSNEIPENPKKPAEFDYPEPKFPSLPKWEGLPKLP 1077
                                           |..:..:|.|.|                      
 Worm  2340 -------------------------------SGFVDRSPNKHA---------------------- 2351

  Fly  1078 PLADIPTSKAPVPLRPEVPKSLWVNQLQPRDLCPRF-QAPRNGKSHCNRYRHKQKLFYYSRCRIS 1141
                                       :|..:|.:. ...|.|:..|:.:...:.|.....|  .
 Worm  2352 ---------------------------RPGRVCVKLVDECREGRHTCSSHADCRDLEEGYTC--E 2387

  Fly  1142 CNSGYILQGPEIKS-----------------CDANGIWE---GPETKCVAINQPRAQSPG----- 1181
            |..||:.:.|.:.|                 |.:..:.|   |.:.:||.|.....||||     
 Worm  2388 CRDGYVDRSPNLASQPGRVCSAPEVCPPNHDCSSAAVCEPLGGMKYQCVCIQGYVDQSPGSQKGR 2452

  Fly  1182 IC--------PALKPAQNGVILPASCTQGPSRFGDVCRLQCNAGFV------------------- 1219
            :|        |.|.......|    |...|..:    |.:|..||:                   
 Worm  2453 VCVRNNACHDPRLNTCSRNAI----CYDEPRGY----RCECKRGFMDRSPDSSQRGRVCEPPPPP 2509

  Fly  1220 -----------------------STGSLLTACMMLQGWSFGADLNCQPFGN-GLLGNQLSPMWNS 1260
                                   :||:....|..|.|:   ||.:..|... |.|.....|:...
 Worm  2510 SPPPRHPCQDPERNDCHPAGTCRATGAQSYTCECLSGY---ADRSPDPRNKPGRLCVLTEPVCLD 2571

  Fly  1261 PKTVTPHQIQNVEQIRPYINCPENVVILLHAG-EQKAHVTLQRPQTNVKNGRLVAHPAWAGQLQG 1324
            |:....|    ...|...:|.||........| ..::...|:||                    |
 Worm  2572 PEQNDCH----AAAICSEVNGPEKYTCKCRDGYTDESPDPLRRP--------------------G 2612

  Fly  1325 HLPAGV--HKVDFRVNDPETKLTIKCHTIITVKAATPRESNPFTL-FRISDYSRSSLPR-PAPFA 1385
            .:..|:  ..:|..:||        ||::...|..    .|.:|. ..|:...:|..|| |....
 Worm  2613 RICKGLINECLDRSLND--------CHSLAVCKDL----PNGYTCQCPINAKDQSPDPRKPGRIC 2665

  Fly  1386 TLSTGSSFSFPAFKALDATPKPVSFTKFQVFPDSESSEHSKLGSSSFFRLEPLF--HESSKLISA 1448
            :||....          |.|...|.:.|....|.|:....:. .:.:...:|..  |..|.:|:.
 Worm  2666 SLSVNEC----------ANPSLNSCSAFADCFDEENGYRCRC-RNGYHDDDPAHPGHRCSFMINE 2719

  Fly  1449 APASSENTRVDLGSDTSNYCPPSIEVYLKENQNLRSVVWDE--PRFEGKLLKIYKSHFPGSLFKV 1511
            ..:|:.|     ..|.:..|..:...|   :...::...||  |:..|::.::.:...|..    
 Worm  2720 CDSSNLN-----DCDRNANCIDTAGGY---DCACKAPYRDEGPPQSPGRICRLNECLNPNR---- 2772

  Fly  1512 GDHAIKYEATTTD---GKTLSCTFFIYVRSAKPTPAPTEPK---ISFDSEPETLSDVSQTYVVCP 1570
              :.....|...|   |.|.:|....|.:|    |.|.||.   |.|..| |.:..|..|.|   
 Worm  2773 --NTCDRNADCRDLDYGYTCTCRHGFYDQS----PNPQEPGRICIEFQQE-EHIERVKVTTV--- 2827

  Fly  1571 DKEPVR 1576
            ..||.|
 Worm  2828 QSEPRR 2833

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342 11/35 (31%)
cEGF 396..415 CDD:289433 5/19 (26%)
FXa_inhibition 425..458 CDD:291342 9/52 (17%)
FXa_inhibition 476..505 CDD:291342 11/28 (39%)
vWFA <550..586 CDD:294047 13/49 (27%)
FXa_inhibition 596..630 CDD:291342 13/52 (25%)
FXa_inhibition 636..>664 CDD:291342 7/29 (24%)
EGF_CA 676..715 CDD:284955 11/38 (29%)
FXa_inhibition 745..780 CDD:291342 10/42 (24%)
FXa_inhibition 786..821 CDD:291342 10/39 (26%)
FXa_inhibition 827..862 CDD:291342 9/42 (21%)
FXa_inhibition 874..904 CDD:291342 10/35 (29%)
FXa_inhibition 945..980 CDD:291342 11/56 (20%)
CCP 1110..1170 CDD:153056 14/80 (18%)
CCP 1183..1235 CDD:153056 15/101 (15%)
DUF5011 1468..1536 CDD:295940 12/72 (17%)
mua-3NP_001022674.1 LDLa 32..60 CDD:238060
LDLa 131..164 CDD:238060
EGF_3 766..795 CDD:289699
vWA_collagen_alphaI-XII-like 1229..1398 CDD:238759 37/188 (20%)
EGF_3 1662..1691 CDD:289699 6/28 (21%)
EGF_CA 1709..1755 CDD:214542 17/53 (32%)
EGF_CA 1964..1997 CDD:214542 12/48 (25%)
SEA 2873..2998 CDD:214554
SEA 3049..3173 CDD:214554
EGF_CA 3328..3364 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4721at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100900
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1431
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

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