DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and fbn-1

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_001263709.1 Gene:fbn-1 / 176076 WormBaseID:WBGene00022816 Length:2781 Species:Caenorhabditis elegans


Alignment Length:1852 Identity:386/1852 - (20%)
Similarity:586/1852 - (31%) Gaps:678/1852 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   123 DEKVGYDLEDYSDETVPNDYVENSDIDEDDDEEVS--EREPPPPPPPP----------VVDGADS 175
            ||::.....|.|..|..    ...::|..|:.|.|  :.:|..|.|.|          :...:::
 Worm  1186 DEEITATTRDVSKSTKK----PRVEVDGGDNGETSGVDGKPTTPAPTPSSSAESSTSRIPTTSEA 1246

  Fly   176 KPE----------------------PQIVIEINDDHANEVVESEPALAETETENEVLENETPLKA 218
            .||                      |..|...:...|.||    |..:.:.|.:.|.|:..|..:
 Worm  1247 SPEGGSGEAGVPESPDGSGESSTSAPDGVSPTSSATAPEV----PTTSASSTPDAVEESGIPSTS 1307

  Fly   219 EVQTDVLNSSNASVKVTN--------DPYEPTFLDNNCGEDNGGCAHICK-RLLYPDENQPINKC 274
            :...:.|.::..|.:||:        ....||   ...||.....|...: ..:.|.:|:.....
 Worm  1308 KPTAEPLETTAPSTEVTSPEGSGTEESTLPPT---EGSGESTTSSAPTVEPATVLPPQNRNEKPE 1369

  Fly   275 DCREGYTL--------DPNDYA----SCLDIDECLESNGGCSEICENLPGEYKCSCQEGYYLDES 327
            ..::.:.|        ..||.:    .|...|||     |...:||...|  .|.|:.|:.....
 Worm  1370 PTKDTFALPTTTTGAPQANDSSVENTKCTSSDEC-----GLDALCERRTG--VCRCEPGFEGAPP 1427

  Fly   328 GKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSESQP 392
            .|||||::|||..:.:.:....|:|..|.|.|.                                
 Worm  1428 KKSCVDVDECATGDHNCHESARCQNYVGGYACF-------------------------------- 1460

  Fly   393 AGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVC---QQKCENTIGSFRCTCVEGYHLLED 454
                |.:||:.:.||: ||||:||       .::|:.|   ..||.|..|::.|.|..|:  |.|
 Worm  1461 ----CPTGFRKADDGS-CQDIDEC-------TEHNSTCCGANAKCVNKPGTYSCECENGF--LGD 1511

  Fly   455 QRSCALDSCTDLENPQLNRTRCAH---ECQ-DLPEGSYRC-VCPKGYELS----EDQHSCLVQES 510
            ...|...:....::.|.:::.|:.   .|: |..:||..| .|..||:.|    ||.:.|:.:::
 Worm  1512 GYQCVPTTKKPCDSTQSSKSHCSESNMSCEVDTVDGSVECKECMGGYKKSGKVCEDINECVAEKA 1576

  Fly   511 PCSTEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLC-SHT-CQNTPGG 573
            |||..        ..|:  ..|.:|||.|..|||.:.|.|.||:|| ::.|.| .|. |.|..|.
 Worm  1577 PCSLN--------ANCV--NMNGTFSCSCKQGYRGDGFMCTDINEC-DERHPCHPHAECTNLEGS 1630

  Fly   574 YQCQCPEGL--NLVEEYTCLAENLCEVNNNGCEQI----CLTAR------GGVCACREGFRLSAD 626
            ::|:|..|.  :.:::.|...|..||.....|.::    ||:.|      ..||.|..|||...:
 Worm  1631 FKCECHSGFEGDGIKKCTNPLERSCEDVEKFCGRVDHVSCLSVRIYNGSLSSVCECEPGFRFEKE 1695

  Fly   627 GKSCEDVDECLVNNGGC---QQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCS 688
            ..||.|:|||..:...|   ..||.|..|||.|.||.|||     |..|.|.|||||.:...||.
 Worm  1696 SNSCVDIDECEESRNNCDPASAVCVNTEGSYRCECAEGYE-----GEGGVCTDIDECDRGMAGCD 1755

  Fly   689 DQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNCS 753
            ...:|.|..||..|.|..||                        |....||:.|:|         
 Worm  1756 SMAMCINRMGSCGCKCMAGY------------------------TGDGATCIKIEE--------- 1787

  Fly   754 HFCQNEPGGFQCACPLGYALSEDMRTCQ------DIDE--------CLDS----NGQCSQLCLNQ 800
                 ||...:.||     ..|..|.|:      .:||        ||..    ||.|..|   |
 Worm  1788 -----EPKSDKTAC-----TDEWSRLCELEKKQCTVDEEEVPQCGACLPGHHPINGTCQSL---Q 1839

  Fly   801 PGGFACACETGFELTPDGFGCADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLSCLDV 865
            ..|.                ||..::|:: :..|.||..:   :|.|:|..|:  ..|.:.|.||
 Worm  1840 ISGL----------------CAQKNDCNK-HAECIDIHPD---SHFCSCPDGF--IGDGMICDDV 1882

  Fly   866 DECAGLLSGGCSHE---CINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPIEC 927
            |||..  :|.|..|   |.|..|:|.|.|..|:                                
 Worm  1883 DECNN--AGMCDDENTKCENTIGSFNCVCLEGF-------------------------------- 1913

  Fly   928 NPGYTLGSDDKCV------------DIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTC 980
                 ...|:|||            :|||....:.........|:|....:.|....|.|.:.| 
 Worm  1914 -----KKVDEKCVVDEKKQPNREKIEIDEENSSSSNSGQEKPTTKGDTNSTTPSTSSLASVKST- 1972

  Fly   981 QDIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEIPTASSLPESPKIELKTPKYP-DFTELS 1044
                ...:::|:..|                 .|....||..:......|....|..| :.|..|
 Worm  1973 ----SAPEERTTVST-----------------TVSTTTPTEETTTSESLILTAAPSKPTESTTES 2016

  Fly  1045 NEIPENPKKPAE---FDYPEP--------KFPSLPKWEGLPKLPPLADIPTSKAPVP-------- 1090
            :|.|..|.|.:|   ...|:|        |..:.....|.|.:.|.|::.|:.||.|        
 Worm  2017 SEAPTTPAKTSETKSLTTPQPPPTTTTTAKPATTSGKRGPPSIQPPAEMFTTPAPPPPSNGGYGE 2081

  Fly  1091 -LRPEVPKSLWVNQLQPRDLCPRFQAPR-------------------NGKSHCNRYRHKQKLFYY 1135
             ...|..:.......:...||.......                   :|.:.|::......:...
 Worm  2082 ETNQEEEQVTSTTTTEAPSLCSTVTCHSLATCEQSTGVCICRDGFIGDGTTACSKKSTADCISLP 2146

  Fly  1136 SRC-----------RISCNSGYILQG------------------PEI----KSCDANGIWEGPET 1167
            |.|           ...|::|||..|                  ||.    :.|.....:.|...
 Worm  2147 SLCADKAKCDNSTRSCECDAGYIGDGYVCSPHPQDCVLRDNLCSPEAVCQNRRCQCLPGFTGDGV 2211

  Fly  1168 KCVAINQPRAQSPGICPALKPAQNGVILPASCTQGPSRFGD----------------------VC 1210
            |||:|:: ||.:...|.|......|    .:|...|..||:                      ||
 Worm  2212 KCVSIHE-RASNCSQCDANAHCVGG----TTCKCNPGYFGNGLCCVPDPLDCVHFTGICHPNAVC 2271

  Fly  1211 -----RLQCNAGFVSTG------------------------------------------------ 1222
                 :.||::||...|                                                
 Worm  2272 NSESRQCQCSSGFSGNGVSCFPQKSCRTDKSVCAKNAICLPTGSCICRHGFKGDPFYKCSSLVSK 2336

  Fly  1223 ------------SLLTAC---------------------MMLQGWSFGADLN------------- 1241
                        |.:|.|                     ..|.|....||::             
 Worm  2337 EPANQQDLSDVSSCVTPCDSSTQLCISGECICKSGFRRNSTLSGSETCADIDECAEKSHKCDRVA 2401

  Fly  1242 -----------------------CQPFGNG--------------LLGNQLSPMWNSPKTVTPHQI 1269
                                   |.|..|.              :|||:.:..  ..|.....|.
 Worm  2402 TCRNTFGSHVCTCPDGHVGDGITCVPHVNQGKLSVYCEADGMTLVLGNETADF--EGKIFVKGQA 2464

  Fly  1270 QNVEQIRPYINCPENVVILLHAGEQKAHV----------------TLQRPQTNVKNGRLVAHPAW 1318
            :|     ||  |.::...||::  :|.:|                |:.......|:...:.:.|.
 Worm  2465 EN-----PY--CSKSFSSLLNS--RKPYVFKVVFQHCDVQLLDNHTMASTVVVQKHAMFLTNKAD 2520

  Fly  1319 AGQLQGHLPAGVHKVDFRVNDPETKLTIKCHTIITVKAATPRESN--PFTLFRISDYSRSSLPRP 1381
            :..|:...|.|...|:..||..|         :.|....|.:.|.  |.....:|:...||:   
 Worm  2521 SYDLRCQYPIGSRAVESHVNVSE---------LATTSTLTEKNSTLAPICRLSVSNDQHSSI--- 2573

  Fly  1382 APFATLSTGSSFSFPAFKALDATPKPVSFTKFQVFP------DSESSEHSKLGSSSFFRL-EPLF 1439
               ::...|.:...    ||:.||.    ..|.:.|      :.||.|...|.......: |.||
 Worm  2574 ---SSAMVGDTLKL----ALEVTPS----ENFGILPRNCFAINIESGERYTLTDDMGCAIDESLF 2627

  Fly  1440 HESSKLISAAPASS-----------ENTRVDLGSDTSNYCPPSI----------EVYLKENQNLR 1483
            .:    .|||.:|.           :::.:....|    |.|.:          ....:.:|...
 Worm  2628 PQ----WSAATSSKVQAVFRTFKWPDSSMIRFQCD----CNPCVGQCSTPTCISSARFRRHQTTS 2684

  Fly  1484 SVVWDEPRFEGKLLKIYKSHFPGSLFKVGD-HAIK-----------YEATTTDGKTLS------- 1529
            .||.||.|.|..|:...:|....|:..|.| |.:.           .:||:.:.|::.       
 Worm  2685 PVVNDEIRQEMVLMSGVESLAVSSIINVHDSHDMNTSDDDDVTSSHVDATSKESKSICVKMAPLL 2749

  Fly  1530 --------CT-FFIYVRSAKPTPAPTEPKISF 1552
                    |: ..:|:.|.||.....|.::.|
 Worm  2750 IALGSFAVCSAILLYLCSKKPKTIDLESELRF 2781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 9/34 (26%)
cEGF 396..415 CDD:463661 9/18 (50%)
FXa_inhibition 425..458 CDD:464251 11/35 (31%)
FXa_inhibition 476..505 CDD:464251 12/37 (32%)
EGF_CA 552..>581 CDD:214542 12/30 (40%)
FXa_inhibition 596..630 CDD:464251 12/43 (28%)
FXa_inhibition 636..>664 CDD:464251 13/30 (43%)
EGF_CA 676..711 CDD:214542 15/34 (44%)
FXa_inhibition 745..780 CDD:464251 6/34 (18%)
FXa_inhibition 786..821 CDD:464251 8/38 (21%)
vWFA <821..861 CDD:469594 11/39 (28%)
FXa_inhibition 874..904 CDD:464251 10/32 (31%)
FXa_inhibition 945..980 CDD:464251 5/34 (15%)
PTZ00449 <1017..>1098 CDD:185628 24/101 (24%)
CCP 1110..1170 CDD:153056 15/111 (14%)
CCP 1183..1235 CDD:153056 19/159 (12%)
HYR 1468..1536 CDD:460572 19/105 (18%)
fbn-1NP_001263709.1 EGF_3 140..170 CDD:463759
EGF_CA 172..210 CDD:214542
EGF_CA 220..253 CDD:429571
EGF_3 309..342 CDD:463759
EGF_CA 344..381 CDD:214542
Herpes_BLLF1 <918..1383 CDD:282904 37/207 (18%)
EGF_CA 1433..1464 CDD:429571 10/66 (15%)
EGF_CA 1475..1516 CDD:214542 15/49 (31%)
EGF_3 1571..1606 CDD:463759 14/44 (32%)
EGF_CA 1608..1642 CDD:238011 13/34 (38%)
EGF_CA 1701..1733 CDD:429571 14/31 (45%)
EGF_CA 1743..1783 CDD:214542 17/63 (27%)
EGF_CA 1881..1912 CDD:429571 14/32 (44%)
EGF_3 2258..2291 CDD:463759 7/32 (22%)
EGF_3 2390..2425 CDD:463759 0/34 (0%)
ZP 2438..2674 CDD:214579 51/277 (18%)
Blue background indicates that the domain is not in the aligned region.

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