DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frac and Ltbp3

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_006531731.1	Gene:	Ltbp3 / 16998	MGIID:	1101355	Length:	1300	Species:	Mus musculus

Alignment Length:	964	Identity:	271/964 - (28%)
Similarity:	361/964 - (37%)	Gaps:	282/964 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 PPPPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPALAE---------TETEN------EVL 210
            |..||.|..:..:.|:..|     :.|......|..:|.::|         |.|.:      |::
Mouse   481 PDGPPKPQQLPESPSRAPP-----LEDTEEERGVTMDPPVSEERSVQQSHPTTTTSPPRPYPELI 540

  Fly   211 ENETPLKAEVQTDVLNSSNASVKVTNDPYEPTFLD------NNCGEDNGGCAHICKRLLYPDENQ 269
            ...:|.........|..|.::|::.  |.:.|..|      |.||  :|.|.        |..:.
Mouse   541 SRPSPPTFHRFLPDLPPSRSAVEIA--PTQVTETDECRLNQNICG--HGQCV--------PGPSD 593

  Fly   270 PINKCDCREGYTLDPNDYASCLDIDEC-LESNGGCSEICENLPGEYKCSCQEGY--YLDESGKSC 331
              ..|.|..||...| .:..|:|::|| .|..|....||.|..|.|.|.|..||  ::...|:||
Mouse   594 --YSCHCNAGYRSHP-QHRYCVDVNECEAEPCGPGKGICMNTGGSYNCHCNRGYRLHVGAGGRSC 655

  Fly   332 VDINECANPELSSNCQGACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSESQPAGKT 396
            ||:|||..|.|..: .|.|.|.||.|:|                                    .
Mouse   656 VDLNECTKPHLCGD-GGFCINFPGHYKC------------------------------------N 683

  Fly   397 CNSGFQLSADGTD-CQDINECEVDGPEDLDNNAVCQQKCENTIGSFRC-TCVEGYHLLEDQRSCA 459
            |..|::|.|.... |:||:||.       |.:.....||||..|||:| .|..||      ||..
Mouse   684 CYPGYRLKASRPPICEDIDECR-------DPSTCPDGKCENKPGSFKCIACQPGY------RSQG 735

  Fly   460 LDSCTDLENPQLNRTRCAHE-CQDLPEGSYRCVCPKGYELSEDQHSCL-VQESPCSTEKGVEKCS 522
            ..:|.|: |.....|.|:.. |::|| |||||.|.:|||.::|..||: |.|  |...|   .|.
Mouse   736 GGACRDV-NECSEGTPCSPGWCENLP-GSYRCTCAQGYEPAQDGLSCIDVDE--CEAGK---VCQ 793

  Fly   523 PGTCLASEDNT--SFSCICPTGYR--SEAFSCQDIDECAEDTHLCSHTCQNTPGGYQCQCPEGLN 583
            .|.|    .||  ||.|.|.:||.  .:...|:|||||..........|.||.|.|:|.||:|..
Mouse   794 DGIC----TNTPGSFQCQCLSGYHLSRDRSRCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHR 854

  Fly   584 LVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRLSADGKSCEDVDECLVNNGGC--QQV 646
            ||                                        .|:.|:|:|||..:.|.|  ...
Mouse   855 LV----------------------------------------GGRKCQDIDECSQDPGLCLPHGA 879

  Fly   647 CRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGC----------------SDQMLCEN 695
            |.||.|||.|:|..|:.|                :|..|||                .|.:.|::
Mouse   880 CENLQGSYVCVCDEGFTL----------------TQDQHGCEEVEQPHHKKECYLNFDDTVFCDS 928

  Fly   696 LNGS---------------------YTC----------LCPPGYALGLDNHIVTSLNSSFITDST 729
            :..:                     |.|          |||.|.....||:||   |...
Mouse   929 VLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIV---NYGI----- 985

  Fly   730 SSETPSAHTCLDIDECSLANGN-CSH-FCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQ 792
                 .||.  |||||.|.... |.. .|.|...|::|.|..|:....::..|.|:|||||.:..
Mouse   986 -----PAHR--DIDECILFGAEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNC 1043

  Fly   793 CSQLCLNQPGGFACACETGFELTPDGFGC-----ADIDECSQDYGNC-SDICINLLGTHACACER 851
            .:.:|.|..||:.|||....|.:|....|     .|:||| ||...| ...|:||.|::.|.|..
Mouse  1044 RNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDEC-QDPAACRPGRCVNLPGSYRCECHP 1107

  Fly   852 GYELAKDKLSCLDVDE------------CAGLL--SGGCSHECINKAGTF-ECGCPLGYILNDDG 901
            .:|.......| .:.|            |.|..  .|.|.......|.|| :|.|..|   ...|
Mouse  1108 PWEPGPSGRDC-QLPESQAEHAPERREVCWGQRGEDGMCMGPLAGPALTFDDCCCRQG---RGWG 1168

  Fly   902 RSCSPALVGCPPGTQRSADGCAPIECNPGY-----TLG-----SDDKCVDIDECQKQNGGCSHRC 956
            ..|.|    |||....|....:..|.|..:     .||     .|....|.|||:..:|    ||
Mouse  1169 TQCRP----CPPRGTGSQCPTSQSESNSFWDTSPLLLGKSPRDEDSSEEDSDECRCVSG----RC 1225

  Fly   957 SNTEGSFKCSCPPGYELDSDQKTCQDIDEC---DQDKTSCITGTCINEIGGFRC 1007
            ....|...|.||.|::||:.:..|.|||||   :|....|.:..|:|..|.|||
Mouse  1226 VPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRC 1279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	13/37 (35%)
		cEGF	396..415	CDD:289433	7/19 (37%)
		FXa_inhibition	425..458	CDD:291342	13/33 (39%)
		FXa_inhibition	476..505	CDD:291342	14/29 (48%)
		vWFA	<550..586	CDD:294047	16/35 (46%)
		FXa_inhibition	596..630	CDD:291342	1/33 (3%)
		FXa_inhibition	636..>664	CDD:291342	12/29 (41%)
		EGF_CA	676..715	CDD:284955	13/85 (15%)
		FXa_inhibition	745..780	CDD:291342	9/36 (25%)
		FXa_inhibition	786..821	CDD:291342	12/34 (35%)
		FXa_inhibition	827..862	CDD:291342	11/35 (31%)
		FXa_inhibition	874..904	CDD:291342	9/30 (30%)
		FXa_inhibition	945..980	CDD:291342	11/34 (32%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Ltbp3	XP_006531731.1	EGF_CA	352..387	CDD:214542
		TB	411..453	CDD:366245
		EGF_CA	613..656	CDD:214542	16/42 (38%)
		EGF_CA	657..691	CDD:238011	15/70 (21%)
		EGF_CA	700..733	CDD:214542	16/45 (36%)
		EGF_CA	741..781	CDD:214542	18/41 (44%)
		EGF_CA	782..822	CDD:214542	15/48 (31%)
		EGF_CA	823..862	CDD:214542	17/78 (22%)
		EGF_CA	863..896	CDD:214542	15/32 (47%)
		TB	926..969	CDD:366245	4/42 (10%)
		EGF_CA	1033..>1061	CDD:214542	13/27 (48%)
		EGF_CA	1079..1114	CDD:214542	14/35 (40%)
		TB	1144..>1179	CDD:366245	13/41 (32%)
		EGF_CA	1251..1289	CDD:214542	13/29 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42398
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020