Protein Alignment frac and Ldlr

DIOPT Version :10

• Sequence 1: NP_648137.3
• Gene: frac / 38850
• FlyBaseID: FBgn0035798
• Length: 1618
• Species: Drosophila melanogaster
• Sequence 2: NP_034830.2
• Gene: Ldlr / 16835
• MGIID: 96765
• Length: 862
• Species: Mus musculus
• Alignment Length: 272
• Identity: 61/272 - (22%)
• Similarity: 92/272 - (33%)
• Gaps: 81/272 - (29%)

  Fly   169 RFVDTSRGRSPPRNAGSFIGIPREPSPPRNGRRMIGSARDRSPPRN--------AGRRFGPPRDQ 225
            |||  .|.||.|:    .:.:|...:||           ..|.|::        :|..||...|.
Mouse   253 RFV--KRKRSLPK----ALMLPENNTPP-----------FWSDPKDNISKVEMWSGMFFGMKPDP 300

  Fly   226 SPPRNAGRVTGSPRDRSPPRNAGRRMGPPRDQ--SPPRSTRSFSSNSRALSPARNMGSYMSSSQG 288
            ..|    .:|....:.:...||.....|.|.|  .|.:::|..|.|.....||:......:||..
Mouse   301 QTP----SLTPQKSEITVKDNAYASQEPYRCQQDGPIQNSREPSENYSLCLPAQMPKESFNSSDS 361

  Fly   289 FSP-PRNPRSYMGSSRGSPPRSNIEDFHGRSRMLDNMRASPYPVRGVLNGQAPSSGAPFARPMLP 352
            ||| ..:|:  |..|..|...:|.:.|..:|   |:::        ::...|..|
Mouse   362 FSPESESPK--MIHSDTSESLNNSDTFTPKS---DSVK--------LIQSDANES---------- 403

  Fly   353 PPVPNPHPLPPLSQLPPLGSIMQNSPFSVDEPLSVDGFLNSIGLGKYSLAFKREEVDMTTIKQMK 417
              ..|...|...|.|..|..:..|..||     |.|.|                 :.:|...:..
Mouse   404 --FNNSESLSSDSDLVELIHLDTNESFS-----SSDSF-----------------IPVTDSVEFI 444

  Fly   418 ESD--LKDLIIP 427
            .||  .|.|::|
Mouse   445 HSDAECKTLVVP 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_648137.3	FXa_inhibition	296..331	CDD:464251	7/34 (21%)
		cEGF	396..415	CDD:463661	1/18 (6%)
		FXa_inhibition	425..458	CDD:464251	1/3 (33%)
		FXa_inhibition	476..505	CDD:464251
		EGF_CA	552..>581	CDD:214542
		FXa_inhibition	596..630	CDD:464251
		FXa_inhibition	636..>664	CDD:464251
		EGF_CA	676..711	CDD:214542
		FXa_inhibition	745..780	CDD:464251
		FXa_inhibition	786..821	CDD:464251
		vWFA	<821..861	CDD:469594
		FXa_inhibition	874..904	CDD:464251
		FXa_inhibition	945..980	CDD:464251
		PTZ00449	<1017..>1098	CDD:185628
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		HYR	1468..1536	CDD:460572
Ldlr	NP_034830.2	Ldl_recept_a	25..58	CDD:395011
		Ldl_recept_a	66..104	CDD:395011
		Ldl_recept_a	107..143	CDD:395011
		Ldl_recept_a	146..184	CDD:395011
		Ldl_recept_a	196..232	CDD:395011
		Ldl_recept_a	236..271	CDD:395011	8/23 (35%)
		Ldl_recept_a	279..309	CDD:395011	7/33 (21%)
		FXa_inhibition	319..>347	CDD:464251	7/27 (26%)
		EGF_CA	355..389	CDD:214542	11/35 (31%)
		LDL-receptor class B 1	398..439		13/74 (18%)
		LY	420..458	CDD:214531	12/59 (20%)
		LDL-receptor class B 2	440..485		5/17 (29%)
		Ldl_recept_b	440..483	CDD:459654	5/17 (29%)
		LDL-receptor class B 3	486..528
		Ldl_recept_b	486..526	CDD:459654
		LDL-receptor class B 4	529..572
		Ldl_recept_b	529..569	CDD:459654
		LY	553..595	CDD:214531
		LDL-receptor class B 5	573..615
		LDL-receptor class B 6	616..658
		Ldl_recept_b	616..656	CDD:459654
		FXa_inhibition	675..712	CDD:464251
		Clustered O-linked oligosaccharides	722..770
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	730..761
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130	813..862
		NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130	825..830