DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and Fbn2

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_034311.2 Gene:Fbn2 / 14119 MGIID:95490 Length:2907 Species:Mus musculus


Alignment Length:1456 Identity:381/1456 - (26%)
Similarity:520/1456 - (35%) Gaps:556/1456 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   241 PTFLD-NNCGEDNGGCAH-ICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLESNGGC 303
            |.:.| |.|....|.|.: .|:..:      ...||.|..|:.||..: .:|.|||||..|...|
Mouse  1062 PFYKDINECKAFPGMCTYGKCRNTI------GSFKCRCNNGFALDMEE-RNCTDIDECRISPDLC 1119

  Fly   304 -SEICENLPGEYKCSCQEGYYLDESG----KSCVDINEC-ANPELSSNCQ-GACENLPGSYRCVE 361
             |.||.|.||.::|.|.|||   |||    |:|:||:|| .||.|   |: |.|.|..||::|..
Mouse  1120 GSGICVNTPGSFECECFEGY---ESGFMMMKNCMDIDECERNPLL---CRGGTCVNTEGSFQCDC 1178

  Fly   362 PL--EENPEITEVVENPIEKTNEVPV--NVSESQPAGK----------TCNSGFQLSADGTDCQD 412
            ||  |.:|...:.|:     .||..:  |:..:   ||          :||.|:|.:.|...|.|
Mouse  1179 PLGHELSPSREDCVD-----INECSLSDNLCRN---GKCVNMIGTYQCSCNPGYQATPDRQGCTD 1235

  Fly   413 INECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCA-LDSCTDLENPQLNRTRC 476
            |:||.:       .|..|..:|.|:.||:.|:|.|||.|:.|.|||| :|.|.:  ||.:    |
Mouse  1236 IDECMI-------MNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECEN--NPDI----C 1287

  Fly   477 -AHECQDLPEGSYRCVCPKGYELSEDQHSCL-VQE----------SPCSTEKG------------ 517
             ..:|.::| |.|||:|..|:..|.|..:|: |.|          ..|...||            
Mouse  1288 DGGQCTNIP-GEYRCLCYDGFMASMDMKTCIDVNECDLNPNICMFGECENTKGSFICHCQLGYSV 1351

  Fly   518 ---------VEKCSPG--------TCLASEDNT--SFSCICPTGYRSEAFSCQDIDECAEDTHLC 563
                     |::|..|        :||    |.  ||.|.|..|:......|.|:||||..||.|
Mouse  1352 KKGTTGCTDVDECEIGAHNCDMHASCL----NVPGSFKCSCREGWVGNGIKCIDLDECANGTHQC 1412

  Fly   564 S--HTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQ-ICLTARGGV-CACREGFRLS 624
            |  ..|.||||.|:|.|.||.. .:.:||...:.|..|.|.||. .||...|.. |.|..||..:
Mouse  1413 SINAQCVNTPGSYRCACSEGFT-GDGFTCSDVDECAENTNLCENGQCLNVPGAYRCECEMGFTPA 1476

  Fly   625 ADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTH---- 685
            :|.:||:|:|||...|......|.||||.:.|||..|||   ||...|.|.|||||:...:    
Mouse  1477 SDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYE---LDRTGGNCTDIDECADPINCVNG 1538

  Fly   686 ------------------------GCSDQ------------------------------------ 690
                                    ||.|.                                    
Mouse  1539 LCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEVGVGVSRSSCCCSL 1603

  Fly   691 ----------------------------------------------------------------- 690
                                                                             
Mouse  1604 GKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQC 1668

  Fly   691 ------------MLCENLN------------------GSYTCLCPPGYALGLDNHIVTSLNSSFI 725
                        .:||:::                  |:|||:|||.|......|....:..||.
Mouse  1669 ECPQGYYLSEETRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFC 1733

  Fly   726 TDS---TSSE------------------------------TPSA-----------------HT-- 738
            ..|   |:.|                              ||..                 ||  
Mouse  1734 YRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGK 1798

  Fly   739 CLDIDECSLANGNCSH-FCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQL--CLNQ 800
            .:|||||....|.|:: .|.|:.|.|:|.||.|::.::.:..|:|||||.:.:..|.:.  |:|.
Mouse  1799 AVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINS 1863

  Fly   801 PGGFACACETGFELTPDGFGCADIDECSQDYGNCS-DICINLLGTHACACERGYELAKDKLSCLD 864
            ||.:.|.|..||:|:|:| .|.|.:||.:....|| .:|::|.|::.|.|..|::.::|:..|:|
Mouse  1864 PGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICNNGFKASQDQTMCMD 1927

  Fly   865 VDECAGLLSGGCSHECINKAGTFECGCPLGYIL---ND--DGRSCSPALVG--CPPGTQRSADGC 922
            ||||.....|  :..|.|..|::.|.|..|:.|   ||  |...|| :..|  |..|...:..|.
Mouse  1928 VDECERHPCG--NGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECS-SFFGQVCRNGRCFNEIGS 1989

  Fly   923 APIECNPGYTLGSDDK-CVDIDECQKQNGGCS-HRCSNTEGSFKCSCPPGYELDSDQKTCQDIDE 985
            ....||.||.|..|.| |:|.:||....|.|| ..|.|.||||:|.||||||:.|:  .|.||:|
Mouse  1990 FKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVRSE--NCIDINE 2052

  Fly   986 CDQDKTSCITGTCINEIGGFRCEFPKFPVLPE-----IPTASSLPESPKIELKTPKYPDFTELSN 1045
            ||:|...|:.|:|.|..|||:|..|...||.:     ..|..|.              .||..  
Mouse  2053 CDEDPNICLFGSCTNTPGGFQCICPPGFVLSDNGRRCFDTRQSF--------------CFTNF-- 2101

  Fly  1046 EIPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPEVPKSLWVNQLQPRDLC 1110
               ||.|            .|:||           ...|:||.. ...::|...|.:   |.:||
Mouse  2102 ---ENGK------------CSVPK-----------AFNTTKAKC-CCSKMPGEGWGD---PCELC 2136

  Fly  1111 PR-----FQ-----------APRNGKSHCNRYRHKQKLFYYSRC-------RISCNSGYILQGPE 1152
            |:     ||           :..:.:...|.......:....:|       |..|..||.|....
Mouse  2137 PKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTG 2201

  Fly  1153 IKSCDAN--------------------------GIWEGPETKCVAINQPRAQSP----------- 1180
            ::..|.:                          |...||...|..||: .||:|           
Mouse  2202 VRCVDTDECSIGNPCGNGTCTNVIGSFECTCNEGFEPGPMMNCEDINE-CAQNPLLCAFRCMNTF 2265

  Fly  1181 ------------------------------------------------GICP---ALKPAQNGVI 1194
                                                            .|||   |.:|...|.:
Mouse  2266 GSYECTCPVGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCV 2330

  Fly  1195 LPASCTQGPSRFGDVC------------RLQCNAGFVSTGS----------------LLTACMML 1231
            ....|...|.    :|            |.:||.||.|:.|                |.|.|.|.
Mouse  2331 DENECRTKPG----ICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTMCQMA 2391

  Fly  1232 -----------------QGWSFGADL 1240
                             :||....:|
Mouse  2392 SSSRNLVTKSECCCDGGRGWGHQCEL 2417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342 18/39 (46%)
cEGF 396..415 CDD:289433 8/18 (44%)
FXa_inhibition 425..458 CDD:291342 14/32 (44%)
FXa_inhibition 476..505 CDD:291342 11/29 (38%)
vWFA <550..586 CDD:294047 20/37 (54%)
FXa_inhibition 596..630 CDD:291342 13/35 (37%)
FXa_inhibition 636..>664 CDD:291342 12/27 (44%)
EGF_CA 676..715 CDD:284955 18/197 (9%)
FXa_inhibition 745..780 CDD:291342 11/35 (31%)
FXa_inhibition 786..821 CDD:291342 13/36 (36%)
FXa_inhibition 827..862 CDD:291342 10/35 (29%)
FXa_inhibition 874..904 CDD:291342 11/34 (32%)
FXa_inhibition 945..980 CDD:291342 18/35 (51%)
CCP 1110..1170 CDD:153056 15/108 (14%)
CCP 1183..1235 CDD:153056 20/99 (20%)
DUF5011 1468..1536 CDD:295940
Fbn2NP_034311.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..58
Interaction with MFAP4. /evidence=ECO:0000250|UniProtKB:P35556 149..359
TB 225..258 CDD:279073
EGF_CA 276..>306 CDD:214542
TB 375..412 CDD:279073
EGF_CA 528..558 CDD:214542
EGF_CA 568..609 CDD:214542
EGF_CA 610..642 CDD:238011
cEGF 631..654 CDD:289433
EGF_CA 651..691 CDD:214542
TB 708..744 CDD:279073
cEGF 783..806 CDD:289433
EGF_CA 803..838 CDD:238011
TB 900..>928 CDD:279073
TB 1005..1040 CDD:279073
EGF_CA 1108..1142 CDD:214542 19/36 (53%)
EGF_CA 1151..1183 CDD:214542 16/34 (47%)
EGF_CA 1193..1225 CDD:214542 8/39 (21%)
cEGF 1216..1238 CDD:289433 8/21 (38%)
FXa_inhibition 1239..1274 CDD:291342 15/41 (37%)
Plasmod_Pvs28 1286..1439 CDD:283826 48/162 (30%)
EGF_3 1364..1399 CDD:289699 10/38 (26%)
EGF_3 1405..1440 CDD:289699 16/35 (46%)
EGF_CA 1484..1519 CDD:214542 18/37 (49%)
EGF_CA 1525..1556 CDD:214542 5/30 (17%)
TB 1586..1621 CDD:279073 0/34 (0%)
EGF_CA 1643..1675 CDD:214542 0/31 (0%)
cEGF 1665..1688 CDD:289433 2/22 (9%)
Interaction with MFAP4. /evidence=ECO:0000250|UniProtKB:P35556 1728..2164 145/487 (30%)
TB 1742..1779 CDD:279073 3/36 (8%)
EGF_CA 1801..1833 CDD:214542 15/31 (48%)
vWFA <1840..1881 CDD:294047 17/40 (43%)
vWFA <1880..1922 CDD:294047 13/42 (31%)
EGF_CA 1927..1961 CDD:214542 13/35 (37%)
EGF_CA 1966..2008 CDD:214542 14/42 (33%)
EGF_CA 2049..2089 CDD:214542 17/39 (44%)
TB 2106..2143 CDD:279073 12/51 (24%)
EGF_CA 2164..2205 CDD:214542 7/40 (18%)
EGF_CA 2206..2245 CDD:214542 4/38 (11%)
vWFA <2244..2283 CDD:294047 6/39 (15%)
TB 2390..2425 CDD:279073 4/28 (14%)
vWFA <2482..2522 CDD:294047
vWFA <2520..2556 CDD:294047
EGF_CA 2607..>2636 CDD:214542
Cadherin_repeat <2821..>2868 CDD:206637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BA2W
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4721at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42398
orthoMCL 1 0.900 - - OOG6_100900
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1431
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.720

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