DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and Fbn1

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:NP_032019.2 Gene:Fbn1 / 14118 MGIID:95489 Length:2873 Species:Mus musculus


Alignment Length:1306 Identity:370/1306 - (28%)
Similarity:483/1306 - (36%) Gaps:418/1306 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   213 ETPLKAEVQTDVL---NSSNASVKVTNDPYEPTFLD-NNCGEDNGGCAH-ICKRLLYPDENQPIN 272
            |.||:...:.:.|   ....|:..:||.  :|.|.| |.|......|.| .|:..:      ...
Mouse   997 ECPLRNSREYEELCPRGPGFATKDITNG--KPFFKDINECKMIPSLCTHGKCRNTI------GSF 1053

  Fly   273 KCDCREGYTLDPNDYASCLDIDECLESNGGCSE-ICENLPGEYKCSCQEGYYLDESG----KSCV 332
            ||.|..|:.|| ::..:|.|||||..|...|.. .|.|.||:::|.|.|||   |||    |:|:
Mouse  1054 KCRCDSGFALD-SEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGY---ESGFMMMKNCM 1114

  Fly   333 DINECANPELSSNCQGA-CENLPGSYRCVEP--LEENPEITEVVE-NPIE-KTNEVP----VNVS 388
            ||:||....|.  |:|. |.|..|||||..|  .:.:|.|:..:: |..| ..|..|    ||: 
Mouse  1115 DIDECQRDPLL--CRGGICHNTEGSYRCECPPGHQLSPNISACIDINECELSANLCPHGRCVNL- 1176

  Fly   389 ESQPAGK---TCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYH 450
                .||   .||.|:..:.|...|.||:||.:       .|..|:..|.|:.||:.|:|..|:.
Mouse  1177 ----IGKYQCACNPGYHPTHDRLFCVDIDECSI-------MNGGCETFCTNSDGSYECSCQPGFA 1230

  Fly   451 LLEDQRSCA-LDSCTDLENPQLNRTRC-AHECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCS 513
            |:.|||||. :|.|.|  ||.:    | ..:|.::| |.|||:|..|:..|||..:| |..:.|.
Mouse  1231 LMPDQRSCTDIDECED--NPNI----CDGGQCTNIP-GEYRCLCYDGFMASEDMKTC-VDVNECD 1287

  Fly   514 TEKGVEKCSPGTCLASEDNT--------------------------------------------- 533
            ....:  |..|||    :||                                             
Mouse  1288 LNPNI--CLSGTC----ENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGRHAVCTNTAG 1346

  Fly   534 SFSCICPTGYRSEAFSCQDIDECAEDTHLCSH--TCQNTPGGYQCQCPEGLNLVEEYTCLAENLC 596
            ||.|.|..|:..:...|.|:|||:..||:||.  .|:||.|.|:|.|.:|.. .:.:||...:.|
Mouse  1347 SFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKDGYT-GDGFTCTDLDEC 1410

  Fly   597 EVNNNGC-EQICLTARGGV-CACREGFRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICA 659
            ..|.|.| ...||.|.||. |.|..||..|||||:|||:|||.:.|......|.||||.:.|.|.
Mouse  1411 SENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECE 1475

  Fly   660 AGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPP------------------ 706
            .|||   ||...|.|.|::||...|...|..  |.|..|||||.|||                  
Mouse  1476 IGYE---LDRSGGNCTDVNECLDPTTCISGN--CVNTPGSYTCDCPPDFELNPTRVGCVDTRSGN 1535

  Fly   707 ---------------------------------GYALGLDNHIVTSLNSS---FITDSTSSETPS 735
                                             |.|.|....:..|:|:|   .:........|:
Mouse  1536 CYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCELCPSVNTSEYKILCPGGEGFRPN 1600

  Fly   736 AHTCL--DIDECSLANGNC-SHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQ-L 796
            ..|.:  |||||....|.| ...|.|..|.|||.||.||.|:||.|.|.|::|| ::.|.|.. .
Mouse  1601 PITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNEC-ETPGICGPGT 1664

  Fly   797 CLNQPGGFACACETGFELTPDGFGC---------------------------------------- 821
            |.|..|.:.|.|...:.....|..|                                        
Mouse  1665 CYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGR 1729

  Fly   822 -------------------------------------ADIDECSQDYGNCSD-ICINLLGTHACA 848
                                                 .|||||.:..|.|.: :|||::|:..|.
Mouse  1730 AWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCE 1794

  Fly   849 CERGYELAKDKLSCLDVDECAGLLSGG--CSH--ECINKAGTFECGCPLGYILNDDGRS------ 903
            |..|:......|.|.|:|||    ..|  |..  ||||.||::.|.|..||.|...|:.      
Mouse  1795 CPVGFFYNDKLLVCEDIDEC----QNGPVCQRNAECINTAGSYRCDCKPGYRLTSTGQCNDRNEC 1855

  Fly   904 ------CSPA----LVG-----------------------------CPPGTQRSADGCAPIECNP 929
                  ||..    .||                             |..||.|:..|.....||.
Mouse  1856 QEIPNICSHGQCIDTVGSFYCLCHTGFKTNVDQTMCLDINECERDACGNGTCRNTIGSFNCRCNH 1920

  Fly   930 GYTLGSDDKCVDIDECQKQNGG-CSH-RCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTS 992
            |:.|..::.|:|:|||...||. |.: :|.||.|||:|.|..|||:..|.:||.||:||..|...
Mouse  1921 GFILSHNNDCIDVDECATGNGNLCRNGQCVNTVGSFQCRCNEGYEVAPDGRTCVDINECVLDPGK 1985

  Fly   993 CITGTCINEIGGFRCEFPKFPVLPEIPTASSLPESPKIELKTPKYPDFTELSNEIPE-------- 1049
            |..|||.|..|.:||..|                 |...|:..|..|..|...| ||        
Mouse  1986 CAPGTCQNLDGSYRCICP-----------------PGYSLQNDKCEDIDECVEE-PEICALGTCS 2032

  Fly  1050 NPKKPAEFDYPEPKFPSL----------------PKWEGLPKLPPLADIPTSK------------ 1086
            |.:  ..|....|:..||                .|:||     .....|.|:            
Mouse  2033 NTE--GSFKCLCPEGFSLSSTGRRCQDLRMSYCYAKFEG-----GKCSSPKSRNHSKQECCCALK 2090

  Fly  1087 -----APVPLRPEVPKSLWVNQLQPRDLCP----RFQAPRNG---KSHCNR---YRHKQKLFYYS 1136
                 .|..|.|..|...:      |.:||    ....|.:.   ...|..   .||.|.:....
Mouse  2091 GEGWGDPCELCPTEPDEAF------RQICPFGSGIIVGPDDSAVDMDECKEPDVCRHGQCINTDG 2149

  Fly  1137 RCRISCNSGYILQGPEIKSCD------------------------ANGIWEGPETKCVAINQPRA 1177
            ..|..|..||||:|.|....|                        ..|...||...|..||: .|
Mouse  2150 SYRCECPFGYILEGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINE-CA 2213

  Fly  1178 QSPGIC 1183
            |:|.:|
Mouse  2214 QNPLLC 2219

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342 16/39 (41%)
cEGF 396..415 CDD:289433 7/18 (39%)
FXa_inhibition 425..458 CDD:291342 13/32 (41%)
FXa_inhibition 476..505 CDD:291342 12/29 (41%)
vWFA <550..586 CDD:294047 17/37 (46%)
FXa_inhibition 596..630 CDD:291342 18/35 (51%)
FXa_inhibition 636..>664 CDD:291342 11/27 (41%)
EGF_CA 676..715 CDD:284955 18/89 (20%)
FXa_inhibition 745..780 CDD:291342 17/35 (49%)
FXa_inhibition 786..821 CDD:291342 9/35 (26%)
FXa_inhibition 827..862 CDD:291342 11/35 (31%)
FXa_inhibition 874..904 CDD:291342 14/45 (31%)
FXa_inhibition 945..980 CDD:291342 16/36 (44%)
CCP 1110..1170 CDD:153056 19/93 (20%)
CCP 1183..1235 CDD:153056 1/1 (100%)
DUF5011 1468..1536 CDD:295940
Fbn1NP_032019.2 TB 1707..1751 CDD:366245 0/43 (0%)
EGF_CA 1768..>1799 CDD:214542 13/30 (43%)
EGF_CA 1810..1842 CDD:214542 15/35 (43%)
EGF_CA 1932..1973 CDD:311536 19/40 (48%)
EGF_CA 1975..2010 CDD:238011 16/51 (31%)
EGF_CA 2015..2055 CDD:389777 10/42 (24%)
TB 2072..2114 CDD:366245 7/47 (15%)
EGF_CA 2129..2167 CDD:214542 12/37 (32%)
EGF_CA 2168..2207 CDD:214542 4/38 (11%)
TB 2358..2393 CDD:366245
vWFA <2444..2484 CDD:381780
cEGF 2467..2490 CDD:372248
EGF_CA 2487..>2518 CDD:389777
EGF_CA 2526..2568 CDD:214542
EGF_CA 2569..>2598 CDD:214542
EGF_CA 2609..2640 CDD:214542
Fibrillin_U_N 48..82 CDD:375622
TB 194..>228 CDD:366245
EGF_CA 246..>276 CDD:214542
EGF_CA 288..329 CDD:214542
TB 344..389 CDD:366245
EGF_CA 492..523 CDD:214542
EGF_CA 532..573 CDD:214542
EGF_CA 574..614 CDD:214542
EGF_CA 615..648 CDD:214542
TB 671..713 CDD:366245
EGF_CA 725..765 CDD:389777
EGF_CA 767..>798 CDD:214542
cEGF 789..812 CDD:372248
TB 863..>892 CDD:366245
TB 968..1011 CDD:366245 4/13 (31%)
EGF_CA 1072..1106 CDD:214542 17/36 (47%)
EGF_CA 1115..1151 CDD:214542 15/37 (41%)
EGF_CA 1157..1192 CDD:238011 11/39 (28%)
FXa_inhibition 1203..1238 CDD:373209 14/41 (34%)
EGF_3 1328..1363 CDD:372403 5/34 (15%)
EGF_3 1369..1404 CDD:372403 13/35 (37%)
cEGF 1428..1451 CDD:372248 13/22 (59%)
EGF_CA 1448..1488 CDD:214542 18/42 (43%)
EGF_CA 1489..1520 CDD:214542 15/32 (47%)
TB 1551..1592 CDD:366245 6/40 (15%)
EGF_CA 1608..1640 CDD:214542 16/31 (52%)
EGF_CA 1650..1689 CDD:214542 11/39 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BA2W
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42398
orthoMCL 1 0.900 - - OOG6_100900
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1431
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.710

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