DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and Fbln2

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_032018.2	Gene:	Fbln2 / 14115	MGIID:	95488	Length:	1221	Species:	Mus musculus

Alignment Length:	977	Identity:	273/977 - (27%)
Similarity:	375/977 - (38%)	Gaps:	240/977 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 DIDEDDDEEVSE---REPPPPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPAL---AETET 205
            |.:||::||..|   .|||....|..:|...::...:....:.:..|......|..|   |:...
Mouse   270 DTEEDEEEEEEETLVTEPPTAGSPGRLDSLPTRSPARPGFPVQEKEAEAKAGPEENLIPDAQVTP 334

  Fly   206 ENEVLENETPLKAEVQTDVLNSSNASVKVTNDPYEPTFLDNNCGEDNGGCAHICKRLLYPDENQ- 269
            .:.:.|...||... ....|:.|.|:...:.||.:|:             .|.....|.||..|
Mouse   335 RSVMQEGAAPLPRS-GLAALSPSLATDSSSEDPVKPS-------------DHPTLSTLPPDRAQV 385

  Fly   270 -------------PINKCDCREGYTLDPNDYAS------------------------CLDIDECL 297
                         |......|....:|||...|                        .:|.|||.
Mouse   386 SPSPETPEEIPQHPQLLPRFRAEEDIDPNSVHSVPRGDLDGSTKDLIETCCAAGQQWAIDNDECQ 450

  Fly   298 E--SNGGCSEICENLPGEYKC--------SCQEGYYLDESGKSC-VDINECANPELSSNC----- 346
            |  .||..|:||.  ..:.:|        ||..|....:.|::| .:.|:.....|...|
Mouse   451 EIPENGAQSDICR--IAQRQCCISYLKEKSCVAGVMGAKEGETCGAEDNDTCGVSLYKQCCDCCG 513

  Fly   347 -------QG-ACENLPG-SYRCVEPL-----EENPEITEVVENPIEKTNEVPVNVSESQPAGKTC 397
                   :| :||:.|. .|.|...:     .|.|.|...|..|.| ....|..|||.:.|.:..
Mouse   514 LGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPE-PEAAPRRVSEMEMASREA 577

  Fly   398 NSGFQLSADGTDCQ--------DINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLED 454
                 ||. ||:.:        |.:||.:...|      :||..|.||:||:||.|..|:.|..|
Mouse   578 -----LSL-GTEAELPNSLPGDDQDECLMLPGE------LCQHLCINTVGSYRCACFPGFELQGD 630

  Fly   455 QRSCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVE 519
            .|:|.    .|...|||:..|     :..|......|.|....|...|.:......||..
Mouse   631 GRTCR----PDRGAPQLDTAR-----ESAPRSESAQVSPNTIPLPVPQPNTCKDNGPCRQ----- 681

  Fly   520 KCSPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCS--HTCQNTPGGYQC-----Q 577
                 .|....|....||.......::..||:|.|||...||.||  ..|.||.|.:.|     .
Mouse   682 -----VCRVVGDTAMCSCFPGYAIMADGVSCEDQDECLMGTHDCSWKQFCVNTLGSFYCVNHTVL 741

  Fly   578 CPEGLNLVEEYTCLAENLCEVNNNGCEQI--CLTARGG-----VCACREGFRLSADGKSCEDVDE 635
            |.||..|.....|:..|.|..:.:.|.:.  |:...|.     ...|..|:.|: ||: |.||||
Mouse   742 CAEGYILNAHRKCVDINECVTDLHTCTRAEHCVNTPGSFQCYKALTCEPGYVLT-DGE-CTDVDE 804

  Fly   636 CLVNNGGCQQ--VCRNLPGSYGC----ICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCE 694
            |:.....||.  .|:|..||:.|    .|..|:    |....|.|.||:||:.....|.....|.
Mouse   805 CVTGTHNCQAGFSCQNTKGSFYCQARQRCMDGF----LQDPEGNCVDINECTSLLEPCRSGFSCI 865

  Fly   695 NLNGSYTC-----LCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNC-- 752
            |..|||||     :|..||      |          .:...||      |:|::||......|
Mouse   866 NTVGSYTCQRNPLVCGRGY------H----------ANEEGSE------CVDVNECETGVHRCGE 908

  Fly   753 SHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQ-CSQLCLNQPGGFACACETGFELTP 816
            ...|.|.||.::|.|..|:......|||.|::||..|.|: |...|.|.||.:.|:|..||.|..
Mouse   909 GQLCYNLPGSYRCDCKPGFQRDAFGRTCIDVNECWVSPGRLCQHTCENTPGSYRCSCAAGFLLAA 973

  Fly   817 DGFGCADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLSCLDVDEC---AGLLSGGCSH 878
            ||..|.|::||  :...||..|.|:.|::.|.|.:||:||:|..:|.|:|||   ||:|   |:.
Mouse   974 DGKHCEDVNEC--ETRRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGIL---CTF 1033

  Fly   879 ECINKAGTFECGCP-LGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDI 942
            .|:|..|:::|.|| .||.:..:||||.                                   |:
Mouse  1034 RCVNVPGSYQCACPEQGYTMMANGRSCK-----------------------------------DL 1063

  Fly   943 DECQKQNGGCS--HRCSNTEGSFKC---SCPPGY----ELDSDQKTCQDIDECDQDKTSCITGTC 998
            |||......||  ..|.|.:|||:|   .|||.|    |...::.|||||.|| |...:.||...
Mouse  1064 DECALGTHNCSEAETCHNIQGSFRCLRFDCPPNYVRVSETKCERTTCQDITEC-QTSPARITHYQ 1127

  Fly   999 IN 1000
            :|
Mouse  1128 LN 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	12/44 (27%)
		cEGF	396..415	CDD:289433	5/26 (19%)
		FXa_inhibition	425..458	CDD:291342	14/32 (44%)
		FXa_inhibition	476..505	CDD:291342	5/28 (18%)
		vWFA	<550..586	CDD:294047	18/42 (43%)
		FXa_inhibition	596..630	CDD:291342	9/40 (23%)
		FXa_inhibition	636..>664	CDD:291342	10/33 (30%)
		EGF_CA	676..715	CDD:284955	15/43 (35%)
		FXa_inhibition	745..780	CDD:291342	10/36 (28%)
		FXa_inhibition	786..821	CDD:291342	15/35 (43%)
		FXa_inhibition	827..862	CDD:291342	13/34 (38%)
		FXa_inhibition	874..904	CDD:291342	11/30 (37%)
		FXa_inhibition	945..980	CDD:291342	14/43 (33%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Fbln2	NP_032018.2	N	27..434		35/177 (20%)
		Subdomain NA (Cys-rich)	27..176
		Subdomain NB (Cys-free)	177..434		35/177 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..329		14/58 (24%)
		PHA03247	<287..422	CDD:223021	28/148 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..399		13/71 (18%)
		ANATO	420..479	CDD:237984	11/60 (18%)
		Cell attachment site. /evidence=ECO:0000255	421..423		0/1 (0%)
		ANATO	505..553	CDD:237984	10/47 (21%)
		FXa_inhibition	606..634	CDD:373209	14/27 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..661		8/36 (22%)
		vWFA	<707..749	CDD:381780	17/41 (41%)
		EGF_CA	756..>792	CDD:389777	6/35 (17%)
		EGF_CA	801..845	CDD:311536	16/47 (34%)
		EGF_CA	847..893	CDD:311536	18/67 (27%)
		EGF_CA	895..937	CDD:214542	13/41 (32%)
		FXa_inhibition	942..978	CDD:373209	15/35 (43%)
		cEGF	999..1022	CDD:372248	9/22 (41%)
		EGF_CA	1019..1061	CDD:214542	19/44 (43%)
		EGF_CA	1062..1110	CDD:311536	17/47 (36%)
		Domain III	1111..1221		9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940