DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and Egf

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_011238312.1	Gene:	Egf / 13645	MGIID:	95290	Length:	1221	Species:	Mus musculus

Alignment Length:	1057	Identity:	236/1057 - (22%)
Similarity:	333/1057 - (31%)	Gaps:	373/1057 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 CREGYTLDPNDYASCLDIDECLESNGGCSEICENLPGEYKCSCQEGYYLDESGKSCVDINECANP 340
            |.|||||. .|...|.|::||...|.||:..|||.||.|.|:|..|:.|...||.|.::..|  |
Mouse   351 CAEGYTLS-RDRKYCEDVNECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQCHELVSC--P 412

  Fly   341 ELSSNCQGACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSA 405
            ...|.|...|.......||:                                    |.:|..|..
Mouse   413 GNVSKCSHGCVLTSDGPRCI------------------------------------CPAGSVLGR 441

  Fly   406 DGTDCQDINECEVDGPEDLDNNAVCQQKC-ENTIGSFRCTCVEGYHLLEDQRSCALD-------- 461
            ||..|        .|....||.. |.|.| ....||:.|.|..||.|..|::|||..
Mouse   442 DGKTC--------TGCSSPDNGG-CSQICLPLRPGSWECDCFPGYDLQSDRKSCAASGPQPLLLF 497

  Fly   462 -----------SCTD---------------------------------LENPQLN---RTRCAHE 479
                       ..||                                 :|...::   |.|...|
Mouse   498 ANSQDIRHMHFDGTDYKVLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANMDGSQRERLITE 562

  Fly   480 CQDLPEG--------------SYRCVCPKGYELSEDQHSCLVQE----------SPCS-----TE 515
            ..|..||              |.:.|. .|.:||...|..::||          .|.:     |:
Mouse   563 GVDTLEGLALDWIGRRIYWTDSGKSVV-GGSDLSGKHHRIIIQERISRPRGIAVHPRARRLFWTD 626

  Fly   516 KGVEKCSPGTCLASEDN---TSFSCICPTGYRSEAFSCQDIDECAEDTHLCS------------- 564
            .|:........|...|.   .|.:.:.|:|.        .||...:..:.|.
Mouse   627 VGMSPRIESASLQGSDRVLIASSNLLEPSGI--------TIDYLTDTLYWCDTKRSVIEMANLDG 683

  Fly   565 ----HTCQNTPGGYQCQCPEGLNLVEEYTCLAE----NLCEVN-NNGCEQICLTARGGVCACREG 620
                ...||..|.     |..|.:.|::..:::    ::..|| ..|..::.|          :|
Mouse   684 SKRRRLIQNDVGH-----PFSLAVFEDHLWVSDWAIPSVIRVNKRTGQNRVRL----------QG 733

  Fly   621 FRLSADG------KSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDE 679
            ..|....      .:....|.||..||||:.:|:...|:..|:|..|:       ::.:
Mouse   734 SMLKPSSLVVVHPLAKPGADPCLYRNGGCEHICQESLGTARCLCREGF-------VKAW------ 785

  Fly   680 CSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFIT-----DSTSSETPSAHTC 739
                     |..:|  |...|..|......|..:   ||||::|...     |.|.|.|..|...
Mouse   786 ---------DGKMC--LPQDYPILSGENADLSKE---VTSLSNSTQAEVPDDDGTESSTLVAEIM 836

  Fly   740 LD----IDECSLANGNC-SHF-CQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQC---SQ 795
            :.    .|:|  ..|.| ||. |.::....:|.|..|:|  .|...|.|||||:.:...|   |.
Mouse   837 VSGMNYEDDC--GPGGCGSHARCVSDGETAECQCLKGFA--RDGNLCSDIDECVLARSDCPSTSS 897

  Fly   796 LCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKL 860
            .|:|..||:.|.|..|:|  .||..|.|||||.:             |.|.|
Mouse   898 RCINTEGGYVCRCSEGYE--GDGISCFDIDECQR-------------GAHNC------------- 934

  Fly   861 SCLDVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRS---ADGC 922
                          |.:..|.|..|.:.|.|.        ||..||.| .||..|..|   .||
Mouse   935 --------------GENAACTNTEGGYNCTCA--------GRPSSPGL-SCPDSTAPSLLGEDG- 975

  Fly   923 APIECN--PGYTLGSDDKCVDIDECQKQNGG-CSHRCSNTEGSFKCSCPPGYELDSDQKTCQDID 984
            ..::.|  ||.....|..|:        ||| |.|  ..:..|:.|:|..||..|    .||..|
Mouse   976 HHLDRNSYPGCPSSYDGYCL--------NGGVCMH--IESLDSYTCNCVIGYSGD----RCQTRD 1026

  Fly   985 ---------ECDQDKTSCITGTC------INEIGGFRCEFPKFPVLPEIPTASSLPESPKIELKT 1034
                     ...|.....:...|      :..:|.:...:.:        |...|...||.....
Mouse  1027 LRWWELRHAGYGQKHDIMVVAVCMVALVLLLVLGMWGTYYYR--------TRKQLSNPPKNPCDE 1083

  Fly  1035 PKYPDFTELSNEIPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPL-------- 1091
            |.    ..:|:..|.:....|....|:|.|..|.|.:. ||...|....|:.|.|..
Mouse  1084 PS----GSVSSSGPNSSSGAAVASCPQPWFVVLEKHQD-PKNGSLPADGTNGAVVDAGLSPSLQL 1143

  Fly  1092 ----------RPEVP-----KSLWV---NQLQPRDLCPRFQAPRNGKSHCNRYR--HKQKLFYYS 1136
                      :|.:.     :|.|:   :...|:::        .|.||...||  ..:||....
Mouse  1144 GSVHLTSWRQKPHIDGMGTGQSCWIPPSSDRGPQEI--------EGNSHLPSYRPVGPEKLHSLQ 1200

  Fly  1137 RCRISCNSGYILQGPEI 1153
            ....||:.    :.|::
Mouse  1201 SANGSCHE----RAPDL 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	16/34 (47%)
		cEGF	396..415	CDD:289433	6/18 (33%)
		FXa_inhibition	425..458	CDD:291342	13/33 (39%)
		FXa_inhibition	476..505	CDD:291342	10/42 (24%)
		vWFA	<550..586	CDD:294047	8/52 (15%)
		FXa_inhibition	596..630	CDD:291342	6/40 (15%)
		FXa_inhibition	636..>664	CDD:291342	11/27 (41%)
		EGF_CA	676..715	CDD:284955	6/38 (16%)
		FXa_inhibition	745..780	CDD:291342	11/36 (31%)
		FXa_inhibition	786..821	CDD:291342	13/37 (35%)
		FXa_inhibition	827..862	CDD:291342	4/34 (12%)
		FXa_inhibition	874..904	CDD:291342	8/29 (28%)
		FXa_inhibition	945..980	CDD:291342	11/35 (31%)
		CCP	1110..1170	CDD:153056	10/46 (22%)
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
Egf	XP_011238312.1	LY	<86..114	CDD:214531
		LY	<125..156	CDD:214531
		LY	158..199	CDD:214531
		FXa_inhibition	370..405	CDD:373209	16/34 (47%)
		FXa_inhibition	418..446	CDD:373209	9/63 (14%)
		FXa_inhibition	453..486	CDD:373209	13/33 (39%)
		LY	514..556	CDD:214531	1/41 (2%)
		LY	557..599	CDD:214531	10/42 (24%)
		LY	600..643	CDD:214531	6/42 (14%)
		LY	643..686	CDD:214531	6/50 (12%)
		LY	687..728	CDD:214531	9/45 (20%)
		FXa_inhibition	755..790	CDD:373209	12/56 (21%)
		EGF_CA	881..921	CDD:311536	17/41 (41%)
		EGF_CA	923..>951	CDD:311536	13/67 (19%)
		PHA02887	<986..1023	CDD:165214	13/50 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000