Protein Alignment frac and LOC1276384

DIOPT Version :10

• Sequence 1: NP_648137.3
• Gene: frac / 38850
• FlyBaseID: FBgn0035798
• Length: 1618
• Species: Drosophila melanogaster
• Sequence 2: XP_061501153.1
• Gene: LOC1276384 / 1276384
• VectorBaseID: AGAMI1_014773
• Length: 2214
• Species: Anopheles gambiae
• Alignment Length: 2150
• Identity: 591/2150 - (27%)
• Similarity: 815/2150 - (37%)
• Gaps: 729/2150 - (33%)

  Fly    17 ASASPSSERKRK---NVMNIPEDPKVSDSLAASLDMSCSSAKIL-PPEINHGRVSVFDRRRRGKK 77
            |:|:.:...|||   ...||.|:..:...|||.||:||.:..:| .|||::|.|..::||::...
Mosquito   111 AAANQAGNGKRKPGQRAQNIQEETDLDPELAARLDLSCMAQGLLRAPEIDNGYVVKYNRRKKAGN 175

  Fly    78 VFLVAFFVCDDNYDFENGISE-MFCSNQKWVDEIPTCI--------PQLNFEEHDEKVGYDLEDY 133
            :||||::.|||.|:.:....: ::||.:||:.:.|.||        .:...:|.:|:.|.:.|||
Mosquito   176 IFLVAYYECDDYYELQPPEHDRLYCSGKKWIGKRPECISTRTGSEDDEEGEDEEEEEEGEEEEDY 240

  Fly   134 SDETVPNDYVENSDIDEDDDEEVSEREPPPPPPPPVVDGADSKPEP------------------- 179
            .:|.     .|.|:...:.|:.|.||........|......|..||
Mosquito   241 EEEG-----EEGSEQPSERDDRVHERVTTTTTTTPATTTTTSTTEPTTTSTTEPTTTTTTTTTST 300

  Fly   180 ------------QIVIEINDDHANEVVESE-------PALAETETE------------------- 206
                        ....|:|......|:|:|       ||...:|.|
Mosquito   301 TEQSTTTSEVPHTTTTEVNVPDNLAVLEAEHETHHHRPATDSSEAEEHEEDEPEDDEEGDDDEEN 365

  Fly   207 --------------NEVLENETPLKAEVQTDVLNSSNASVKVTNDPYEPTFLDNNCGEDNGGCAH 257
                          ||.:|...||:....|....::..:.:.|..|..|.....:||.|.|||.|
Mosquito   366 EHDHRETHKVDESYNEEIEQRKPLEHPSSTATTTTTTTTTESTVVPTTPQTYVADCGPDRGGCDH 430

  Fly   258 ICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLESNGGCSEICENLPGEYKCSCQEGY 322
            .|:.:.:.:|.:|:.:|.|..|:.||..|..:|.|:|||.::||||.:.|.|.||.|:|.|:.|.
Mosquito   431 ECRMIYHGNEVEPLVECSCYRGFLLDARDGRTCHDVDECADNNGGCEQTCINKPGSYECGCEPGL 495

  Fly   323 YLDE-SGKSCVDINECANPELSSNCQGACENLPGSYRCV---------EPLEENPEITE------ 371
            .:|. :|.:|:||:||.|......|...|||..|||||:         ||.||..|..|
Mosquito   496 QIDTLNGHTCIDIDECQNEATLERCADGCENTFGSYRCLERSKPHEDDEPAEEEEEEEEEEEGEG 560

  Fly   372 -------------------------VVENPI---------------------------EKTNE-- 382
                                     :.||.:                           |:.||
Mosquito   561 EDESENEDGGEQGRESDKHTEAHNRLSENELPQEAHQSVESAGSDEETSRHRAEDTSAERENETE 625

  Fly   383 ------VP--------------------------------------------------------- 384
                  ||
Mosquito   626 AIPDVTVPPIRTSTHAHRHHHGEERPLPEPGHENREPIDRETDREEEVDEGEEEEDEHEEEEEED 690

  Fly   385 ----------------------------------------------------------------- 384
                                                                             
Mosquito   691 STPERVDRVEQPTPVASSGDSHTAISTSDEEQDREDQDSDYEEEEDDGRDERPTVQVAPSIHCDE 755

  Fly   385 -------------VNVSESQPAG------------KTCNSGFQLSADGTDCQDINECEV-DGPED 423
                         :|..|.|..|            .||.:|::|:.:...|||::||.. |..|.
Mosquito   756 GLRWNPTTGTCEDINECEEQEHGCDYCQNAFGGYQCTCPAGYELADNDKHCQDVDECAASDDDES 820

  Fly   424 LDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCALDSCTDL-ENPQLNRTRCAHECQDLPEGS 487
            .:..:.|..:|.||:|||.|.|.:.:||..|:|:|..|.|.|| |||  |:|||:|||.|..||
Mosquito   821 GEGGSACSHECHNTVGSFECRCPDAFHLNNDRRTCVRDFCQDLYENP--NKTRCSHECVDEVEG- 882

  Fly   488 YRCVCPKGYELSEDQHSCLVQESPCSTEKGVEK-----CSPGTCLASEDNTSFSCICPTGYRSEA 547
            :||.||.||.|.|      |.:..|..|:|..|     |.||.||..|  :.:.|.||.||....
Mosquito   883 FRCHCPDGYLLDE------VDQKTCRAEEGCNKHQRRHCEPGRCLRME--SDYRCECPEGYVQGQ 939

  Fly   548 FSCQDIDECAEDTHLCSHTCQNTPGGYQCQCPEGLNL---------------------------- 584
            .|||:.|||....|.|||.|.||||.|:|.||.||.|
Mosquito   940 HSCQERDECMPGQHDCSHECHNTPGSYRCACPAGLTLSADGKTCDDVNECERETNELDGVCGDLE 1004

  Fly   585 -----------------VEEY------------------------------------------TC 590
                             ::||                                          ||
Mosquito  1005 CRNTYGSYKCVCPEGRELDEYGICRQMDLCRKDNGGCSHICTFYNRETYCDCPDDMELAEDGKTC 1069

  Fly   591 LAENLCEVNNNGCEQICLTARGGVCACREGFRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYG 655
            ...|||.|||.||..||......||.|..|..|..||::||||:||..:||||.|.|.|..|.|.
Mosquito  1070 ETTNLCGVNNGGCSHICDQDSETVCLCPAGMVLGGDGRTCEDVNECETDNGGCSQSCLNYEGGYR 1134

  Fly   656 CICAAGYELLKLDGIRGYCFDIDECSQ-RTHGCSDQMLCENLNGSYTCLCPPGYAL--------- 710
            |.|..||||::.|  |..|.|.|||:. |..||...  |.|..|||.|.|..||.|
Mosquito  1135 CSCYEGYELVESD--RRTCVDRDECANARGGGCDHN--CHNTAGSYYCTCHAGYKLAENARTCMD 1195

  Fly   711 --------GLDNHIVTSL-------------------NSSFITDSTSSETPSAH----------- 737
                    |..:|:..:|                   ...|:.:...:....:|
Mosquito  1196 VNECEERNGNCSHVCINLLGGHQCSCPKGLFLQEDDRTCDFVDECELNNGGCSHGCHYEYGVVSC 1260

  Fly   738 --------------TCLDIDEC-SLANGNCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECL 787
                          ||:|:||| |..||.|||.|.|.||.::|.||.||.|..|...|||:|||:
Mosquito  1261 SCPKGFQLDSEHQKTCVDVDECASRGNGGCSHECVNSPGSYECRCPDGYELRHDRHACQDVDECI 1325

  Fly   788 DSNGQCSQLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNCSDICINLLGTHACACERG 852
            ..||.||.:|:|.|||..||||.|:.|..|...|:|:|||:....:||..|:|:.|.:.|.|..|
Mosquito  1326 VENGNCSNICINLPGGHRCACEIGYSLQDDQRTCSDVDECNDGTHDCSHHCVNVPGAYECECPAG 1390

  Fly   853 YELAKDKLSCLDVDECAGLLS-GGCSHECINKAGTFECGCPLGYILNDDGRSCSPA--------- 907
            ::|.:::|||.|||||..|.: |.|.|.|||..|::.|||..|:.|..:.|:||..
Mosquito  1391 FKLGRNRLSCEDVDECETLPNRGDCEHRCINTIGSYHCGCEDGHRLEANNRTCSDVDECSDELRT 1455

  Fly   908 ------------LVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDECQ--KQNGGCSHRCSN 958
                        :..||.|.:...||.:               |||:|||:  ..|.||||.|.|
Mosquito  1456 CTHDCVNTKGGFVCSCPSGLRLDVDGVS---------------CVDVDECRINNFNAGCSHICEN 1505

  Fly   959 TEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCE-FPKFPVLP-----E 1017
            |.|||:|.||.|..|..||.||.|:|||......| :..|:|..||:||. .|.:.::.     |
Mosquito  1506 THGSFECRCPEGMVLGDDQATCSDVDECAVLNGGC-SQLCVNRDGGYRCGCHPGYTLMADGKACE 1569

  Fly  1018 IPTASSLPE------------SPKIELKTPKYPDFTELSNEIPENPKKPAEFDYPEPKFPSLPK- 1069
            :....:|..            .|....:.....:.|..::.|..|....|:....:.:..:|..
Mosquito  1570 VSNPCALRNGGCQHYCSLKGGQPVCSCREGYTLNKTNQASCIDHNECLQAKDHNCQQRCVNLEGS 1634

  Fly  1070 -----WEGLPK--LPPLADIPT--------------------SKAPVPL-------RPEVPKSLW 1100
                 :||..:  |....||..                    |:...|:       |....|.
Mosquito  1635 YRCECYEGYERNDLEQCIDINECAIDNGGCGAGAQCVNTAGGSRCACPVGFKLTQDRKHCAKL-- 1697

  Fly  1101 VNQLQPRDLCPRFQAPRNGKSHCNRYRHKQKLFYYSRCRISCNSGYILQGPEIKSCDANGIWEGP 1165
                  .|.|..|:||||.:..|.|.|||.:|||.|:|.::|..|:.|.||.::.|:..|.|:..
Mosquito  1698 ------TDNCKPFEAPRNAEVRCTRSRHKTQLFYRSKCIVTCKKGFKLHGPSVRHCNGTGEWDEG 1756

  Fly  1166 ETKCVAINQPRAQSPGICPALKPAQNGVILPASCTQGPSRFGDVCRLQCNAGFVSTGSLLTACMM 1230
            |:.||         |..||.|...:||||||.:||.|.....:.|.|.|..||.........|.:
Mosquito  1757 ESICV---------PLACPRLSRPENGVILPVACTAGKIFASERCVLHCKPGFKPAARRTAVCSL 1812

  Fly  1231 LQGWSFGADLNCQPFGNGLLGNQLSPMWNSPK---TVTPHQIQNVEQIRPYINCPENVVILLHAG 1292
            .|.|..|.:|.|.|     |.:.:.|    ||   |.||..:..| .|:|:|.||.:|..:|..|
Mosquito  1813 AQTWVPGDNLACVP-----LDSPVVP----PKQLTTTTPTTVPPV-AIKPFIQCPPDVHEVLPLG 1867

  Fly  1293 EQKAHVTLQRPQTNVKNGRLV-AHPAWAGQLQGHLPAGVHKVDFRVNDPETKLTIKCHTIITVKA 1356
            :....|.::||.|||...:.| :||.|..||:..||||...|.||...|...:...|..:|.:
Mosquito  1868 QYTMKVRMERPTTNVDWHKYVDSHPPWGKQLEVELPAGETIVTFRARSPTGNVNDVCRVVIKI-- 1930

  Fly  1357 ATPRESNPFTLFRISDYSRSSLPRPAPFATLSTGSSFSFPAFKALDATPKPVSFTKFQVFPDSES 1421
               ||..|.|:.
Mosquito  1931 ---RERKPPTVV----------------------------------------------------- 1939

  Fly  1422 SEHSKLGSSSFFRLEPLFHESSKLISAAPASSENTRVDLGSDTSNYCPPSIEVYLKENQNLRSVV 1486
                                                         :||.|.||.|:..:..|||.
Mosquito  1940 ---------------------------------------------HCPESFEVQLERGEPSRSVF 1959

  Fly  1487 WDEPRFE--GKLLKIYKSHFPGSLFKVGDHAIKYEATTTDGKTLSCTFFIYVRSAKPTPAPTEPK 1549
            |.||:||  .::.::|||:.||....||.|.:.|.||..||.:.:|.|.:.|::| |...| ||:
Mosquito  1960 WTEPKFESQSEIKQLYKSNTPGQPLSVGSHYVNYIATDADGLSANCNFRVVVKAA-PVEVP-EPR 2022

  Fly  1550 ISFDS-EPETLSDVS--QTYVVCPDKEPVRVTAESVSL--PVGCTLKNIRPKSRSPKELKRGKLT 1609
            ....: .|..:|.:.  ::|::||.|.|||:...:..|  |.||.:||||.|.         ||.
Mosquito  2023 RPLGAGRPAEMSRLENHESYLICPGKPPVRLDGNNYPLHVPQGCVVKNIRIKQ---------KLA 2078

  Fly  1610 SLWHQ 1614
            .|.||
Mosquito  2079 RLRHQ 2083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_648137.3	FXa_inhibition	296..331	CDD:464251	15/35 (43%)
		cEGF	396..415	CDD:463661	7/18 (39%)
		FXa_inhibition	425..458	CDD:464251	13/32 (41%)
		FXa_inhibition	476..505	CDD:464251	15/28 (54%)
		EGF_CA	552..>581	CDD:214542	16/28 (57%)
		FXa_inhibition	596..630	CDD:464251	15/33 (45%)
		FXa_inhibition	636..>664	CDD:464251	14/27 (52%)
		EGF_CA	676..711	CDD:214542	17/52 (33%)
		FXa_inhibition	745..780	CDD:464251	18/35 (51%)
		FXa_inhibition	786..821	CDD:464251	17/34 (50%)
		vWFA	<821..861	CDD:469594	14/39 (36%)
		FXa_inhibition	874..904	CDD:464251	13/29 (45%)
		FXa_inhibition	945..980	CDD:464251	19/36 (53%)
		PTZ00449	<1017..>1098	CDD:185628	16/127 (13%)
		CCP	1110..1170	CDD:153056	25/59 (42%)
		CCP	1183..1235	CDD:153056	19/51 (37%)
		HYR	1468..1536	CDD:460572	29/69 (42%)
LOC1276384	XP_061501153.1	None