DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frac and thbd

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_017208183.1	Gene:	thbd / 108180329	ZFINID:	ZDB-GENE-110411-281	Length:	515	Species:	Danio rerio

Alignment Length:	442	Identity:	124/442 - (28%)
Similarity:	166/442 - (37%)	Gaps:	133/442 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   626 DGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYE------LLKLD------GIRGYCFDID 678
            ||| |..|.....|....|:||....|....|..|...      |||.:      |:|   :..:
Zfish    26 DGK-CFVVQTDTANFDAAQKVCEERTGHLMTIRTAKLADVLSRLLLKGESGNFWIGLR---YVGN 86

  Fly   679 ECSQRTHG---------------------------------------CSDQM---LCE--NLNGS 699
            |||.|..|                                       |||::   :||  |||.
Zfish    87 ECSDRLKGYKWITGDDTSHFSNWKRESDCAPSCVSVSQNDHKWTERPCSDRIDGYVCEYNNLNH- 150

  Fly   700 YTCLCPPGYALGLDNHIVTSLNSSF-----------ITDSTSSETPSAHTCLDID------ECSL 747
                |||   |..|..:..|....|           :|::|..:..:.|.|.|.:      .|.:
Zfish   151 ----CPP---LSTDEKVHYSTAFGFTSNELLREIPELTNATRLDLRTKHICFDSEWLHAPWNCEV 208

  Fly   748 ANGNCSHFCQNEPGGFQCACPLGYALSEDMRTC---QDIDECLDSNGQCSQLCLNQPGGFACACE 809
            .:|.|.:.|......:.|.|..|:.|..:..:|   ||.|.|  ::..|...|....|.|||.|.
Zfish   209 FDGGCDYTCVRNGQSYACICQPGFKLDTNGISCSQQQDDDPC--AHAGCEHECARDSGAFACTCR 271

  Fly   810 TGFELTPDGFGCADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSG 874
            .||.|:.||..|.:         ||....||         |.|        .|:||||||   :|
Zfish   272 PGFTLSADGKSCKE---------NCKPGYIN---------ENG--------GCVDVDECA---TG 307

  Fly   875 GCSHECINKAGTFECGCPLGY-ILNDDGRSCSPALVGCPPGTQRSADGCAP-----IECNPGYTL 933
            .|.|:|.|..|:::|.|..|| ....|...|.   :.||  ..|....|.|     .:|..|:..
Zfish   308 PCEHDCANTEGSYQCVCFDGYKPAAKDMHKCK---MHCP--DMRCKAECDPNNDYQCDCPDGFLF 367

  Fly   934 GSDDK-CVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTCQDID 984
            ..||: |||:|||...| .|...|:||.|||:|.|..||.| .|...|:|::
Zfish   368 DEDDRYCVDVDECISTN-DCDQNCTNTPGSFECFCHEGYVL-LDNGVCEDLE 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433
		FXa_inhibition	425..458	CDD:291342
		FXa_inhibition	476..505	CDD:291342
		vWFA	<550..586	CDD:294047
		FXa_inhibition	596..630	CDD:291342	3/3 (100%)
		FXa_inhibition	636..>664	CDD:291342	7/33 (21%)
		EGF_CA	676..715	CDD:284955	18/82 (22%)
		FXa_inhibition	745..780	CDD:291342	8/34 (24%)
		FXa_inhibition	786..821	CDD:291342	13/34 (38%)
		FXa_inhibition	827..862	CDD:291342	6/34 (18%)
		FXa_inhibition	874..904	CDD:291342	11/30 (37%)
		FXa_inhibition	945..980	CDD:291342	15/34 (44%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
thbd	XP_017208183.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910