DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and Ltbp4

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_783572.2	Gene:	Ltbp4 / 108075	MGIID:	1321395	Length:	1666	Species:	Mus musculus

Alignment Length:	1333	Identity:	345/1333 - (25%)
Similarity:	463/1333 - (34%)	Gaps:	494/1333 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 PPPPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPALAETETENEVLENETPLKAEVQTDVL 225
            |.|.|.|......:|:|.|               ||:|            ..|.||
Mouse   543 PEPRPQPESQPRPESRPRP---------------ESQP------------WPEFPL--------- 571

  Fly   226 NSSNASVKVTNDPYEPTFLDNNCGEDNGGCAHICKRLLYPDENQPINKCDCREGYTLDPNDYASC 290
                .|:.....|..|         ::|..:.:|:|          |...|..|.
Mouse   572 ----PSIPAWTGPEIP---------ESGPSSSMCQR----------NPQVCGPGR---------- 603

  Fly   291 LDIDECLESNGGCSEICENLPGEYKCSCQEGYYLDESGKSCVDINECANPELSSNC-QGACENLP 354
                            |...|..|.|:|..|:.|...|..|:||:||.  .:.:.| .|.|||.|
Mouse   604 ----------------CVPRPSGYTCACDPGFRLGPQGTRCIDIDECR--RVPTPCAPGRCENTP 650

  Fly   355 GSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINEC-EV 418
            ||:|||                                    |.:|||.....|:|.|::|| .|
Mouse   651 GSFRCV------------------------------------CGTGFQAGPRATECLDVDECRRV 679

  Fly   419 DGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQRSCA-LDSCTDLENPQLNRTRCAH-ECQ 481
            ..|.|       :.:||||.|||.|.|..||.......||. :|.||  ::|.|    |.. .|:
Mouse   680 PPPCD-------RGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECT--QSPGL----CGRGVCE 731

  Fly   482 DLPEGSYRCVCPKGYELS---EDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNT--SFSCICPT 541
            :|| ||:|||||.|:..|   ||...|..|..|         |.||.|    |||  ||.|.||.
Mouse   732 NLP-GSFRCVCPAGFRGSACEEDVDECAQQPPP---------CGPGRC----DNTAGSFHCACPA 782

  Fly   542 GYRSE--AFSCQDIDECAEDTHLCSH-TCQNTPGGYQCQCPEG---------------------- 581
            |:||.  ...|||:|||:.....|:: .|:||.|.::|.||.|
Mouse   783 GFRSRGPGAPCQDVDECSRSPSPCAYGRCENTEGSFKCVCPTGFQPNAAGSECEDVDECENRLAC 847

  Fly   582 -----LNLVEEYTCLAENLCEVNNN------------------GCEQICLTARGGV-CACREGFR 622
                 :|....:.|.|   |.|.::                  |....|...:|.. |:|..|:|
Mouse   848 PGQECVNSPGSFQCRA---CPVGHHLHRGRCTDVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 909

  Fly   623 L-SADGKSCEDVDECLVNNGGC--QQVCRNLPGSYGCICAAGYELLKLDGIRG-YCFDIDECSQR 683
            . |.....|.|::||| ....|  ...|.|..||:.|.||.||.    .|.|| .|.|:||||:
Mouse   910 APSGQPGPCADINECL-EGDFCFPHGECLNTDGSFTCTCAPGYR----PGPRGASCLDVDECSE- 968

  Fly   684 THGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDEC-SL 747
             .......:|.|.:||:.|:||||:..|                      |...:||||||| ..
Mouse   969 -EDLCQSGICTNTDGSFECICPPGHRAG----------------------PDLASCLDIDECRER 1010

  Fly   748 ANGNC-SHFCQNEPGGFQCA--CPLGYALSEDMRTCQDIDECLD-SNGQC-SQLCLNQPGGFAC- 806
            ....| |..|:|.||.::|.  |..||....: .||.|||||.: .:..| :|.|.|.||.:.|
Mouse  1011 GPALCGSQRCENSPGSYRCVRDCDPGYHPGPE-GTCDDIDECREYGSAICGAQRCENTPGSYRCT 1074

  Fly   807 -ACETGFELTPDGFGCADIDEC-SQDYGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECA 869
             ||:.|::.||.| ||.|:||| ::.:.....:|.||.|:..|.|::|||.|:|...|:||:||.
Mouse  1075 PACDPGYQPTPGG-GCQDVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGARDGRHCVDVNECE 1138

  Fly   870 GLLSGGC-SHECINKAGTFECGCPLGYILND-------DGRSCSP-ALVGCPPGTQRSA------ 919
             .|.|.| |..|.|..|:|.|.||     |.       .||...| |..|..||:|..|
Mouse  1139 -TLQGVCGSALCENVEGSFLCVCP-----NSPEEFDPMTGRCVPPRAPAGTFPGSQPQAPASPSL 1197

  Fly   920 ------------------------------DGCAPIECN-------------------------- 928
                                          |..||..|:
Mouse  1198 PARPPAPPPPRRPSPPRQGPVSSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRI 1262

  Fly   929 ------------------PGYTLGSDDKCV--DIDECQK-QNGGC-SHRCSNTEGSFKCSCPPGY 971
                              .||.:.|.|...  |:||||. |:..| |..|.||...:.|.|..|:
Mouse  1263 QQCPGTETAEYQSLCPHGRGYLVPSGDLSARRDVDECQLFQDQVCKSGVCVNTAPGYSCYCSNGF 1327

  Fly   972 ELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEIP-------------TASS 1023
            ...:.:..|.|.|||..::.:|..|.|:|.:|.:.|..       |.|             .:.|
Mouse  1328 YYHAHRLECVDNDECADEEPACEGGRCVNTVGSYHCTC-------EPPLVLDGSRRRCVSNESQS 1385

  Fly  1024 LPES---------PKIELKTPKY-----------------------------PDFTELSNEI--- 1047
            |.::         |.:....|:.                             .||..|.|.:
Mouse  1386 LDDNLGVCWQEVGPDLVCSRPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPP 1450

  Fly  1048 PENPKKPAEFDYPEPKFPSL-PKWEGLPKLP---PLADIPTSKAPVP----LRPEVPKSLWVNQL 1104
            ...|.:|..|..|....|.: |.::.||..|   |...:|....|.|    .|.|.|..     .
Mouse  1451 AYGPPRPGGFGIPYEYGPDIGPPYQSLPYGPDLYPPPVLPYDPYPPPPGPFARREAPYG-----A 1510

  Fly  1105 QPRDLCPRFQ-------------APRNGKSHCNRYRHKQKLF----------YYS---------- 1136
            .|.|: |.|:             .|..|.....|.|..:..|          .|:
Mouse  1511 PPFDM-PDFEDDGGPYGESETPDPPSRGTGWPYRSRDTRGSFPEPEESSERGSYTGALSEPYEGL 1574

  Fly  1137 ---RCRI--SCNSGYILQGPEIKSCDANGIWEG-----PETKCVAIN---QPRAQSPGICPALKP 1188
               .|.|  .|..|..::.||..:||.   ::|     ....||.:|   :..|.|| :|
Mouse  1575 EAEECGILDGCPHGRCVRVPEGFTCDC---FDGYRLDITRMSCVDVNECDEAEATSP-LC----- 1630

  Fly  1189 AQNGVILPASCTQGPSRFGDVCRLQCNAGFVST 1221
                  :.|.|......|..:||    .||..|
Mouse  1631 ------VNARCVNTDGSFRCICR----PGFAPT 1653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	8/34 (24%)
		cEGF	396..415	CDD:289433	7/18 (39%)
		FXa_inhibition	425..458	CDD:291342	11/32 (34%)
		FXa_inhibition	476..505	CDD:291342	15/32 (47%)
		vWFA	<550..586	CDD:294047	16/63 (25%)
		FXa_inhibition	596..630	CDD:291342	10/53 (19%)
		FXa_inhibition	636..>664	CDD:291342	12/29 (41%)
		EGF_CA	676..715	CDD:284955	15/38 (39%)
		FXa_inhibition	745..780	CDD:291342	11/38 (29%)
		FXa_inhibition	786..821	CDD:291342	14/38 (37%)
		FXa_inhibition	827..862	CDD:291342	12/35 (34%)
		FXa_inhibition	874..904	CDD:291342	13/37 (35%)
		FXa_inhibition	945..980	CDD:291342	11/36 (31%)
		CCP	1110..1170	CDD:153056	17/102 (17%)
		CCP	1183..1235	CDD:153056	9/39 (23%)
		DUF5011	1468..1536	CDD:295940
Ltbp4	NP_783572.2	EGF_CA	356..>386	CDD:214542
		TB	417..452	CDD:279073
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..590		17/95 (18%)
		cEGF	610..633	CDD:289433	9/22 (41%)
		EGF_CA	630..666	CDD:214542	19/73 (26%)
		EGF_CA	672..713	CDD:214542	18/47 (38%)
		EGF_CA	714..751	CDD:238011	18/43 (42%)
		EGF_CA	753..787	CDD:238011	18/46 (39%)
		EGF_CA	795..836	CDD:214542	13/40 (33%)
		EGF_CA	877..909	CDD:238011	6/31 (19%)
		EGF_CA	920..956	CDD:214542	15/40 (38%)
		EGF_CA	962..997	CDD:214542	15/58 (26%)
		EGF_CA	1003..1041	CDD:214542	15/37 (41%)
		EGF_CA	1091..1132	CDD:214542	15/40 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1171..1221		9/49 (18%)
		TB	1235..1272	CDD:279073	1/36 (3%)
		EGF_CA	1338..>1367	CDD:238011	10/35 (29%)
		TB	1403..1439	CDD:279073	1/35 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1488..1566		16/83 (19%)
		EGF_CA	1616..>1650	CDD:214542	10/49 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42398
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020