DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and fbn2

DIOPT Version :10

Sequence 1:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:XP_002931771.2 Gene:fbn2 / 100494368 XenbaseID:XB-GENE-494557 Length:2891 Species:Xenopus tropicalis


Alignment Length:1485 Identity:375/1485 - (25%)
Similarity:517/1485 - (34%) Gaps:581/1485 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 KNVMNIPE---DPKVSD-----SLAASLDMSCSSAKILPP------EINHGRVSVFDRR-RRGKK 77
            ||.|:|.|   :|.:..     :...|...:|.:...|.|      :||...:|  |.. |.||.
 Frog  1126 KNCMDIDECERNPLLCRGGECINTEGSFLCNCPNGHELTPSGDACVDINECALS--DNLCRNGKC 1188

  Fly    78 VFLVAFFVCDDNYDFENGISEMFCSNQKWVDEIPTC-IPQLNFEEH--DEKVGYD---LEDYSDE 136
            |.:|..:.|..|..::..:..:.|::   :||   | |.....:.|  :.:..|:   ||.|:  
 Frog  1189 VNIVGTYQCSCNPGYQATLDRLGCTD---IDE---CTIMNGGCDTHCTNSEGSYECSCLEGYA-- 1245

  Fly   137 TVPNDYVENSDIDEDDDEEVSEREPPPPPPPPVVDGADSKPEP-----------------QIVIE 184
            .:| |....:||||.:|.            |.:.||......|                 :..|:
 Frog  1246 LMP-DKRTCTDIDECEDN------------PDICDGGQCTNIPGEYRCLCFDGFMASMDMKTCID 1297

  Fly   185 INDDHANEVV----ESEPAL-------------------------AETETENEVLEN---ETP-- 215
            :|:...|..:    |.|...                         .|.:|.|..|..   ..|  
 Frog  1298 VNECDINSNICMFGECENTKGSFVCHCQVGYAVKKGTTGCTDVDECEIDTHNCHLHATCLNVPGS 1362

  Fly   216 -------------LKAEVQTDVLNSS---NASVKVTNDP--YEPTFLDNNCGEDNGGCAHI--CK 260
                         :|.....:.||.:   :.|....|.|  |..:..:...| |...|:.:  |.
 Frog  1363 FKCTCKEGWIGNGIKCNDLDECLNGTHRCSVSAHCLNTPGSYHCSCAEGYTG-DGFTCSDVDECT 1426

  Fly   261 RLLYPDEN-QPIN-----KCDCREGYTLDPNDYASCLDIDECLESNGGCSEICENLPGEYKCSCQ 319
            ..:...|| |.:|     :|:|..|:| ..:|..||.|||||...|......|.||||.::|.|.
 Frog  1427 ENINLCENGQCLNIPGSYRCECDMGFT-PASDSRSCQDIDECAFQNICVFGTCSNLPGMFRCICN 1490

  Fly   320 EGYYLDESGKSCVDINECANPELSSNC-QGACENLPGSYRCVEP--LEENPEITEVV-------- 373
            |||.||.:|.:|.|::|||:|   .|| .|.|.|.||.|.|..|  .:.||.....|        
 Frog  1491 EGYELDRTGGNCTDVDECADP---INCVNGFCVNTPGRYECNCPPDFQLNPTGVGCVDTRVGNCY 1552

  Fly   374 -------ENPIEKTNEVPVNVSES-------QPAGKTC------NS-----------GFQLSADG 407
                   :..|..:.|:.|.||.|       :..|..|      ||           ||:.:...
 Frog  1553 LNHGARGDGTISCSTEIGVGVSRSSCCCSLGKAWGNPCEICPPVNSSEYNTLCPGGEGFRPNPIT 1617

  Fly   408 TDCQDINEC-EVDGPEDLDNNAVCQ-QKCENTIGSFRCTCVEGYHLLEDQRSCA-LDSCTDLENP 469
            ...:||:|| |:.|        :|| ..|.||.|||:|.|.:||:|.|:.|.|. :|.|  ..:|
 Frog  1618 IILEDIDECQELPG--------LCQGGNCINTFGSFQCECPQGYYLSEETRICEDIDEC--FTHP 1672

  Fly   470 QLNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSCL-VQES----------------------- 510
            .:    |.........|:|.|:||..|......|:|: :::|                       
 Frog  1673 GV----CGPGTCYNTLGNYTCICPSEYMQVNGGHNCMDMRKSFCYRTYNGTTCDNELPFNVTKKM 1733

  Fly   511 ----------------PCST------------------------EKGVEKCS--PGTC---LASE 530
                            ||.|                        ...:::|.  ||.|   :...
 Frog  1734 CCCTYNIGKAWSKPCEPCPTPGTANFKHLCGSIPGFTFDIHTGKAVDIDECKEIPGICTNGVCIN 1798

  Fly   531 DNTSFSCICPTG--YRSEAFSCQDIDECAEDTHLCSHT--CQNTPGGYQCQCPEGLNLVEEYTCL 591
            ...||.|.||||  |......|:|||||:...:.|...  |.|:||.|:|:|..|..|:....|:
 Frog  1799 QIGSFRCECPTGFSYNDLLLVCEDIDECSSGDYFCQRNADCINSPGTYRCECSTGFKLLPNGACI 1863

  Fly   592 AENLC-EVNNNGCEQICLTARGGV-CACREGFRLSADGKSCEDVDEC---LVNNGGCQ------- 644
            ..|.| |:.|......|:...|.. |.|..||::|.|...|.|:|||   ...||.|:       
 Frog  1864 DRNECLEIPNVCSHGTCVDTEGSYHCVCNNGFKVSPDQTMCMDIDECERQPCGNGTCKNTVGSYN 1928

  Fly   645 --------------------------QVCR-----NLPGSYGCICAAGYELLKLDGIRGYCFDID 678
                                      ||||     |..||:.|:|..||||.. ||..  |.||:
 Frog  1929 CLCYPGFEITHNNDCLDIDECSSLYGQVCRNGHCFNEIGSFICLCNEGYELTP-DGKN--CIDIN 1990

  Fly   679 ECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDID 743
            ||......||.. .|:||.||:.|:|||||.:..:|                        |:|||
 Frog  1991 ECVAFPGSCSPG-TCQNLEGSFRCICPPGYEVEREN------------------------CIDID 2030

  Fly   744 ECSLANGNCSHF--CQNEPGGFQCACPLGYALSEDMRTC-------------------------- 780
            || :...|...|  |.|.||.|||.||.|:.|||:.|.|                          
 Frog  2031 EC-IEEPNICLFGACSNTPGSFQCICPPGFVLSENGRRCFDTRQSFCFTRFENGKCSVPKAYNST 2094

  Fly   781 -----------------------------------------------QDIDECLDSNGQCSQ-LC 797
                                                           :|::|||::.|.|:. .|
 Frog  2095 KAKCCCSKMPGEGWGDPCELCPKEGEVAFQDLCPYGHGTIPGIGDTREDVNECLENPGICANGHC 2159

  Fly   798 LNQPGGFACACETGFELTPDGFGCADIDECSQDYGN-CSD-ICINLLGTHACACERGYELAKDKL 860
            :|..|.|.|.|..|:.|...|..|.|.||||  .|| |.: .|.|.:||..|.|:.|:| ....:
 Frog  2160 INTDGSFRCECPMGYNLDYTGVNCVDTDECS--IGNPCGNGTCTNAIGTFECLCDEGFE-PGPMM 2221

  Fly   861 SCLDVDECA--GLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPA---------------- 907
            .|.|::||.  .||   |:..|||..|.:||.||.||||.:|.:.|...                
 Frog  2222 VCEDINECILNPLL---CAFRCINTYGAYECTCPAGYILREDQKMCKDLDECIEGFHDCESRGMV 2283

  Fly   908 ---LVG-----CPPGTQRSADG------------------------------------------- 921
               |:|     ||||..|..||                                           
 Frog  2284 CKNLIGTFMCICPPGMVRRPDGEGCMDENECRTKPGICENGRCVNTIGSYRCDCNEGFQSTPSGT 2348

  Fly   922 ---------------------------------------------C--APIE------------- 926
                                                         |  .|:.             
 Frog  2349 ECLDTRQGFCFSEVLQTMCQMSSSSRNHVTKSECCCNGGRGWGNQCEICPLPGTAQYKKMCPHGP 2413

  Fly   927 ----------------------------------CNPGYT--LGSDDKCVDIDECQKQNGGCSHR 955
                                              ||||||  :|. ..|||:|||.:....|:..
 Frog  2414 GYTTDGKDIDECKVMPNLCRNGQCINNIGSYRCFCNPGYTTDIGG-TACVDLDECSQSPKPCNFI 2477

  Fly   956 CSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFP 1010
            |.|||||::||||.||.|..|.|:|:|:|||...:.:| ...|:|.||||.|:.|
 Frog  2478 CKNTEGSYQCSCPRGYILQEDGKSCKDLDECQTKQHNC-QFLCVNTIGGFTCKCP 2531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 15/34 (44%)
cEGF 396..415 CDD:463661 7/35 (20%)
FXa_inhibition 425..458 CDD:464251 15/33 (45%)
FXa_inhibition 476..505 CDD:464251 8/28 (29%)
EGF_CA 552..>581 CDD:214542 13/30 (43%)
FXa_inhibition 596..630 CDD:464251 11/35 (31%)
FXa_inhibition 636..>664 CDD:464251 15/68 (22%)
EGF_CA 676..711 CDD:214542 17/34 (50%)
FXa_inhibition 745..780 CDD:464251 17/36 (47%)
FXa_inhibition 786..821 CDD:464251 13/35 (37%)
vWFA <821..861 CDD:469594 17/41 (41%)
FXa_inhibition 874..904 CDD:464251 14/29 (48%)
FXa_inhibition 945..980 CDD:464251 17/34 (50%)
PTZ00449 <1017..>1098 CDD:185628
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
HYR 1468..1536 CDD:460572
fbn2XP_002931771.2 Fibrillin_U_N 66..102 CDD:436338
EGF_CA 308..349 CDD:214542
TB 363..407 CDD:459903
EGF_CA 507..537 CDD:214542
EGF_CA 547..587 CDD:214542
EGF_CA 589..629 CDD:214542
EGF_CA 630..670 CDD:214542
TB 685..728 CDD:459903
EGF_CA 782..817 CDD:238011
TB 877..>909 CDD:459903
EGF_CA 927..957 CDD:429571
TB 982..1024 CDD:459903
EGF_CA 1087..1121 CDD:214542
EGF_CA 1130..1162 CDD:214542 5/31 (16%)
EGF_CA 1172..1204 CDD:214542 11/33 (33%)
FXa_inhibition 1218..1253 CDD:464251 9/37 (24%)
EGF_3 1343..1378 CDD:463759 5/34 (15%)
EGF_3 1384..1419 CDD:463759 8/35 (23%)
EGF_CA 1421..1453 CDD:214542 8/31 (26%)
EGF_CA 1463..1497 CDD:238011 17/33 (52%)
EGF_CA 1504..1535 CDD:214542 15/33 (45%)
TB 1565..1605 CDD:459903 9/39 (23%)
EGF_CA 1622..1654 CDD:214542 17/39 (44%)
TB 1720..1763 CDD:459903 3/42 (7%)
EGF_CA 1780..1812 CDD:214542 11/31 (35%)
vWFA <1819..1860 CDD:469594 16/40 (40%)
vWFA <1855..1901 CDD:469594 13/45 (29%)
EGF_CA 1906..1940 CDD:214542 7/33 (21%)
EGF_CA 1945..1987 CDD:214542 15/44 (34%)
EGF_CA 1988..2020 CDD:214542 16/32 (50%)
EGF_CA 2028..2068 CDD:214542 21/40 (53%)
TB 2083..2127 CDD:459903 0/43 (0%)
EGF_CA 2143..2173 CDD:429571 12/29 (41%)
EGF_CA 2185..2219 CDD:214542 16/36 (44%)
EGF_CA 2266..2298 CDD:429571 4/31 (13%)
EGF_CA 2310..2343 CDD:214542 0/32 (0%)
TB <2376..2409 CDD:459903 2/32 (6%)
EGF_CA 2421..2454 CDD:214542 5/32 (16%)
FXa_inhibition 2467..2502 CDD:464251 17/34 (50%)
EGF_CA 2504..2533 CDD:429571 13/29 (45%)
EGF_CA 2586..>2615 CDD:214542
EGF_CA 2626..2657 CDD:214542
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.