DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and fbn2

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:XP_002931771.2 Gene:fbn2 / 100494368 XenbaseID:XB-GENE-494557 Length:2891 Species:Xenopus tropicalis


Alignment Length:1485 Identity:375/1485 - (25%)
Similarity:517/1485 - (34%) Gaps:581/1485 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 KNVMNIPE---DPKVSD-----SLAASLDMSCSSAKILPP------EINHGRVSVFDRR-RRGKK 77
            ||.|:|.|   :|.:..     :...|...:|.:...|.|      :||...:|  |.. |.||.
 Frog  1126 KNCMDIDECERNPLLCRGGECINTEGSFLCNCPNGHELTPSGDACVDINECALS--DNLCRNGKC 1188

  Fly    78 VFLVAFFVCDDNYDFENGISEMFCSNQKWVDEIPTC-IPQLNFEEH--DEKVGYD---LEDYSDE 136
            |.:|..:.|..|..::..:..:.|::   :||   | |.....:.|  :.:..|:   ||.|:  
 Frog  1189 VNIVGTYQCSCNPGYQATLDRLGCTD---IDE---CTIMNGGCDTHCTNSEGSYECSCLEGYA-- 1245

  Fly   137 TVPNDYVENSDIDEDDDEEVSEREPPPPPPPPVVDGADSKPEP-----------------QIVIE 184
            .:| |....:||||.:|.            |.:.||......|                 :..|:
 Frog  1246 LMP-DKRTCTDIDECEDN------------PDICDGGQCTNIPGEYRCLCFDGFMASMDMKTCID 1297

  Fly   185 INDDHANEVV----ESEPAL-------------------------AETETENEVLEN---ETP-- 215
            :|:...|..:    |.|...                         .|.:|.|..|..   ..|  
 Frog  1298 VNECDINSNICMFGECENTKGSFVCHCQVGYAVKKGTTGCTDVDECEIDTHNCHLHATCLNVPGS 1362

  Fly   216 -------------LKAEVQTDVLNSS---NASVKVTNDP--YEPTFLDNNCGEDNGGCAHI--CK 260
                         :|.....:.||.:   :.|....|.|  |..:..:...| |...|:.:  |.
 Frog  1363 FKCTCKEGWIGNGIKCNDLDECLNGTHRCSVSAHCLNTPGSYHCSCAEGYTG-DGFTCSDVDECT 1426

  Fly   261 RLLYPDEN-QPIN-----KCDCREGYTLDPNDYASCLDIDECLESNGGCSEICENLPGEYKCSCQ 319
            ..:...|| |.:|     :|:|..|:| ..:|..||.|||||...|......|.||||.::|.|.
 Frog  1427 ENINLCENGQCLNIPGSYRCECDMGFT-PASDSRSCQDIDECAFQNICVFGTCSNLPGMFRCICN 1490

  Fly   320 EGYYLDESGKSCVDINECANPELSSNC-QGACENLPGSYRCVEP--LEENPEITEVV-------- 373
            |||.||.:|.:|.|::|||:|   .|| .|.|.|.||.|.|..|  .:.||.....|        
 Frog  1491 EGYELDRTGGNCTDVDECADP---INCVNGFCVNTPGRYECNCPPDFQLNPTGVGCVDTRVGNCY 1552

  Fly   374 -------ENPIEKTNEVPVNVSES-------QPAGKTC------NS-----------GFQLSADG 407
                   :..|..:.|:.|.||.|       :..|..|      ||           ||:.:...
 Frog  1553 LNHGARGDGTISCSTEIGVGVSRSSCCCSLGKAWGNPCEICPPVNSSEYNTLCPGGEGFRPNPIT 1617

  Fly   408 TDCQDINEC-EVDGPEDLDNNAVCQ-QKCENTIGSFRCTCVEGYHLLEDQRSCA-LDSCTDLENP 469
            ...:||:|| |:.|        :|| ..|.||.|||:|.|.:||:|.|:.|.|. :|.|  ..:|
 Frog  1618 IILEDIDECQELPG--------LCQGGNCINTFGSFQCECPQGYYLSEETRICEDIDEC--FTHP 1672

  Fly   470 QLNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSCL-VQES----------------------- 510
            .:    |.........|:|.|:||..|......|:|: :::|                       
 Frog  1673 GV----CGPGTCYNTLGNYTCICPSEYMQVNGGHNCMDMRKSFCYRTYNGTTCDNELPFNVTKKM 1733

  Fly   511 ----------------PCST------------------------EKGVEKCS--PGTC---LASE 530
                            ||.|                        ...:::|.  ||.|   :...
 Frog  1734 CCCTYNIGKAWSKPCEPCPTPGTANFKHLCGSIPGFTFDIHTGKAVDIDECKEIPGICTNGVCIN 1798

  Fly   531 DNTSFSCICPTG--YRSEAFSCQDIDECAEDTHLCSHT--CQNTPGGYQCQCPEGLNLVEEYTCL 591
            ...||.|.||||  |......|:|||||:...:.|...  |.|:||.|:|:|..|..|:....|:
 Frog  1799 QIGSFRCECPTGFSYNDLLLVCEDIDECSSGDYFCQRNADCINSPGTYRCECSTGFKLLPNGACI 1863

  Fly   592 AENLC-EVNNNGCEQICLTARGGV-CACREGFRLSADGKSCEDVDEC---LVNNGGCQ------- 644
            ..|.| |:.|......|:...|.. |.|..||::|.|...|.|:|||   ...||.|:       
 Frog  1864 DRNECLEIPNVCSHGTCVDTEGSYHCVCNNGFKVSPDQTMCMDIDECERQPCGNGTCKNTVGSYN 1928

  Fly   645 --------------------------QVCR-----NLPGSYGCICAAGYELLKLDGIRGYCFDID 678
                                      ||||     |..||:.|:|..||||.. ||..  |.||:
 Frog  1929 CLCYPGFEITHNNDCLDIDECSSLYGQVCRNGHCFNEIGSFICLCNEGYELTP-DGKN--CIDIN 1990

  Fly   679 ECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDID 743
            ||......||.. .|:||.||:.|:|||||.:..:|                        |:|||
 Frog  1991 ECVAFPGSCSPG-TCQNLEGSFRCICPPGYEVEREN------------------------CIDID 2030

  Fly   744 ECSLANGNCSHF--CQNEPGGFQCACPLGYALSEDMRTC-------------------------- 780
            || :...|...|  |.|.||.|||.||.|:.|||:.|.|                          
 Frog  2031 EC-IEEPNICLFGACSNTPGSFQCICPPGFVLSENGRRCFDTRQSFCFTRFENGKCSVPKAYNST 2094

  Fly   781 -----------------------------------------------QDIDECLDSNGQCSQ-LC 797
                                                           :|::|||::.|.|:. .|
 Frog  2095 KAKCCCSKMPGEGWGDPCELCPKEGEVAFQDLCPYGHGTIPGIGDTREDVNECLENPGICANGHC 2159

  Fly   798 LNQPGGFACACETGFELTPDGFGCADIDECSQDYGN-CSD-ICINLLGTHACACERGYELAKDKL 860
            :|..|.|.|.|..|:.|...|..|.|.||||  .|| |.: .|.|.:||..|.|:.|:| ....:
 Frog  2160 INTDGSFRCECPMGYNLDYTGVNCVDTDECS--IGNPCGNGTCTNAIGTFECLCDEGFE-PGPMM 2221

  Fly   861 SCLDVDECA--GLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPA---------------- 907
            .|.|::||.  .||   |:..|||..|.:||.||.||||.:|.:.|...                
 Frog  2222 VCEDINECILNPLL---CAFRCINTYGAYECTCPAGYILREDQKMCKDLDECIEGFHDCESRGMV 2283

  Fly   908 ---LVG-----CPPGTQRSADG------------------------------------------- 921
               |:|     ||||..|..||                                           
 Frog  2284 CKNLIGTFMCICPPGMVRRPDGEGCMDENECRTKPGICENGRCVNTIGSYRCDCNEGFQSTPSGT 2348

  Fly   922 ---------------------------------------------C--APIE------------- 926
                                                         |  .|:.             
 Frog  2349 ECLDTRQGFCFSEVLQTMCQMSSSSRNHVTKSECCCNGGRGWGNQCEICPLPGTAQYKKMCPHGP 2413

  Fly   927 ----------------------------------CNPGYT--LGSDDKCVDIDECQKQNGGCSHR 955
                                              ||||||  :|. ..|||:|||.:....|:..
 Frog  2414 GYTTDGKDIDECKVMPNLCRNGQCINNIGSYRCFCNPGYTTDIGG-TACVDLDECSQSPKPCNFI 2477

  Fly   956 CSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFP 1010
            |.|||||::||||.||.|..|.|:|:|:|||...:.:| ...|:|.||||.|:.|
 Frog  2478 CKNTEGSYQCSCPRGYILQEDGKSCKDLDECQTKQHNC-QFLCVNTIGGFTCKCP 2531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342 15/34 (44%)
cEGF 396..415 CDD:289433 7/35 (20%)
FXa_inhibition 425..458 CDD:291342 15/33 (45%)
FXa_inhibition 476..505 CDD:291342 8/28 (29%)
vWFA <550..586 CDD:294047 16/37 (43%)
FXa_inhibition 596..630 CDD:291342 11/35 (31%)
FXa_inhibition 636..>664 CDD:291342 15/68 (22%)
EGF_CA 676..715 CDD:284955 17/38 (45%)
FXa_inhibition 745..780 CDD:291342 17/36 (47%)
FXa_inhibition 786..821 CDD:291342 13/35 (37%)
FXa_inhibition 827..862 CDD:291342 13/36 (36%)
FXa_inhibition 874..904 CDD:291342 14/29 (48%)
FXa_inhibition 945..980 CDD:291342 17/34 (50%)
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
DUF5011 1468..1536 CDD:295940
fbn2XP_002931771.2 EGF_CA 308..348 CDD:284955
TB 365..402 CDD:279073
EGF_CA 507..537 CDD:214542
EGF_CA 547..587 CDD:214542
EGF_CA 589..629 CDD:214542
EGF_CA 630..670 CDD:214542
TB 687..723 CDD:279073
EGF_CA 782..817 CDD:238011
TB 879..911 CDD:279073
TB 984..1019 CDD:279073
Plasmod_Pvs28 1055..1223 CDD:283826 26/104 (25%)
EGF_CA 1087..1121 CDD:214542
EGF_CA 1172..1204 CDD:214542 11/33 (33%)
FXa_inhibition 1218..1253 CDD:291342 9/37 (24%)
EGF_3 1343..1378 CDD:289699 5/34 (15%)
EGF_3 1384..1419 CDD:289699 8/35 (23%)
EGF_CA 1421..1453 CDD:214542 8/31 (26%)
cEGF 1443..1466 CDD:289433 9/23 (39%)
EGF_CA 1463..1497 CDD:238011 17/33 (52%)
EGF_CA 1504..1535 CDD:214542 15/33 (45%)
TB 1565..1600 CDD:279073 9/34 (26%)
EGF_CA 1622..1654 CDD:214542 17/39 (44%)
cEGF 1644..1667 CDD:289433 10/22 (45%)
TB 1721..1757 CDD:279073 3/35 (9%)
EGF_CA 1780..1812 CDD:214542 11/31 (35%)
vWFA <1819..1860 CDD:294047 16/40 (40%)
vWFA <1855..1901 CDD:294047 13/45 (29%)
EGF_CA 1906..1940 CDD:214542 7/33 (21%)
vWFA <1940..1985 CDD:294047 15/45 (33%)
cEGF 1968..1991 CDD:289433 12/25 (48%)
EGF_CA 1988..2020 CDD:214542 16/32 (50%)
EGF_CA 2028..2068 CDD:214542 21/40 (53%)
TB 2085..2122 CDD:279073 0/36 (0%)
EGF_CA 2143..2184 CDD:214542 15/40 (38%)
EGF_CA 2185..2219 CDD:214542 16/36 (44%)
EGF_CA 2310..2350 CDD:304395 0/39 (0%)
TB 2369..2404 CDD:279073 2/34 (6%)
EGF_CA 2421..2454 CDD:214542 5/32 (16%)
vWFA <2461..2501 CDD:294047 21/39 (54%)
vWFA <2499..2535 CDD:294047 15/34 (44%)
vWFA <2541..2577 CDD:294047
cEGF 2566..2589 CDD:289433
EGF_CA 2586..>2615 CDD:214542
EGF_CA 2626..2657 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 48 1.000 Domainoid score I11717
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4721at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm47507
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1431
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.010

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