DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and svep1

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:XP_012808841.2 Gene:svep1 / 100493788 XenbaseID:XB-GENE-5996067 Length:3695 Species:Xenopus tropicalis


Alignment Length:1929 Identity:390/1929 - (20%)
Similarity:596/1929 - (30%) Gaps:747/1929 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 VLCALAC-VAFASASPSSERKRKNVM-----NIPEDPKVSDSLAASLDMSCSSAKILPPEINHGR 65
            |.|.|.| ..:|.|..|::    |:.     .:.:.||.:|....||:...          |||.
 Frog   741 VNCTLVCKEGYALAEGSTQ----NLYCAFRDGLWKPPKRADWPDCSLNRFA----------NHGF 791

  Fly    66 VSVFDRRRRGKKVFLVAFFVCDDNY-------DFENGISEM---FCSNQKWVDEIPTCIPQLNFE 120
            .| |:...:..:        ||||.       .|::.:.:|   ||::   .|:| .|..:..::
 Frog   792 KS-FEMLYKATR--------CDDNSLLKNFADAFQSSLGKMVPSFCTD---ADDI-ECRLEDQYQ 843

  Fly   121 EHDEKVGYDLE----------------DYS-DETVPNDYVENSDIDEDDDEEVSEREPPPPPPPP 168
            ....:..||.|                ||| ||    |:.   |..|.:|.|....:.|...|..
 Frog   844 RQCLEYNYDYENGFAIGPAGWGAANKLDYSYDE----DFF---DATETEDAEKPLSDSPHTAPLR 901

  Fly   169 V-------VDGADSK-----------PEPQIVIEINDDHANEVVESE---PALAETETENEVLEN 212
            |       ...||.|           |.|:        ..|:.:|.|   ..|...||    |.|
 Frog   902 VKRHRRLNAGAADQKVKFIFNITASVPLPK--------QRNDTLEQENQQRLLLTLET----LTN 954

  Fly   213 ETPLKAEVQTDVLNSSNASVKVTNDPYEPTFLDNNCGEDNGGCAHICKRLLYPDENQPINKCDCR 277
            .  ||..::.:.|:|.:.|       .|....|:|..||.       |..|:           ||
 Frog   955 R--LKRILRKEPLHSFHFS-------SEMIIADSNSLEDG-------KAFLF-----------CR 992

  Fly   278 EGYTLDPNDYASCLDIDECLESNGGCSEICENLP-GEY------KC-SCQEGYYLDESG----KS 330
            .|..|.                    ..:|.|.| |.|      .| ||..|.|.||.|    ||
 Frog   993 PGSVLK--------------------GRMCVNCPKGTYYSLEHRACESCWTGSYQDEEGQMDCKS 1037

  Fly   331 CV--DINECANPELSSNCQGACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSE---S 390
            |.  ...|..:.:..|.|:..|:  ||:|.               .|.:|.....|....:   .
 Frog  1038 CPAGTYTEYLHSKRISECKAQCK--PGTYS---------------SNGLETCESCPHGTYQPVFG 1085

  Fly   391 QPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRC-TCVEGYHLLED 454
            ..|.:.|.:|......|:  .|.:||.|.          |.....:..|...| .|...|:..|.
 Frog  1086 SKACEVCPNGMSTVKRGS--VDKSECGVP----------CHAGEFSRTGLVPCYPCPRDYYQPEP 1138

  Fly   455 QRSCALDSCTDLENPQLNRTRCAHECQDL-------PEGSYRCVCPKG----YELSEDQ-HSCLV 507
            .:|..| ||.......::..|...:|...       .|.....:.|:.    |::|... :.||:
 Frog  1139 GKSYCL-SCPFYGTTTISGARSIADCSSFGSSFSAAEESVMIPISPENVNSKYKVSSQVFNECLL 1202

  Fly   508 QESPCSTEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQ-DIDECAEDTHLCSHTCQNTP 571
              :||.        :.|||  ::..:.:.|.|..||...  .|: :|:||:......:..|.:..
 Frog  1203 --NPCQ--------NSGTC--TQIGSGYICSCIKGYTGA--KCENEINECSSIPCRNNGICIDRV 1253

  Fly   572 GGYQCQCPEGLNLVEEYTCLAENLCEVNNNGC--EQICLTARGGV----CACREGFRLSADGKSC 630
            |.:.|||..|.:    .|...||:.|.::|.|  |.||:   .|:    |.|..||.    |..|
 Frog  1254 GEFDCQCLSGFS----GTLCEENINECSSNPCLNEAICI---DGINAFYCRCANGFL----GPRC 1307

  Fly   631 E-DVDECL----VNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQ 690
            | ::||||    :|||    ||.:|...:.|:|.|||.....:.      |||||  .:..|.:.
 Frog  1308 EIEIDECLSRPCLNNG----VCDDLKAGFQCLCPAGYTGKVCEK------DIDEC--LSGPCKNG 1360

  Fly   691 MLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNCSHF 755
            ..|.:...|:.|.||.|:     ...|..:|   :.|..|:...:..||:|        |..|:.
 Frog  1361 ASCTDGINSFRCQCPEGF-----TGQVCEIN---VDDCVSNPCLNNATCVD--------GLNSYI 1409

  Fly   756 CQNEPG--GFQC---------------------------------AC--------------PLGY 771
            |:.:||  |.:|                                 .|              |:.|
 Frog  1410 CKCQPGYSGIRCETEQPFGFNLDFEVSGIYGYVLLDNVMPTLSAITCAFWMRSSDTTNYGTPISY 1474

  Fly   772 AL----------------------SEDMRTCQDIDEC-------------------LD----SNG 791
            ||                      .|.:..|..:::.                   :|    ..|
 Frog  1475 ALDNGSDNAFLLTDYNGWVLYINGKEKITDCPSVNDAKWHHIAVTWTNTDGSWKVYIDGKQSDGG 1539

  Fly   792 QCSQLCLNQPGGFACACETGFELTPDGFGCAD--IDECSQ----DY------------------- 831
            :...:..:.|||.|.......:...:||..|:  :...||    |:                   
 Frog  1540 KGLSVGESIPGGGALVLAQEQDQRGEGFNPAESFVGSLSQLNIWDHPLTPAQIKSLAISCPVELQ 1604

  Fly   832 -GN-----------------------CSDICINLLGT----HACA------------CERGYELA 856
             ||                       |:| |..|.||    ||..            |..|:::.
 Frog  1605 KGNVLAWADFLPGVVGRVKVDHKSKFCAD-CPALEGTSPHLHATKSDHKPGSKISLFCNPGFQIV 1668

  Fly   857 KDKLSCLDVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRS--- 918
                             |....:|:|..   |...||.:        |.....|.||..:..   
 Frog  1669 -----------------GKPERQCLNLG---EWDQPLPH--------CERISCGKPPRLENGFYN 1705

  Fly   919 -----ADGCAPIECNPGYTLGSDDK---------------CVDIDECQKQNGGCSH-RCSNTEGS 962
                 |......:||.||.|..|.:               |:|:|||:..:....| .|.||.||
 Frog  1706 AEDLFAGSTVTYQCNIGYYLLGDSRMFCTDNGSWNGISPSCLDVDECEIGSDCDEHASCMNTNGS 1770

  Fly   963 FKCSCPPGYELDSDQKTCQDIDEC-------------------DQDKTSCITG---------TCI 999
            :.|:|.|.|.  .|.|.|.:..:|                   .|...||..|         ||:
 Frog  1771 YICTCIPPYH--GDGKKCLEPVKCKDPGEIENGNYSGNHFGVGSQLMFSCHEGYDLIGLVKVTCL 1833

  Fly  1000 -----------------------------------NEIGGFRCEFPKFPVLPEIPT--------A 1021
                                               .||..|||. ..:.::....|        :
 Frog  1834 ESGEWDDALPYCQAVSCGKVPAPNNGEILGSNFTFGEIVTFRCN-EGYTLIGNEETVCLANRSWS 1897

  Fly  1022 SSLPESPKIELKTPKYPDFTELSNEIPENPKKPAEFDYPEPKFPSLPKW---EGLPKLPPLADIP 1083
            .:||....:....||     |:.|.|         |......|.|...:   .|.          
 Frog  1898 HALPTCESVTCSKPK-----EIENGI---------FSLSGLTFNSTASYACKTGY---------- 1938

  Fly  1084 TSKAPVPLRPEVPKSLWVNQLQPRDL--CPRFQAPRNGKSHCNRYRHKQKLFYYSRCRISCNSGY 1146
            :.:.|..|..|...: |.:::...||  |......|:..:..:.|.:...:.|      .|..||
 Frog  1939 SLQGPATLICEASGN-WSSEVPSCDLVSCGPPPLVRDADATGDNYTYSNIITY------KCKEGY 1996

  Fly  1147 ILQGPEIKSCDANGIWEGPETKCVAINQPRAQSPGICPALKPAQNGVILPASCTQGPS------- 1204
            .|.||:..:|.::|.|.....:|:|:                         ||.:.|:       
 Frog  1997 TLVGPDTINCSSSGKWSEHIPQCMAV-------------------------SCDEPPNVDYASSH 2036

  Fly  1205 ----RFGDVCRLQCNAGFVSTGSLLTACMMLQGWSFGADLNCQPFGNGL------LGNQLSPMWN 1259
                .|||.....|:.|:    |::....||          |...||.:      :.|.::....
 Frog  2037 SSHRLFGDTAYYYCSDGY----SMVDNAQML----------CNTEGNWVPPDGKEIPNCIADFCE 2087

  Fly  1260 SPKTVTPHQIQNVEQIRPYIN-------CPENVVILLHA------GEQ--KAHVTLQ-------R 1302
            .|.:|....:::|.:.: :::       |.|..|:...|      |.|  .:.:|:|       .
 Frog  2088 RPSSVAHSILESVNKAK-FVSGSTVSFKCMEGFVLNTTARIECVRGGQWIPSSLTIQCIPVRCGE 2151

  Fly  1303 PQ---------TNVKNGRLVAHPA-------------------WAGQLQGHLPAGVHKVDFRVND 1339
            |.         ||...|.:||:..                   |:|:|....|..       .:|
 Frog  2152 PPSIKNGYVSGTNYSFGSVVAYSCDKGYYIKGEKKRTCLASGEWSGRLPACHPGS-------CDD 2209

  Fly  1340 PETKLT---IKCHTIITVKAATPRESNP-FTL----FRISDYSRSSLPRPAPFATLSTGSSFSFP 1396
            | .||.   :|..|.:..::......|| :.|    .|:...:|.......|...|.|...    
 Frog  2210 P-PKLENGFVKSKTGLLYESKVIYACNPGYKLVGSNVRVCQLNRHWYSESPPTCVLLTCEK---- 2269

  Fly  1397 AFKALDATPKPVSFTKFQVFPDSESSEHSKLGSSSFFRLEPLFHESSKLISAAPASSENTRVDLG 1461
                    |.||.:       .|...|:.::||...|..|..:..|..|......:.|..:....
 Frog  2270 --------PPPVKY-------GSMKGENFEVGSKVEFFCEDGYELSGDLSWTCQKNGEWDKKQTP 2319

  Fly  1462 SDTSNYC--PPSIE--VYLKENQNLRSVVWDEPRF---EGKLLK 1498
            :...:.|  ||..|  :.|||..|...:|    ||   ||.:|:
 Frog  2320 TCMPSKCQDPPLYENHLVLKEVPNEVGIV----RFSCKEGHVLE 2359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342 14/46 (30%)
cEGF 396..415 CDD:289433 4/18 (22%)
FXa_inhibition 425..458 CDD:291342 6/33 (18%)
FXa_inhibition 476..505 CDD:291342 5/40 (13%)
vWFA <550..586 CDD:294047 10/36 (28%)
FXa_inhibition 596..630 CDD:291342 12/39 (31%)
FXa_inhibition 636..>664 CDD:291342 13/31 (42%)
EGF_CA 676..715 CDD:284955 12/38 (32%)
FXa_inhibition 745..780 CDD:291342 13/105 (12%)
FXa_inhibition 786..821 CDD:291342 8/57 (14%)
FXa_inhibition 827..862 CDD:291342 15/97 (15%)
FXa_inhibition 874..904 CDD:291342 6/29 (21%)
FXa_inhibition 945..980 CDD:291342 13/35 (37%)
CCP 1110..1170 CDD:153056 13/59 (22%)
CCP 1183..1235 CDD:153056 11/62 (18%)
DUF5011 1468..1536 CDD:295940 14/38 (37%)
svep1XP_012808841.2 vWFA_subfamily_ECM 74..236 CDD:238727
Ephrin_rec_like 302..352 CDD:311571
PHA02927 <365..550 CDD:222943
CCP 430..486 CDD:153056
HYR 552..634 CDD:367105
DUF5011 646..716 CDD:383419
Ephrin_rec_like 1008..1055 CDD:311571 15/46 (33%)
Ephrin_rec_like 1062..1109 CDD:311571 10/63 (16%)
Ephrin_rec_like 1116..1163 CDD:311571 10/47 (21%)
EGF_CA 1198..1232 CDD:238011 11/47 (23%)
EGF_CA 1235..1270 CDD:238011 10/38 (26%)
EGF_CA 1272..1308 CDD:238011 13/42 (31%)
EGF_CA 1311..1346 CDD:238011 15/38 (39%)
EGF_CA 1348..1384 CDD:238011 13/42 (31%)
EGF_CA 1386..1422 CDD:238011 12/46 (26%)
LamG 1422..1625 CDD:389952 21/202 (10%)
Sushi 1631..1688 CDD:365861 16/85 (19%)
CCP 1693..1746 CDD:214478 10/52 (19%)
EGF_CA 1748..1786 CDD:214542 16/39 (41%)
PHA02927 <1791..1961 CDD:222943 28/195 (14%)
PHA02639 1904..>2082 CDD:165022 45/247 (18%)
PHA02927 2081..2322 CDD:222943 47/268 (18%)
PHA02817 2321..>2439 CDD:165167 14/43 (33%)
PHA02927 2404..2612 CDD:222943
PHA02927 2518..2773 CDD:222943
CCP 2777..2830 CDD:214478
PHA02927 2830..3061 CDD:222943
CCP 3066..3119 CDD:214478
PHA02927 3119..3355 CDD:222943
PHA02927 3257..3470 CDD:222943
PHA02927 3366..3586 CDD:222943
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.