DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and fbn1

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_002936615.3	Gene:	fbn1 / 100490545	XenbaseID:	XB-GENE-954190	Length:	2866	Species:	Xenopus tropicalis

Alignment Length:	1284	Identity:	361/1284 - (28%)
Similarity:	474/1284 - (36%)	Gaps:	435/1284 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 KCDCREGYTLDPNDYASCLDIDECLESNGGCSE-ICENLPGEYKCSCQEGYYLDESG----KSCV 332
            ||.|..|:.||..: .:|.|||||..|...|.: .|.|.||:::|.|.|||   |||    |:|:
Frog  1051 KCRCDNGFALDAEE-RNCTDIDECRISPDVCGQGNCVNTPGDFECDCFEGY---ESGFMMMKNCM 1111

  Fly   333 DINEC-ANPELSSNCQGA-CENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSESQPA-- 393
            ||:|| .||.|   |:|. |.|..||::|     |.|...||..:     |...::::|.:.:
Frog  1112 DIDECERNPLL---CRGGICLNTEGSFKC-----ECPPGHEVAPD-----NSACIDINECELSTD 1163

  Fly   394 -----------GK---TCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRCT 444
                       |:   .|..|:||:.|...|.|.|||:.       .|..|...|.|:.||:.|.
Frog  1164 LCRHGRCINLIGRYQCACEPGYQLTPDKLSCVDTNECDF-------FNGGCDTFCTNSEGSYECH 1221

  Fly   445 CVEGYHLLEDQRSCALDSCTDLENPQLNRTRC-AHECQDLPEGSYRCVCPKGYELSEDQHSCL-V 507
            |.:|:.|:.|.|     ||||::..:.|...| ..:|.::| |.|||:|.:||..|:|..:|| |
Frog  1222 CRDGFALMPDHR-----SCTDIDECETNPNICDGGQCTNIP-GEYRCLCFEGYMASDDMKTCLDV 1280

  Fly   508 QE----------SPCSTEKG--VEKCSPG---------------------------TCLASEDNT 533
            .|          ..|...||  :..|.||                           ||    .||
Frog  1281 DECELHLNICLSGSCENTKGSFICHCDPGYSGKKGQTGCTDINECEIGAHNCDRHATC----TNT 1341

  Fly   534 --SFSCICPTGYRSEAFSCQDIDECAEDTHLCSHT--CQNTPGGYQCQCPEGLNLVEEYTCLAEN 594
              ||.|.|..|:......|.|:|||:..|||||..  |:||.|.|:|.|.||. :.:.:||...:
Frog  1342 PGSFKCSCSPGWVGNGIKCSDLDECSNGTHLCSPNADCKNTMGSYRCLCKEGY-VGDGFTCTDVD 1405

  Fly   595 LCEVNNNGC-EQICLTARGGV-CACREGFRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCI 657
            .|..|.|.| ...||...||. |.|..||..|.|||:|||:|||.:.|......||||||.:.|.
Frog  1406 ECSENLNLCGNGQCLNTPGGYRCDCDMGFLPSVDGKACEDIDECTLPNICVFGTCRNLPGLFRCD 1470

  Fly   658 CAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGL---------- 712
            |..|||   ||...|.|.|:||||:.|...|.  .|:|..|||||.|||.:.|..
Frog  1471 CDTGYE---LDRTGGNCTDVDECSEPTMCISG--TCQNTPGSYTCECPPDFELNPTRVGCVDTRS 1530

  Fly   713 -----------DNHIVTSLNSSFITDSTSSETPSAHTCL-------------------------- 740
                       ||..|:..|...::      .|.|..|.
Frog  1531 GTCYLDVKPRGDNGDVSCSNEIGVS------VPKASCCCSLGKAWGTPCELCPAVNSSEYKVLCP 1589

  Fly   741 ---------------DIDECSLANGNC-SHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDS 789
                           |||||....|.| ...|.|..|.|||.||.||.|:|:.|.|.|::|| |.
Frog  1590 GGEGFRPNPITVILEDIDECLELPGLCQGGKCINTFGSFQCRCPPGYYLNEETRVCDDVNEC-DQ 1653

  Fly   790 NGQCSQ-LCLNQPGGFACACETGFELTPDGFGC-------------------------------- 821
            .|.|.. .|.|..|.:.|.|...:.....|..|
Frog  1654 PGICGPGTCFNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCFRNYYAENQTCDGELLYNMTKKMC 1718

  Fly   822 ---------------------------------------------ADIDECSQDYGNCSD-ICIN 840
                                                         .|||||.:..|.|.: :|||
Frog  1719 CCSYNIGRAWHRPCEECPLPSTDEFASLCGSARPGFLIDIYTGLPVDIDECREIPGVCENGVCIN 1783

  Fly   841 LLGTHACACERGYELAKDKLSCLDVDECAG--------------------------LLSGG---- 875
            ::|:..|.|..|:......|.|.|:|||..                          ..|.|
Frog  1784 MVGSFRCECPMGFFYNDKLLICEDIDECQNGPVCQRNADCVNTPGSYRCDCKPGYKFTSTGQCVD 1848

  Fly   876 ----------CSH-ECINKAGTFECGCPLGYILNDDGRSC--------SPALVGCPPGTQRSADG 921
                      ||| ||.:..|.:.|.|..|:..|:|...|        .|    |..||.::..|
Frog  1849 RNECQEIPNICSHGECTDTTGGYYCVCHNGFKTNEDQTMCLDINECERDP----CGNGTCKNTIG 1909

  Fly   922 CAPIECNPGYTLGSDDKCVDIDECQKQNGG-CSH-RCSNTEGSFKCSCPPGYELDSDQKTCQDID 984
            .....|..|:.|..::.|:|||||...||. |.: :|:||.|||.|.|..|||..||::||.||:
Frog  1910 SYNCRCFDGFILSHNNDCIDIDECTTLNGQLCRNGQCNNTVGSFVCLCNEGYEKASDERTCLDIN 1974

  Fly   985 ECDQDKTSCITGTCINEIGGFRCEFPKFPVL--------------PEI---PTASSLPESPKIEL 1032
            ||..|...|..|||.|..|.:||..|...||              |||   .|.|::|.|
Frog  1975 ECALDPGKCAPGTCQNLDGAYRCICPPGYVLEGDTCKDIDECVEEPEICALGTCSNVPGS----- 2034

  Fly  1033 KTPKYPDFTELSNE---IPENPKKPAEF------------DYPEPKFPSLPKWE----------G 1072
                   ||.|..|   :....|:..:.            ....||..:..|.|          |
Frog  2035 -------FTCLCPEGFVLSSTGKRCQDLRVSFCFTKFEDGQCTSPKARNHSKQECCCALNGAGWG 2092

  Fly  1073 LP-KLPP------LADIPTSKAPVPLRPEVPKSLWVNQLQPRDLCPRFQAPRNGKSHCNRYRHKQ 1130
            .| :|.|      |..|......|.:.|:..:......:.| |.|...|......|:
Frog  2093 TPCELCPVDGDAALQQICPFGMGVIVGPDDERVDMDECIDP-DKCKNGQCINTDGSY-------- 2148

  Fly  1131 KLFYYSRCRISCNSGYILQGPE---IKSCDA---------------------NGIWEGPETKCVA 1171
                  ||  .|:.||:|...|   |..|..                     .|...||...|..
Frog  2149 ------RC--ECSFGYVLSVDECIDIDECSVGNPCGNGTCKNIIGGFECTCEEGFEPGPMMSCED 2205

  Fly  1172 INQPRAQSPGICPALKPAQNGVILPASCTQGPSRFGDV-CRLQCNAGFV 1219
            :|:        |     |||.::....|.   :.:|.. |:  |.||:|
Frog  2206 VNE--------C-----AQNPLLCAFRCV---NTYGSYECK--CPAGYV 2236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	16/39 (41%)
		cEGF	396..415	CDD:289433	7/18 (39%)
		FXa_inhibition	425..458	CDD:291342	12/32 (38%)
		FXa_inhibition	476..505	CDD:291342	12/29 (41%)
		vWFA	<550..586	CDD:294047	19/37 (51%)
		FXa_inhibition	596..630	CDD:291342	16/35 (46%)
		FXa_inhibition	636..>664	CDD:291342	12/27 (44%)
		EGF_CA	676..715	CDD:284955	19/59 (32%)
		FXa_inhibition	745..780	CDD:291342	16/35 (46%)
		FXa_inhibition	786..821	CDD:291342	10/35 (29%)
		FXa_inhibition	827..862	CDD:291342	11/35 (31%)
		FXa_inhibition	874..904	CDD:291342	12/44 (27%)
		FXa_inhibition	945..980	CDD:291342	17/36 (47%)
		CCP	1110..1170	CDD:153056	15/83 (18%)
		CCP	1183..1235	CDD:153056	11/38 (29%)
		DUF5011	1468..1536	CDD:295940
fbn1	XP_002936615.3	Fibrillin_U_N	46..87	CDD:408021
		TB	200..>233	CDD:395554
		EGF_CA	251..283	CDD:214542
		EGF_CA	293..333	CDD:419698
		TB	350..394	CDD:395554
		EGF_CA	490..521	CDD:214542
		EGF_CA	530..571	CDD:214542
		EGF_CA	572..604	CDD:238011
		cEGF	593..616	CDD:403760
		EGF_CA	613..646	CDD:214542
		TB	670..711	CDD:395554
		EGF_CA	765..806	CDD:238011
		EGF_CA	807..841	CDD:214542
		TB	862..>894	CDD:395554
		TB	967..1008	CDD:395554
		EGF_CA	1069..1103	CDD:214542	17/36 (47%)
		EGF_CA	1112..1144	CDD:214542	16/39 (41%)
		EGF_CA	1154..1186	CDD:214542	4/31 (13%)
		FXa_inhibition	1204..1235	CDD:405372	12/35 (34%)
		EGF_CA	1279..1313	CDD:238011	8/33 (24%)
		EGF_3	1325..1360	CDD:403986	9/38 (24%)
		EGF_3	1366..1401	CDD:403986	15/35 (43%)
		EGF_CA	1403..1444	CDD:214542	16/40 (40%)
		EGF_CA	1445..1480	CDD:214542	18/37 (49%)
		EGF_CA	1486..1517	CDD:214542	17/32 (53%)
		TB	1548..1589	CDD:395554	4/46 (9%)
		EGF_CA	1605..1637	CDD:214542	16/31 (52%)
		EGF_CA	1647..1686	CDD:214542	12/39 (31%)
		TB	1705..1748	CDD:395554	0/42 (0%)
		EGF_CA	1765..>1796	CDD:214542	13/30 (43%)
		EGF_CA	1807..>1838	CDD:214542	4/30 (13%)
		vWFA	<1846..1885	CDD:412136	10/38 (26%)
		EGF_CA	1890..1924	CDD:214542	8/37 (22%)
		EGF_CA	1929..1962	CDD:214542	17/32 (53%)
		TB	2069..2111	CDD:395554	10/41 (24%)
		EGF_CA	2126..>2156	CDD:214542	8/46 (17%)
		EGF_CA	2165..2199	CDD:214542	3/33 (9%)
		vWFA	<2203..2242	CDD:412136	13/52 (25%)
		EGF_CA	2290..>2320	CDD:214542
		TB	2356..2389	CDD:395554
		EGF_CA	2400..2441	CDD:214542
		vWFA	<2440..2480	CDD:412136
		cEGF	2463..2486	CDD:403760
		EGF_CA	2483..>2514	CDD:311536
		EGF_CA	2522..2564	CDD:214542
		EGF_CA	2565..>2594	CDD:214542
		EGF_CA	2605..2636	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11717
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47507
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010