Protein Alignment frac and fbln2

DIOPT Version :9

• Sequence 1: NP_001137905.1
• Gene: frac / 38850
• FlyBaseID: FBgn0035798
• Length: 1618
• Species: Drosophila melanogaster
• Sequence 2: XP_017949170.2
• Gene: fbln2 / 100487324
• XenbaseID: XB-GENE-959371
• Length: 1029
• Species: Xenopus tropicalis
• Alignment Length: 977
• Identity: 234/977 - (23%)
• Similarity: 343/977 - (35%)
• Gaps: 344/977 - (35%)

  Fly   168 PVVDGADSKPEPQIVIEINDDH-ANEVVESEPALAETETENEVLENETPLKAEVQT-DVLNSSNA 230
            |::|..||.||.|.....:.:| |.|:  :.||......:...|::.:.|..:... |.|||||.
 Frog   186 PLMDTPDSDPERQYDYPYSQEHEATEL--ANPAEKNNNYKRNALQDHSLLDYDDGLGDSLNSSNT 248

  Fly   231 SVKVTNDPYEPTFLDNNCGEDNGGCAHICKRLLYPDENQP-INKCDCREGYTLDPNDYASCLDID 294
            .|...|   |..|..::             ..::|...|. :|.......|...|.:..:.....
 Frog   249 KVYPFN---EVDFTTSS-------------YKIHPTSVQKGLNATSMANAYRTKPTNTIAITTTP 297

  Fly   295 ECLESNGGCSEICENLPGEYKCSCQEGYYLDESGKSCVDINECANPELS--------SNCQGACE 351
            ...:|.                       |:|:....:.::....||:.        ||.
 Frog   298 TYNDSR-----------------------LEETTAQQITLHPHIEPEVMGLKDPFKFSNV----- 334

  Fly   352 NLPGSYR--------------CVEPL--EENPEITEVVENPIEKTNEVPV--------------- 385
             ||.|.:              .:.|:  .|:||  :..|.|:.:.|.:|.
 Frog   335 -LPTSSKGDLKTDFQTTTAPHTMSPMSRHESPE--DKREEPVTQLNSIPTVAPTPQQQENSQQMT 396

  Fly   386 ---------------------NVSESQPAGKT-------CNSGFQLSADGTDCQDI-----NECE 417
                                 |:|.... |.|       |.:|.|.|.|..:|:::     .||.
 Frog   397 TESSTTLPHYIEERYDPSHIYNISRLHD-GSTKDLVETCCAAGQQWSIDHGECENMPLSASEECR 460

  Fly   418 VDGPEDLDNNAVCQQKC------ENTIGSFRCTCVEGYHLLEDQRSCALDSCTDLENPQLNRTRC 476
                       :.:::|      ||       ||:.|....::.     ..|...||
 Frog   461 -----------LAEKQCCISYIKEN-------TCIAGMIAAKED-----GICLPAEN-------- 494

  Fly   477 AHECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNTSFSC---- 537
                 |:.|.||..:|            |    ..||.  |::....|:...|..|..:.|
 Frog   495 -----DICERSYFKLC------------C----DCCSW--GLKVRKEGSSCESNLNLGYPCNHMM 536

  Fly   538 -ICPTGYRS------------------EAFSCQDIDECAEDTHLCSHTCQNTPGGYQCQCPEGLN 583
             :|..|...                  ||    |||||..:||.|..       |.:|     :|
 Frog   537 ILCCNGEEQLIPPDAKIPSKPELLVLPEA----DIDECVLNTHTCIQ-------GERC-----VN 585

  Fly   584 LVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRLSADGKSCEDVDECLVNNGGCQ--QV 646
            .|..:.|:.|..||                     .||.: .:| :|.|:|||::|...|.  :.
 Frog   586 TVGSFICIQEERCE---------------------SGFTV-VNG-ACTDIDECVINRHTCATGER 627

  Fly   647 CRNLPGSYGCI----CAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTC----- 702
            |.|..|||.||    |..||.|  :||:   |.||:||:.....|.....|.|..||:.|
 Frog   628 CVNTVGSYICIQERRCEIGYTL--VDGV---CTDINECASLAAPCKQGFTCVNTLGSFVCQRKQL 687

  Fly   703 LCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNCS--HFCQNEPGGFQC 765
            .|..||                  :|..:.|    .|:|||||.|...|||  ..|.|.||..:|
 Frog   688 KCNKGY------------------ESDENGT----ICIDIDECKLGTHNCSQEQSCFNLPGSHRC 730

  Fly   766 ACPLGYALSEDMRTCQDIDECLDSNGQ-CSQLCLNQPGGFACACETGFELTPDGFGCADIDECSQ 829
            .|.:||......:.|.|::||....|: |...|.|..|.:.|:|..||:|..||..|.|::||..
 Frog   731 DCKIGYRYDLFRKACLDVNECWIYPGRLCHHTCENTVGSYKCSCFAGFQLGQDGKQCEDVNECKS 795

  Fly   830 DYGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCSHECINKAGTFECGCP-L 893
            :  .|:..|.|:.|::.|.|:.||:||.|.:||.|:|||.......|...|:|..|:::|.|| .
 Frog   796 N--PCNQECTNVYGSYQCYCKEGYKLADDGISCEDIDECVQNFGSLCVFACVNTPGSYQCACPET 858

  Fly   894 GYILNDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDECQKQNGGC--SHRC 956
            ||.|:.:||:|.                                   |||||:.....|  |..|
 Frog   859 GYTLSVNGRTCK-----------------------------------DIDECEVGTHNCSSSEEC 888

  Fly   957 SNTEGSFKC---SCPPGYELDS----DQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFPKFPV 1014
            .|.:||:||   :||..|...|    ::.:|.:..||.....         .|...|..||...|
 Frog   889 YNIQGSYKCLSYTCPENYRKVSNMVCERISCFNYQECQNSPV---------RISYLRLTFPAGVV 944

  Fly  1015 LP 1016
            :|
 Frog   945 VP 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	3/34 (9%)
		cEGF	396..415	CDD:289433	7/30 (23%)
		FXa_inhibition	425..458	CDD:291342	6/38 (16%)
		FXa_inhibition	476..505	CDD:291342	5/28 (18%)
		vWFA	<550..586	CDD:294047	11/35 (31%)
		FXa_inhibition	596..630	CDD:291342	5/33 (15%)
		FXa_inhibition	636..>664	CDD:291342	13/33 (39%)
		EGF_CA	676..715	CDD:284955	13/43 (30%)
		FXa_inhibition	745..780	CDD:291342	13/36 (36%)
		FXa_inhibition	786..821	CDD:291342	13/35 (37%)
		FXa_inhibition	827..862	CDD:291342	12/34 (35%)
		FXa_inhibition	874..904	CDD:291342	12/30 (40%)
		FXa_inhibition	945..980	CDD:291342	13/43 (30%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
fbln2	XP_017949170.2	ANATO	503..546	CDD:412122	11/60 (18%)
		EGF_CA	566..603	CDD:214542	17/69 (25%)
		EGF_CA	611..648	CDD:214542	15/36 (42%)
		EGF_CA	656..698	CDD:214542	14/59 (24%)
		EGF_CA	704..745	CDD:311536	17/40 (43%)
		cEGF	769..792	CDD:403760	9/22 (41%)
		cEGF	808..831	CDD:403760	10/22 (45%)
		cEGF	850..874	CDD:403760	11/58 (19%)
		EGF_CA	871..>907	CDD:311536	15/35 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940