DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and thbd

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_012818722.2	Gene:	thbd / 100485229	XenbaseID:	XB-GENE-967380	Length:	541	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	140/523 - (26%)
Similarity:	200/523 - (38%)	Gaps:	132/523 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   527 LASEDNTSFSCI---CPTG-YRSEAFSCQDIDECAEDTHLCSHTCQNTPGGYQCQCPE-GLNLVE 586
            ||.::.|:|:||   |..| :.|:.:      :.||.                 ||.| |.||:.
Frog    22 LADQNLTNFTCIGQSCYLGVWNSKRY------KKAER-----------------QCTELGGNLMA 63

  Fly   587 EYTCLAENLCEV-----------------NNNGCEQICLTARGGVCACREGFRLSADGKSCEDVD 634
            ..:.:...:.|:                 ....|..|.|..||......|.....::.||.|
Frog    64 VRSSVEAEVIEMLMGKLGDKVASVWIGLELRGQCTDISLPLRGFQWVTGESNTNYSNWKSNE--- 125

  Fly   635 ECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGS 699
                      :.|.||       |...::.|.        ::...|..:|.|    .|||.   .
Frog   126 ----------RKCGNL-------CVVVHKDLS--------WEEAVCDSKTDG----YLCEI---P 158

  Fly   700 YTCLCPPGY-ALGLDNHIVTSLNS-----SFITDSTSSETPSAHTCLDIDE-------------- 744
            |:..|.|.| ..|||....|.|..     :|:...|.:..||||..|..::
Frog   159 YSASCQPIYFPQGLDVTYETPLGMAGPGITFLPPGTKAVIPSAHLSLVCEDQGDGEMKWTSEDYG 223

  Fly   745 ---CSLANGNCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCLNQPGGFAC 806
               |.:.||.||..|..:..|.:|.|.....||:|.|:|..:...|.        |:.......|
Frog   224 AWNCMIENGGCSFICNGDTEGSRCECGPNTNLSDDGRSCMPLPSSLQ--------CIPDQSTGTC 280

  Fly   807 ACETGFELTPDGFGCADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECAGL 871
            .|..||.|..||..|.|||:||.....|..:|.|..|:..|.|..|:.:. |.| |.|::|| .:
Frog   281 VCAEGFALAEDGMTCQDIDDCSLIPDLCDQVCTNTDGSFMCTCLPGFVMV-DGL-CEDINEC-DI 342

  Fly   872 LSGGCSHECINKAGTFECGCPLGYILNDDGRS-----CSPALVGCPP-GTQRSADGCAPIECNPG 930
            .:..|.::|.|..|.|.|.|..|||:::...|     |:...  ||. ......|.|   .|..|
Frog   343 PTTICEYDCENFPGGFSCVCGEGYIIDEKNPSRCKQFCNTTT--CPAFCNDNFVDQC---NCPDG 402

  Fly   931 YTLGSDDK----CVDIDECQKQNGGCSHRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKT 991
            |.|.:|::    |.|||||  :||.|...|.|..||:.|.||.|:.|:.| .:|...:...:|.|
Frog   403 YVLDTDEELKFVCRDIDEC--ENGFCKDLCHNLPGSYACYCPEGFILEKD-NSCTPAEGSGEDLT 464

  Fly   992 SCI 994
            :.|
Frog   465 TSI 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342
		cEGF	396..415	CDD:289433
		FXa_inhibition	425..458	CDD:291342
		FXa_inhibition	476..505	CDD:291342
		vWFA	<550..586	CDD:294047	8/36 (22%)
		FXa_inhibition	596..630	CDD:291342	8/50 (16%)
		FXa_inhibition	636..>664	CDD:291342	4/27 (15%)
		EGF_CA	676..715	CDD:284955	13/39 (33%)
		FXa_inhibition	745..780	CDD:291342	13/34 (38%)
		FXa_inhibition	786..821	CDD:291342	9/34 (26%)
		FXa_inhibition	827..862	CDD:291342	11/34 (32%)
		FXa_inhibition	874..904	CDD:291342	11/34 (32%)
		FXa_inhibition	945..980	CDD:291342	14/34 (41%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
thbd	XP_012818722.2	CLECT	32..156	CDD:413318	32/178 (18%)
		FXa_inhibition	227..262	CDD:405372	13/34 (38%)
		cEGF	279..299	CDD:403760	9/19 (47%)
		EGF_CA	297..>327	CDD:214542	11/29 (38%)
		EGF_CA	336..>366	CDD:419698	10/30 (33%)
		vWFA	<414..451	CDD:412136	19/39 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010