DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment frac and efemp2

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:XP_002939376.2 Gene:efemp2 / 100379809 XenbaseID:XB-GENE-1013529 Length:442 Species:Xenopus tropicalis


Alignment Length:367 Identity:125/367 - (34%)
Similarity:154/367 - (41%) Gaps:92/367 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   651 PGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNH 715
            |.|| ..|..|||   .|..|.:|.||:||......|..::.|.|..|.|.|| ||..::..|:|
 Frog    24 PNSY-TECTDGYE---WDRERQHCRDINECQTIPDACKGELKCINHYGGYLCL-PPSASVISDSH 83

  Fly   716 IVTSLNSSFITD-STSSETPSAHTCLDIDECSLANGNCSHFCQNEPGGFQCACPLGYALS-EDMR 778
                      || .||...|..                .|.....|.    .||.||.|. ....
 Frog    84 ----------TDHGTSDFQPPV----------------DHGLDQRPN----PCPSGYQLDPHGQG 118

  Fly   779 TCQDIDECLDSNGQC--SQLCLNQPGGFACACETGFELTPDGF-----GCADIDECSQDYGNCSD 836
            ||.|.|||.:....|  ||.|:|..|.:.|.|       |||:     .|.|||||...|  |..
 Frog   119 TCVDFDECENERHDCLPSQECVNMLGSYHCKC-------PDGYRKIGNECVDIDECRYRY--CQH 174

  Fly   837 ICINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCSHECINKAGTFECGCPLGYILNDDG 901
            .|:|..|:.||.||.|::||.:..||:||:||.  :...|...|.|..|||.|.|..||.|:.| 
 Frog   175 RCVNYPGSFACQCEPGFQLAANNRSCVDVNECN--MGTPCQQRCYNTYGTFLCRCNQGYELSHD- 236

  Fly   902 RSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDECQKQNGGCSHRCSNTEGSFKCS 966
                                        |||      |.|||||...:..|.::|.|..|.|.||
 Frog   237 ----------------------------GYT------CTDIDECSYSSYLCQYQCVNEPGRFSCS 267

  Fly   967 CPPGYELDSDQKTCQDIDECDQDKTSCI-TGTCINEIGGFRC 1007
            ||.||:| ...:.||||:||:....||. ..||:|..||.:|
 Frog   268 CPEGYQL-LGTRLCQDINECELGTHSCSEQQTCVNFHGGHQC 308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342
cEGF 396..415 CDD:289433
FXa_inhibition 425..458 CDD:291342
FXa_inhibition 476..505 CDD:291342
vWFA <550..586 CDD:294047
FXa_inhibition 596..630 CDD:291342
FXa_inhibition 636..>664 CDD:291342 6/12 (50%)
EGF_CA 676..715 CDD:284955 14/38 (37%)
FXa_inhibition 745..780 CDD:291342 7/35 (20%)
FXa_inhibition 786..821 CDD:291342 12/41 (29%)
FXa_inhibition 827..862 CDD:291342 13/34 (38%)
FXa_inhibition 874..904 CDD:291342 12/29 (41%)
FXa_inhibition 945..980 CDD:291342 13/34 (38%)
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
DUF5011 1468..1536 CDD:295940
efemp2XP_002939376.2 EGF_CA 122..>155 CDD:311536 15/39 (38%)
EGF_CA 163..192 CDD:214542 15/30 (50%)
cEGF 182..205 CDD:372248 11/22 (50%)
vWFA <197..239 CDD:381780 19/72 (26%)
vWFA <240..275 CDD:381780 18/35 (51%)
EGF_CA 282..>309 CDD:389777 12/27 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24034
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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