DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and LOC100333499

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_021323601.1	Gene:	LOC100333499 / 100333499	-ID:	-	Length:	2049	Species:	Danio rerio

Alignment Length:	1630	Identity:	406/1630 - (24%)
Similarity:	576/1630 - (35%)	Gaps:	508/1630 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LDMS---CSSAKILPPE-------INHGRVSVFDRRR--------------RGKKVFLVAFF--- 84
            ||.|   |.|.|::..|       :|.|..|:...|.              .|||..|..||
Zfish   565 LDASHGICISQKVISEEKDQCFRILNQGACSLPILRNITKQICCCSRVGKAWGKKCELCPFFGSA 629

  Fly    85 ----VCDDNYDFENGISEMFCSNQKWVDEIPTCIPQLNFEEHDEKVGYDLEDYSDETVPNDYVEN 145
                :|.....:....|.:.. ||:..|.:.:....:.....|::...:....:.::.......|
Zfish   630 AFKEICPAGPGYHYSASAVKI-NQRVADIVDSSGTNVRTSTQDKQTQPESSRTNSQSTRTQQTSN 693

  Fly   146 SDIDEDDDEEVSEREPPPPPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPALAET---ETEN 207
            :.........:|:...|..|                      |..:.::.::|.|.:.   .|.|
Zfish   694 THTIRVQQPSISQSSRPQQP----------------------DTGSVIIITQPKLNQPTAGRTTN 736

  Fly   208 EVLEN---ETPLKAEVQTDVLNSSNASVKVTNDPYE------------PTFLD--------NNCG 249
            ....|   .|...|.|.|.|:.:..:...|...|..            ||..|        ..||
Zfish   737 IHAGNSPSSTSQPARVNTPVIRTQTSRPSVNRQPVSPVRPPPVTPRPPPTRQDVRVCESRPQVCG 801

  Fly   250 EDNGGCAHICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLESNGGCS-EICENLPGE 313
            .  |.|..:      |...   :.|.|..|:.|:|.. ..|.|.:||:.:...|| ..|.|.||.
Zfish   802 P--GRCIDL------PGGR---HTCVCNTGFILNPQQ-GHCQDKNECVLTPRPCSVGECVNTPGS 854

  Fly   314 YKCSCQEGYYLDESGKSCVDINECANPELSSNC-QGACENLPGSYRCV----EPLEENP--EITE 371
            ::|.|..||..:.....|||::||.  ::.:.| .|.|||..||:|||    ..|::|.  :|.|
Zfish   855 FRCVCPAGYQTNSQQTLCVDLDECR--QVPNPCINGRCENTLGSFRCVCRTGYKLQDNSCIDIDE 917

  Fly   372 VVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINECE------VDGPEDLDNNAVC 430
            .|: |:....:..|| |:......:|..||.| .:| .|.||:||.      .||
Zfish   918 CVD-PLRCPGKECVN-SQGSYRCVSCRPGFDL-LNG-QCSDIDECRRTPSPCPDG---------- 968

  Fly   431 QQKCENTIGSFRCTCVEGYHL----------LEDQRSCALDSCTDLENPQ----------LNRTR 475
              :||||.|||||:|..||.|          .||...|....|.:.:...          |....
Zfish   969 --RCENTAGSFRCSCRTGYRLQANTCVDVNECEDPSQCPGQECLNSQGSYRCVSCRPGFGLRNGA 1031

  Fly   476 CA--HECQDLPE-----------GSYRCVCPKGYELS----EDQHSCLVQESPCSTEKGVEKCSP 523
            |:  .||:..|.           ||:||||..||.|.    .|.:.|   |.|       .:|..
Zfish  1032 CSDIDECRQTPSPCQNGLCENTLGSFRCVCRTGYRLQGGTCTDVNEC---EDP-------SQCPG 1086

  Fly   524 GTCLASEDNTSFSCI-CPTGYRSEAFSCQDIDECAEDTHLC-SHTCQNTPGGYQCQCPEGLNLVE 586
            ..||.|:.  |:.|: |..|:.....:|.|||||.:...|| :..|:||.|.|.|.|..|..| |
Zfish  1087 QECLNSQG--SYRCVSCRPGFGLRNGACSDIDECRQTPDLCVNGRCENTMGSYSCSCRPGFRL-E 1148

  Fly   587 EYTCLAENLCEVNNNGCEQI-CLTARGGV-C-ACREGFRLSADGKSCEDVDECLVNNGGCQQ-VC 647
            |..|...|.|| |...|..: |:.:.|.. | :|:.||:| .||: |:|||||......|.. .|
Zfish  1149 ENICKDVNECE-NELQCPGMECVNSVGSFKCVSCKPGFQL-LDGQ-CQDVDECSRTPRRCTNGQC 1210

  Fly   648 RNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCL-CPPGYALG 711
            :|.|||:.|:|..|:.|  .||:   |.|:|||..... |..|. |.|..|||.|: |..|:::
Zfish  1211 KNTPGSFRCVCDVGFHL--QDGV---CTDMDECVDPLQ-CPGQQ-CINSPGSYKCVPCRDGHSM- 1267

  Fly   712 LDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGNC--SHFCQNEPGGFQCACPLGYALS 774
                                   .:..|.||||| :::..|  ...|.|..|.::|.|..||..:
Zfish  1268 -----------------------QSGRCTDIDEC-VSDQVCGAQSVCVNTDGSYRCDCAPGYRAA 1308

  Fly   775 EDMRTCQDIDECLDSN-----GQCSQLCLNQPGGFACACETGFELTPDGFGCADIDECSQDYGNC 834
            ...|.|:||:|||:.:     |:    |:|..|.:.|.|..|::...:|..|.|:|||:.| |.|
Zfish  1309 GAGRQCRDINECLEGDFCFPRGE----CVNTDGSYKCVCSQGYKSVANGTSCQDVDECALD-GVC 1368

  Fly   835 SD-ICINLLGTHACACERGYELAKDKLSCLDVDEC---AGLLSGGCSHECINKAGTFECGCPLGY 895
            .| .|.|..|:..|.|:.|:....:|.:||||:||   .||:.|  |..|.|..|:|.|
Zfish  1369 QDGRCSNTEGSFLCHCQTGFTTNPEKTACLDVNECQDSTGLICG--SQRCENTIGSFHC------ 1425

  Fly   896 ILNDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDECQKQNGGCSHR-CSNT 959
                                        ...|.|||.:.|..:|||::||..:....:|. |.|.
Zfish  1426 ----------------------------VASCEPGYQITSTAECVDVNECANETVCGAHAFCQNL 1462

  Fly   960 EGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEF--------------- 1009
            .|::.|.|..|||...|.|.|.||:||:..:..|.:..|.|..|.|.||.
Zfish  1463 IGTYHCLCDQGYESTGDGKICVDINECEAMQGVCGSARCWNVEGSFTCECENGQEEFDPIAGRCL 1527

  Fly  1010 -------------PKFPVLPEIPTAS---SLPESPKIELKTPKYPDFTELSNEIPENPKKPAEFD 1058
                         ..|.....:.:||   |||:|...|.|...|
Zfish  1528 SREGTGVSGSSGRSSFSSSGSVSSASASRSLPQSRPGEQKECYY--------------------- 1571

  Fly  1059 YPEPKFPSLPKWEGLPKLPPLADIPTSKAPVPLRPEVPKSLWVN-QLQ--------------PRD 1108
                         |:.                 :|...|.|.|| .||              ..|
Zfish  1572 -------------GIS-----------------QPYSCKILAVNTTLQECCCTAGQGWGLMCKYD 1606

  Fly  1109 LCP-----RFQ--APRNGKSH----CNRYRHKQ----KLFYYSRCR------------ISCNSGY 1146
            :||     .||  .| |||.:    ...:.:|.    |||....|:            ..|.||.
Zfish  1607 ICPEAGTAEFQTLCP-NGKGYVTTEAGAFNYKDVDECKLFDPEVCKGGTCVNNIPGYACYCRSGS 1670

  Fly  1147 ILQGPEIKSCDANGIWEGPET----KCVAINQPRAQSPGICPALKP-----AQNGVILPASCTQG 1202
            ... .|:..|..|...|..:|    :||     ..|....|....|     .|...:..:..|:.
Zfish  1671 YYD-TELLECTDNDECESEDTCSGGRCV-----NTQGTFYCTCEPPLVLDDTQRNCVNASGLTED 1729

  Fly  1203 PSRFGDVCRLQCNAGFVSTGSLLTA------CMMLQGWSFGADLNC------------------- 1242
            .|.  :.|.....||.|....||.|      |..|.|.::|  |.|
Zfish  1730 ESL--NFCWRHVTAGLVCQSPLLGAQLSFSECCCLYGEAWG--LQCALCPRRDEEAYEALCNEFG 1790

  Fly  1243 ---------QPFGNGLL---GNQLSPMWNSPKTVTPHQIQNVEQIRP-YINCPENVVILLHAGEQ 1294
                     :.||.|.|   |..|.|       ..|.:...:...|| ||  |.:......||.:
Zfish  1791 PPPYSPRYYERFGPGPLPGRGGYLPP-------YGPPEFPELLPGRPDYI--PTDYDDYSPAGGR 1846

  Fly  1295 KAHVTLQRPQTNVKNGRLVAHPAWAGQLQGHLPAGVHKVD----------FRVNDPETKLTIKCH 1349
            ::.:..:.|.:..........||         |.||...:          |.|.||      :..
Zfish  1847 RSGLRERTPGSYGLPDPSYRQPA---------PGGVRYYEDDYDPAPGPPFGVPDP------RGE 1896

  Fly  1350 TIITVKAATPR-ESNPFTLFRISDYSRSSLPRPAPFATLSTGSSFSFPAFKALDATPKPVSFTKF 1413
            .:...:...|| :..|.:|        :.||..:|::......|:         ..|.|     |
Zfish  1897 RMFDARPLPPRADGRPLSL--------APLPENSPYSEAEEAESW---------RAPPP-----F 1939

  Fly  1414 QVFPD 1418
            .:|||
Zfish  1940 PMFPD 1944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	11/35 (31%)
		cEGF	396..415	CDD:289433	8/18 (44%)
		FXa_inhibition	425..458	CDD:291342	15/42 (36%)
		FXa_inhibition	476..505	CDD:291342	14/45 (31%)
		vWFA	<550..586	CDD:294047	17/36 (47%)
		FXa_inhibition	596..630	CDD:291342	13/36 (36%)
		FXa_inhibition	636..>664	CDD:291342	10/28 (36%)
		EGF_CA	676..715	CDD:284955	14/39 (36%)
		FXa_inhibition	745..780	CDD:291342	10/36 (28%)
		FXa_inhibition	786..821	CDD:291342	10/39 (26%)
		FXa_inhibition	827..862	CDD:291342	12/35 (34%)
		FXa_inhibition	874..904	CDD:291342	7/29 (24%)
		FXa_inhibition	945..980	CDD:291342	12/35 (34%)
		CCP	1110..1170	CDD:153056	21/90 (23%)
		CCP	1183..1235	CDD:153056	15/62 (24%)
		DUF5011	1468..1536	CDD:295940
LOC100333499	XP_021323601.1	EGF_CA	533..>563	CDD:214542
		TB	594..634	CDD:307020	8/39 (21%)
		SSL_OB	644..>767	CDD:332684	20/145 (14%)
		EGF_CA	832..865	CDD:214542	13/32 (41%)
		EGF_CA	874..908	CDD:238011	13/35 (37%)
		EGF_CA	914..>945	CDD:214542	8/32 (25%)
		EGF_CA	954..988	CDD:238011	18/45 (40%)
		EGF_CA	994..1029	CDD:238011	5/34 (15%)
		EGF_CA	1034..1073	CDD:214542	12/38 (32%)
		EGF_CA	1074..1109	CDD:238011	12/46 (26%)
		EGF_CA	1114..1146	CDD:214542	15/31 (48%)
		EGF_CA	1194..1226	CDD:214542	14/31 (45%)
		EGF_CA	1274..1314	CDD:214542	14/40 (35%)
		EGF_CA	1316..1357	CDD:214542	13/44 (30%)
		EGF_CA	1358..1390	CDD:214542	14/32 (44%)
		EGF_CA	1443..1484	CDD:214542	14/40 (35%)
		TB	1582..1619	CDD:307020	10/36 (28%)
		EGF_CA	1681..>1709	CDD:214542	7/32 (22%)
		TB	1745..1785	CDD:307020	9/41 (22%)
		Atrophin-1	<1815..1950	CDD:331285	33/176 (19%)
		cEGF	1985..2008	CDD:315355
		EGF_CA	2005..2042	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020