DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and si:ch73-105b23.6

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_021336607.1	Gene:	si:ch73-105b23.6 / 100332400	ZFINID:	ZDB-GENE-081107-42	Length:	2596	Species:	Danio rerio

Alignment Length:	1839	Identity:	451/1839 - (24%)
Similarity:	610/1839 - (33%)	Gaps:	671/1839 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 VQTDVLNSSNASVK--VTNDPYEPTFLDNNCGEDNGGCAH---ICKRLLYPDENQPINK-----C 274
            |.|:.|.|...|.:  .:.|.::...: |.|..:||.| |   :|           .||     |
Zfish    81 VCTNTLGSYTCSCQNGYSGDGFQCQDI-NECQTNNGDC-HANALC-----------TNKDGGRDC 132

  Fly   275 DCREGY-------------------------TLDPNDYAS-------------CLDIDECLESNG 301
            .||.|:                         |.:|..|..             |||:|||.|:.|
Zfish   133 SCRSGFSGNGFQCTDDNECARPGICHWNATCTNNPGSYVCTCNSGYKGNGNYLCLDVDECSETPG 197

  Fly   302 GCSEI-----CENLPGEYKCSCQEGYYLDESGKSCVDINECANPELSSNCQ--GACENLPGSYRC 359
            .||.:     |:||.|.|.|.|..||  ..:|::|||||||.    .:.|.  ..|.||||||||
Zfish   198 VCSALLGYKGCKNLQGTYTCLCNSGY--QSNGQTCVDINECQ----INFCSPFADCTNLPGSYRC 256

  Fly   360 VEPLEENPEITEVVE-NPIEKTNEVPVNVSESQPAGK---TCNSGFQLSADGTDCQDINECEVDG 420
            ..|...|......|: |..::.|....|...:...|.   :|.|||  ...||.|.|||||..|.
Zfish   257 TCPEGFNGNGLACVDINECDRKNSCDPNALCTNLLGSYKCSCRSGF--LGIGTKCTDINECATDN 319

  Fly   421 PEDLDNNAVCQ--QKCENTIGSFRCTCVEGYHLLEDQRSCALDSCTDLENPQLNRTRCAHECQDL 483
                    :|.  ..|.||.|||.|.|.:||:..::|       |.||:...:........|:::
Zfish   320 --------ICPAVAACVNTAGSFFCDCGQGYNFTQNQ-------CVDLDECAIGLCSPYASCENM 369

  Fly   484 PEGSYRCVCPKGYE----LSEDQHSCLVQE----------SP----CS-----TEKGVEKCSP-- 523
            | |||:|.|..|::    :.||...|:.::          ||    ||     |..||.:|:.
Zfish   370 P-GSYKCSCIAGFKGDGLVCEDVDECVTEKRCHVNALCINSPGKYNCSCMVGYTGNGVSQCTDIN 433

  Fly   524 ------GTC----LASEDNTSFSCICPTGYR-SEAFSCQDIDECAEDTHLC--SHTCQNTPGGYQ 575
                  |.|    ..|....|:|||||:|:| ....:|||||||.....:|  :..|.|..|.|.
Zfish   434 ECLVDNGGCKNRATCSNSKGSYSCICPSGFRLVNHTTCQDIDECQLPEKVCGTNEQCTNLEGSYS 498

  Fly   576 CQCPEG---------------------------LNLVEEYTCLAENLCEVNNNGCEQICLTARGG 613
            |||..|                           ||||..|:|..::..:.|...||.|...|.||
Zfish   499 CQCKAGFSRIIDDFCSDINECDIQKPCHQNATCLNLVGSYSCTCKSGFKGNGVTCEDINECALGG 563

  Fly   614 V---------------CACREGFRLSADGKSCEDVDECLVNNGGCQ--QVCRNLPGSYGCICAAG 661
            :               |.|.:||  :.||.:|.|||||.|:|..|.  .||.|..|:|.|.|..|
Zfish   564 ICHLHANCYNYIGEYLCVCHQGF--TGDGVTCTDVDECYVSNATCPGISVCVNSLGAYVCSCLNG 626

  Fly   662 ---------YELLKLD----------------------GIRG---YCFDIDECSQRTHGCSD-QM 691
                     :..|:.|                      |.:|   .|.|||||.:..  |.: :.
Zfish   627 TVAYNNTCVFPSLECDPACHPHGLCHPSPSGFQCVCDVGFKGDGLTCSDIDECEENV--CPEKET 689

  Fly   692 LCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSE--------------TPSAHTCL-- 740
            .|.|..||:.|.|..||          |.|.:..||....|              |..:|.|.
Zfish   690 QCVNNPGSFECTCKEGY----------SFNGTKCTDLDECESGVSNCSKFAQCVNTVGSHLCFCL 744

  Fly   741 -----------DIDECSLANGNCSHF--CQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNG- 791
                       ||:||...||.|...  |.|.||.|:|.||||  ::.....|||:||| ::|.
Zfish   745 SGFTGDGKNCSDINECHFQNGGCHPVASCTNSPGSFKCTCPLG--MTGSGFDCQDVDEC-NANST 806

  Fly   792 ---QCSQL--CLNQPGGFACACETGFELTPDGFGCADIDEC------------------------ 827
               .||.|  |.|..|.:.|.|..|:  ..:||.|:|:|||
Zfish   807 LPHNCSLLSTCHNTEGSYICKCMEGY--WGNGFTCSDLDECFPPSICGNNMTCQNFPGTFTCTCT 869

  Fly   828 ---SQDYGNC---SDI------------CINLLGTHACACERGYELAKDKLSCLDVDECAGLLSG 874
               ..|.|.|   .|.            |.|:.|::.|:|.:|:.  .:...|.|:|||:.:  |
Zfish   870 LGLVYDLGTCVTEKDCKNATNACNIYAECKNVHGSNYCSCMKGFH--GNGRDCKDLDECSQI--G 930

  Fly   875 GCSH--ECINKAGTFECGCPLGYILN----DDGRSCSPALVGCP-PGTQRSADGCAPIECNPGYT 932
            .|.:  .|.|..|:|.|.|..||..|    ||...||.....|| ..|..:..|.....||.|:.
Zfish   931 ACPNLSNCFNTEGSFHCDCLQGYQYNGTHCDDINECSVGNFSCPVNSTCYNEVGGYNCSCNNGFI 995

  Fly   933 LGSDDKCVDIDECQK----------------------------------------QNGGCSHR-- 955
            ...:..|:|:|||..                                        .|..||..
Zfish   996 YSYNSVCLDVDECATGKAQCPNASNCHNTVGSYYCECWDGYIGNQTICEDVNECLNNSRCSDHSI 1060

  Fly   956 CSNTEGSFKCSCPPGYELDSDQKT-CQDIDEC-DQDKTS-CITGTCINEIGGFRCEFPKFPVLPE 1017
            |.||.|||.|.|..|:.|:....| |:||||| :.|..| |..|||:|.||.|.|
Zfish  1061 CVNTLGSFMCLCDDGFTLNGTSDTQCEDIDECSNPDNGSICTNGTCLNTIGSFGC---------- 1115

  Fly  1018 IPTASSLPESPKIELKTPKYPDFTELSNEIPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADI 1082
                               ..|....||       ..:.||..|   .|..:.|.:.:|....
Zfish  1116 -------------------VCDMGFRSN-------GTSCFDIDE---CSGSQNESICQLHSTC-- 1149

  Fly  1083 PTSKAPVPLRPEVPKSLWVNQLQPRDL--CPRFQAPRNGKSHCNRYRHKQKLFYYSRCRISCNSG 1145
              |..|...:........:|:.:.:|:  |....:|....|.|        :......|..|.||
Zfish  1150 --SNIPGSYKCHCDSGFLLNRTECQDIDECLADDSPCTANSVC--------INSVGSFRCLCASG 1204

  Fly  1146 YILQG---PEIKSCDANGIWEGPETKCVAINQPRAQSPGICPALKPAQNGVILP----------- 1196
            :...|   .:|..|.:||... |:..|  ||:|.:.... ||.....::|..:.
Zfish  1205 FKEDGLKCTDINECLSNGTCR-PDQVC--INKPGSYLCS-CPPGHQEESGNCIDNNECANNTTCH 1265

  Fly  1197 --ASCTQGPSRFGDVCRL-------------------------------------QCNAGFVSTG 1222
              |.|......|...|||                                     .|.||||:.|
Zfish  1266 PLARCWNTVGTFTCQCRLGYVGNGTYCKDIDECSTSSSRCHKSSKCINTPGSYVCVCAAGFVALG 1330

  Fly  1223 SL---LTACMMLQGW---------SFGADLNCQPFGNG---LLGNQ------------LSPMWN- 1259
            |:   |..|...:|.         |.|. ..|| .|||   .:||.            |||  |
Zfish  1331 SVCVDLDECQANRGICHPAATCYNSIGG-FQCQ-CGNGWDASVGNGRGMGGCIDQNECLSP--NV 1391

  Fly  1260 ------------------SPKTVTPHQIQNVEQ---------------------IRPYINCPENV 1285
                              ||:.....|:..:|.                     |.|||..|..
Zfish  1392 CYRNRTCTNFIGSYSCACSPRDTHCSQLSLMESDLYPFGEEAGDAKLTITTADGISPYILPPTG- 1455

  Fly  1286 VILLHAGEQKAHVT-----LQRPQTNVKNGRLVAHPAWAGQLQGHLPAGVHKVDFRVNDPETKLT 1345
              .|..|:|...:.     |.:.|:..:|.:|:        |...:|.|.|
Zfish  1456 --FLFMGKQYERLLFSDNGLVQFQSVNENEKLL--------LPAPIPKGFH-------------- 1496

  Fly  1346 IKCHTIITVKAATPRESNPFTLFRISDYSRSSLPRPAPF-----ATLSTG----SSFSFPAFKAL 1401
                                        ...|||..|.|     .||..|    ..:|||
Zfish  1497 ----------------------------GNESLPMLAVFWDDADLTLGDGKLLYQEYSFP----- 1528

  Fly  1402 DATPKPVSFTKFQVFPDSESSEHSKLGSSSFFRLEPLFHESSKLISAAPASSENTRVDLGSDTSN 1466
             ..|...:.|.|.......|...|:.|...|   .|::..........|.|.:  :::|....:.
Zfish  1529 -NVPDIYALTVFNRTAQDVSRFESQRGKPPF---TPIWILKITWDHVLPVSYQ--KINLSETNTF 1587

  Fly  1467 YCPPSIEVYLKENQNLRSVV--------WDE-PRFEGKLLKIY---KSHF-------PGSLFKVG 1512
            .|       :.....|||..        |.. .|.....|..|   |::|       |.:||..|
Zfish  1588 QC-------ILTTDGLRSFALLRYGDMNWGPGQRTHHDALIGYTDGKNNFHNEIPNPPNNLFNSG 1645

  Fly  1513 DHAIKYEATTTDGKTLSCTFFIY------VRSAKP----------TPAPTEPKISFDSEPETLSD 1561
            .   :|...|..|.|......:|      ..|:.|          .|.|.|..:...:.|.|...
Zfish  1646 G---RYRPQTVTGNTGELGKLVYDLTGSDKTSSDPQRQCHIWAFSEPDPKEWALGLATCPCTRVQ 1707

  Fly  1562 VSQTYVVCPDKEPVRVTAE 1580
            ..:.....|:..|...||:
Zfish  1708 AQEDLAFGPETLPSEQTAQ 1726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	15/39 (38%)
		cEGF	396..415	CDD:289433	9/18 (50%)
		FXa_inhibition	425..458	CDD:291342	12/34 (35%)
		FXa_inhibition	476..505	CDD:291342	10/32 (31%)
		vWFA	<550..586	CDD:294047	19/64 (30%)
		FXa_inhibition	596..630	CDD:291342	13/48 (27%)
		FXa_inhibition	636..>664	CDD:291342	12/38 (32%)
		EGF_CA	676..715	CDD:284955	14/39 (36%)
		FXa_inhibition	745..780	CDD:291342	14/36 (39%)
		FXa_inhibition	786..821	CDD:291342	13/40 (33%)
		FXa_inhibition	827..862	CDD:291342	11/76 (14%)
		FXa_inhibition	874..904	CDD:291342	13/35 (37%)
		FXa_inhibition	945..980	CDD:291342	15/77 (19%)
		CCP	1110..1170	CDD:153056	14/62 (23%)
		CCP	1183..1235	CDD:153056	19/113 (17%)
		DUF5011	1468..1536	CDD:295940	19/92 (21%)
si:ch73-105b23.6	XP_021336607.1	EGF_3	69..104	CDD:315598	6/22 (27%)
		EGF_3	110..145	CDD:315598	12/46 (26%)
		EGF_3	153..184	CDD:315598	3/30 (10%)
		EGF_CA	232..>262	CDD:214542	16/33 (48%)
		EGF_CA	271..304	CDD:238011	8/34 (24%)
		EGF_CA	311..>342	CDD:214542	15/38 (39%)
		EGF_3	358..388	CDD:315598	8/30 (27%)
		EGF_CA	390..423	CDD:238011	6/32 (19%)
		EGF_CA	431..467	CDD:238011	11/35 (31%)
		EGF_CA	473..506	CDD:214542	14/32 (44%)
		EGF_3	524..553	CDD:315598	7/28 (25%)
		EGF_3	563..593	CDD:315598	7/31 (23%)
		EGF_3	645..673	CDD:315598	2/27 (7%)
		EGF_CA	675..714	CDD:214542	16/50 (32%)
		EGF_3	719..754	CDD:315598	4/34 (12%)
		EGF_3	760..795	CDD:315598	14/36 (39%)
		EGF_3	808..839	CDD:315598	11/32 (34%)
		EGF_CA	841..880	CDD:238011	6/38 (16%)
		EGF_CA	922..961	CDD:214542	15/40 (38%)
		EGF_CA	962..>994	CDD:328759	9/31 (29%)
		EGF_CA	1004..>1036	CDD:311536	4/31 (13%)
		EGF_CA	1045..1077	CDD:214542	12/31 (39%)
		EGF_CA	1088..1128	CDD:214542	19/75 (25%)
		EGF_CA	1130..1169	CDD:214542	8/45 (18%)
		EGF_CA	1173..1213	CDD:214542	10/47 (21%)
		EGF_CA	1214..1247	CDD:214542	11/36 (31%)
		EGF_3	1260..1292	CDD:315598	6/31 (19%)
		EGF_CA	1294..1334	CDD:214542	7/39 (18%)
		EGF_CA	1335..>1367	CDD:214542	9/33 (27%)
		EGF_CA	1382..>1411	CDD:214542	4/30 (13%)
		NIDO	1506..1646	CDD:322035	31/157 (20%)
		VWD	1836..2005	CDD:321964
		EGF_3	2290..2319	CDD:315598
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010