DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and si:dkey-163f14.6

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	XP_009304399.1	Gene:	si:dkey-163f14.6 / 100332398	ZFINID:	ZDB-GENE-141215-18	Length:	740	Species:	Danio rerio

Alignment Length:	817	Identity:	190/817 - (23%)
Similarity:	303/817 - (37%)	Gaps:	252/817 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 PPEINHGRVSVFDRRRRGKKVFLVAFFVCDDNYDFENGISEMFCSNQKWVDEIPTC-------IP 115
            |.::.||. :|..|.|.      :|.|.||..: :.:|.:.::|..:.|....|.|       :.
Zfish    86 PGDLLHGS-AVVSRDRS------LASFSCDAGF-YLSGSALLYCKGKNWNSTKPVCKVADIMSVL 142

  Fly   116 QLNFE---------------EHDEKVGYDLEDYSDETVPNDYVE--NSDIDEDDDEEVSEREPPP 163
            .||.|               .|.......:..:.|..:.:..:|  :..:|..||::.|.:....
Zfish   143 HLNQEFLHGPAYVPTSLKNHLHSHLNTMAITAHKDTFLKSALLEVPHVTLDLTDDKQTSRKPVEK 207

  Fly   164 PPPPPVVDGADSKPEPQIVIEINDDHANEVVESEPALAETET-------ENEVLENETPLKAEVQ 221
            .|...|:..|:....|:.:.::  ..::::.:..|..:...|       .|.:|   |...:...
Zfish   208 KPSKSVLFAAEPIKNPENIKDL--IRSSDLQKPVPVTSNVNTMSFASSFYNFIL---TTTSSSFN 267

  Fly   222 TDVLNSSNASV---KVTNDPY---EPTFLDNNCGEDNGGCAHICKRLLYPDENQPINKCDCREGY 280
            |..:||....:   ..|..||   |..: .:.|..|........:|||...:|:|:.
Zfish   268 TPSVNSQQVKIMDQMFTETPYRRNEKGY-QSTCVTDTTSVTTSAERLLEYLKNKPLT-------- 323

  Fly   281 TLDPNDYASCLDIDECLESNGGCSEICENLPGEYKCSCQE------GYYLDESGKSCVDINECAN 339
            ||.||  .:.|..::.|:|.     |.:|   |:..:.:.      .:.|.|        ||.||
Zfish   324 TLAPN--INTLGTNDYLQSG-----ILDN---EHSATFKSPTASYPRFMLSE--------NESAN 370

  Fly   340 ---PELSSNCQGACE-NLPGSYRCVEPL---EENPEITEVVEN--PIEKTNEVPVNVSESQPAGK 395
               |...|.|:|.|| ::..:.....|:   ..:.:||::..:  |:: .:....|..:.|...|
Zfish   371 YLKPTAPSTCRGLCEQDVQKTSPSTNPIGHASSSMQITKIASDLPPVD-VHRFIYNAEDQQVNDK 434

  Fly   396 TCNSGFQLSADGTDCQDINECEVDGPEDLDN-----NAVCQQKCENTIGSF-------------- 441
            :..|..:|:.:..             |||.:     ..||......:.|:|
Zfish   435 SNQSDVKLTFESL-------------EDLPSFPTRKRPVCPYPPFPSHGTFYFRSIKNPGPLQYK 486

  Fly   442 ---RCTCVEGYHLL----------EDQRSCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCP 493
               :..|..||.|.          :.|.|.....|.:|....|:...|:..|:.......:|||.
Zfish   487 HYIQYACYPGYTLTSGDVYSYCEHDGQWSGQTPLCLELTPCSLHNGGCSQICRVNEHHRAQCVCK 551

  Fly   494 KGYELSEDQHSCLVQESPCSTEKGVEKCSPGTCLASEDNTSFSCICPTGYRSEAFSCQDIDECAE 558
            .|:.|.|||.                                             :|:|:|||.|
Zfish   552 PGFLLLEDQR---------------------------------------------TCRDLDECVE 571

  Fly   559 DTHLCSHTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRL 623
            :.|||...|:||.|.|:                                       |:|..||:|
Zfish   572 ELHLCQQACENTLGSYR---------------------------------------CSCSPGFQL 597

  Fly   624 SADGKSCEDVDEC-LVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDEC-SQRTHG 686
            ||||.||.||||| ||....|:..|.|.|||:.|:||.|::   ||....:|.||:|| .::.|.
Zfish   598 SADGTSCSDVDECQLVGRALCEFGCINTPGSFQCLCAEGHQ---LDSTNRHCIDINECEEEQLHM 659

  Fly   687 CSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANGN 751
            |  :..|.||.|:|.|:||.||.|    |                  .:.|.|.||:||.|.||:
Zfish   660 C--EWKCVNLPGTYKCICPRGYRL----H------------------SNRHQCEDINECELKNGS 700

  Fly   752 CSHFCQNEPGGFQCACPLGYALSE-DMRTCQDIDECL 787
            |||.|.|..|.::||||..:.:|. :.:.|..::..|
Zfish   701 CSHLCINHRGDYKCACPETHRISPYNPKNCLPVERHL 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	7/40 (18%)
		cEGF	396..415	CDD:289433	2/18 (11%)
		FXa_inhibition	425..458	CDD:291342	9/64 (14%)
		FXa_inhibition	476..505	CDD:291342	10/28 (36%)
		vWFA	<550..586	CDD:294047	14/35 (40%)
		FXa_inhibition	596..630	CDD:291342	9/33 (27%)
		FXa_inhibition	636..>664	CDD:291342	13/28 (46%)
		EGF_CA	676..715	CDD:284955	17/39 (44%)
		FXa_inhibition	745..780	CDD:291342	15/35 (43%)
		FXa_inhibition	786..821	CDD:291342	1/2 (50%)
		FXa_inhibition	827..862	CDD:291342
		FXa_inhibition	874..904	CDD:291342
		FXa_inhibition	945..980	CDD:291342
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
si:dkey-163f14.6	XP_009304399.1	CCP	28..79	CDD:153056
		CCP	83..133	CDD:214478	14/54 (26%)
		CCP	461..521	CDD:214478	9/59 (15%)
		FXa_inhibition	527..563	CDD:291342	11/80 (14%)
		EGF_CA	565..604	CDD:284955	22/77 (29%)
		EGF_CA	606..647	CDD:214542	19/43 (44%)
		EGF_CA	648..689	CDD:214542	19/64 (30%)
		FXa_inhibition	694..730	CDD:291342	15/35 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910