DRSC/TRiP Functional Genomics Resources

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Protein Alignment frac and fbn1

DIOPT Version :9

Sequence 1:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster
Sequence 2:XP_017207479.2 Gene:fbn1 / 100330961 ZFINID:ZDB-GENE-091204-466 Length:2768 Species:Danio rerio


Alignment Length:1291 Identity:350/1291 - (27%)
Similarity:482/1291 - (37%) Gaps:448/1291 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   273 KCDCREGYTLDPNDYASCLDIDECLESNGGCSE-ICENLPGEYKCSCQEGYYLDESG----KSCV 332
            :|.|..|:.|| .|..:|.|||||..|...|.. .|.|..|:::|.|..||   |||    |:|:
Zfish  1092 RCRCDGGFALD-FDERNCTDIDECRISPDLCGHGTCVNTAGDFRCECFTGY---ESGFMMMKNCM 1152

  Fly   333 DINEC-ANPELSSNCQGA-CENLPGSYRCVEP--LEENPEITEVVE-NPIEKTNEVPVNVSESQP 392
            ||:|| .||.|   |:|. |.|..||:||..|  .|..|:.:..:: |..|.::::..|......
Zfish  1153 DIDECERNPLL---CRGGECINTEGSFRCQCPDGHEIAPDGSACLDINECELSDKLCRNGQCVNM 1214

  Fly   393 AGK---TCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLED 454
            .|:   :||:|::.:.|...|.||:||.::       |..|:..|.|:.||:.|:|..||.|:.|
Zfish  1215 IGRYQCSCNTGYKSTEDRLSCVDIDECTIE-------NGGCETFCTNSEGSYECSCRRGYALMPD 1272

  Fly   455 QRSCA-LDSCTDLENPQLNRTRC-AHECQDLPEGSYRCVCPKGYELSEDQHSCL-VQE------- 509
            .|||. :|.|.|  :|.:    | ..:|.::| |.::|:|..|:..|||..||| |.|       
Zfish  1273 LRSCTDIDECED--SPDV----CDGGQCSNIP-GEFQCLCFDGFMSSEDMKSCLDVNECELNPNI 1330

  Fly   510 ---SPCSTEKG---------------------VEKCSPG--------TCLASEDNTSFSCICPTG 542
               ..|...||                     :.:|..|        :|..|..  ||.|.|..|
Zfish  1331 CLSGKCENTKGSFICHCDLGFSVRKGTTGCTDINECEIGAHNCDHHASCTNSAG--SFRCSCAPG 1393

  Fly   543 YRSEAFSCQDIDECAEDTHLCSHT--CQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQ 605
            :......|.|:|||:..||.||.:  |:||.|.|:|.|.||.: .:.:.|...:.|..|.|.||.
Zfish  1394 WIGNGIKCTDLDECSNGTHHCSPSADCRNTMGSYRCLCKEGFS-GDGFYCTDTDECADNVNLCES 1457

  Fly   606 -ICLTARGGV-CACREGFRLSADGKSCEDVDEC----LVNNGGCQQVCRNLPGSYGCICAAGYEL 664
             .||...||. |.|..||..:||||:|||:|||    :..||.|.    |:||.:.|:|..||| 
Zfish  1458 GHCLNIAGGFRCECDMGFIPTADGKACEDIDECTFADICVNGRCS----NIPGLFRCLCDPGYE- 1517

  Fly   665 LKLDGIRGYCFDIDECSQRTHGCSDQMLCENLNGSYTCLCPPGY--------------------- 708
              ||...|.|.|::||:......|.  ||.|..|||.|.|||.:                     
Zfish  1518 --LDRSGGNCTDVNECNDPNTCISG--LCLNTPGSYICSCPPDFELNPTGVGCVDTRSGNCYLDV 1578

  Fly   709 --------ALGLDNHI-----------------------VTSLNSS---FITDSTSSETPSAHTC 739
                    :|...|.|                       ..||||:   .:........|:..|.
Zfish  1579 QYRGDFSESLSCSNEIGVGVSKASCCCSRGVAWGQPCEACPSLNSTEYKKLCPGGEGFRPNPITI 1643

  Fly   740 L--DIDECSLANGNC-SHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQ-LCLNQ 800
            :  ||:||....|.| ...|.|..|.|.|.||.|:||.||.|.|:|:|||.:. |.|.. .|.|.
Zfish  1644 ILEDINECQELPGLCQGGDCINTFGSFHCECPRGFALKEDTRICEDVDECANP-GICGPGQCYNT 1707

  Fly   801 PGGFACAC----------------------------------ETGFELTPDGFGCA--------- 822
            .|.:.|.|                                  |..|.:|.....|:         
Zfish  1708 IGNYTCICPPEYMQINGGNNCMDMRKSLCYRNYYSDNATCDGELTFNMTKKFCCCSYNIGRAWNK 1772

  Fly   823 ----------------------------------DIDECSQDYGNCSD-ICINLLGTHACACERG 852
                                              |||||.:..|.|.: :|||::|:..|.|..|
Zfish  1773 PCEKCPVPSTNEFAVLCGSERPGYFIDIYTGQIIDIDECREIPGVCENGVCINMIGSFRCECPMG 1837

  Fly   853 YELAKDKLSCLDVDECAGLLSGG--CSHE--CINKAGTFECGCPLGYILN------------DDG 901
            :......|.|.|:|||    ..|  |...  |:|..|:|.|.|..||...            ::.
Zfish  1838 FVYNDKLLICEDIDEC----QNGPVCQQNAVCLNVPGSFRCECKSGYRQTPTQQCVDRNECAENP 1898

  Fly   902 RSCSPA----LVG-----CPPGTQRSADGCAPIE----------------------CNPGYTLGS 935
            ..|||.    :||     ||.|.:.:.|.|..::                      |.||:.|..
Zfish  1899 NICSPGQCIDMVGSYRCICPNGFKSTPDLCIDVDECDRQPCGNGTCKNTVGSYNCLCYPGFQLSH 1963

  Fly   936 DDKCVDIDECQK-----QNGGCSH--------------------------------------RCS 957
            ::.|:|.|||..     :||.|.:                                      .|.
Zfish  1964 NNDCIDTDECVSLRGLCRNGNCINTVGSFVCVCLDGYKLSPDGRTCVDINECLLSPGTCGPGTCQ 2028

  Fly   958 NTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEIPTAS 1022
            |.:||::|.|||||.|..|:  |:|||||.|....||.|.|:|..|.||||.|:         ..
Zfish  2029 NLDGSYRCICPPGYYLQDDR--CEDIDECSQSPEICIFGKCVNTPGSFRCECPE---------GF 2082

  Fly  1023 SLPESPK--IELKTPK-YPDFTELSNEIPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIPT 1084
            .|..|.|  ::::... |..|        ||.:..|    |:|                   :.|
Zfish  2083 QLSSSGKRCVDIRVNYCYTKF--------ENGRCLA----PKP-------------------LNT 2116

  Fly  1085 SKAPVPLRPEVPKSLWVNQLQPRDLCPRFQ-------APRNGKSHCN-----------------R 1125
            :|: |.....:|...|.:   |.::||..:       .|..||||..                 |
Zfish  2117 TKS-VCCCSGMPGQGWGD---PCEICPSMEDAAFKVLCPAPGKSHSTDDTAVDVDECVQNPGICR 2177

  Fly  1126 YRHKQKLFYYSRCRISCNSGYIL---------------------------QGPEIKSCDANGIWE 1163
            ..|........||  .|..||.|                           :|....||| .|...
Zfish  2178 NGHCINTDGTFRC--ECPFGYRLDFTGINCEDTNECELGNPCGNGTCTNVEGAFECSCD-EGFEP 2239

  Fly  1164 GPETKCVAINQPRAQSPGICPALKPAQNGVILPASCTQGPSRFGDVCRLQCNAGFV 1219
            ||...|..:|:        |     :||.::....|......:  .||  |.||:|
Zfish  2240 GPMMTCEDVNE--------C-----SQNPLLCAFRCVNTVGSY--ECR--CPAGYV 2278

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342 14/39 (36%)
cEGF 396..415 CDD:289433 7/18 (39%)
FXa_inhibition 425..458 CDD:291342 13/32 (41%)
FXa_inhibition 476..505 CDD:291342 10/29 (34%)
vWFA <550..586 CDD:294047 18/37 (49%)
FXa_inhibition 596..630 CDD:291342 17/35 (49%)
FXa_inhibition 636..>664 CDD:291342 11/31 (35%)
EGF_CA 676..715 CDD:284955 15/67 (22%)
FXa_inhibition 745..780 CDD:291342 16/35 (46%)
FXa_inhibition 786..821 CDD:291342 11/69 (16%)
FXa_inhibition 827..862 CDD:291342 11/35 (31%)
FXa_inhibition 874..904 CDD:291342 10/45 (22%)
FXa_inhibition 945..980 CDD:291342 16/77 (21%)
CCP 1110..1170 CDD:153056 22/110 (20%)
CCP 1183..1235 CDD:153056 10/37 (27%)
DUF5011 1468..1536 CDD:295940
fbn1XP_017207479.2 TB 208..241 CDD:307020
EGF_CA 259..>289 CDD:214542
EGF_CA 301..342 CDD:214542
TB 358..401 CDD:307020
EGF_CA 531..565 CDD:214542
EGF_CA 571..612 CDD:214542
EGF_CA 613..>643 CDD:214542
EGF_CA 654..687 CDD:214542
TB 711..751 CDD:307020
EGF_CA 806..838 CDD:238011
TB 903..>931 CDD:307020
EGF_CA 951..992 CDD:214542
TB 1008..1047 CDD:307020
EGF_CA 1068..>1099 CDD:214542 2/6 (33%)
EGF_CA 1110..1144 CDD:214542 15/36 (42%)
EGF_CA 1153..1185 CDD:214542 16/34 (47%)
cEGF 1175..1198 CDD:315355 6/22 (27%)
cEGF 1218..1240 CDD:315355 7/21 (33%)
FXa_inhibition 1241..1276 CDD:317114 14/41 (34%)
EGF_3 1366..1401 CDD:315598 9/36 (25%)
EGF_3 1407..1442 CDD:315598 14/35 (40%)
EGF_CA 1444..1484 CDD:328759 17/39 (44%)
EGF_CA 1486..1526 CDD:214542 18/46 (39%)
EGF_CA 1527..1558 CDD:214542 14/32 (44%)
TB 1590..1629 CDD:307020 6/38 (16%)
EGF_CA 1647..1688 CDD:214542 19/40 (48%)
EGF_CA 1689..1728 CDD:214542 11/39 (28%)
TB 1747..1788 CDD:307020 4/40 (10%)
EGF_CA 1807..>1838 CDD:214542 13/30 (43%)
EGF_CA 1849..1881 CDD:214542 13/35 (37%)
EGF_CA 1930..1964 CDD:214542 4/33 (12%)
cEGF 1991..2014 CDD:315355 0/22 (0%)
EGF_CA 2011..2043 CDD:214542 9/31 (29%)
EGF_CA 2051..2092 CDD:214542 20/49 (41%)
TB 2108..2149 CDD:307020 11/67 (16%)
EGF_CA 2165..2205 CDD:328759 8/41 (20%)
EGF_CA 2207..2246 CDD:214542 7/39 (18%)
EGF_CA 2247..>2277 CDD:214542 9/46 (20%)
EGF_CA 2288..2330 CDD:328759
EGF_CA 2332..2372 CDD:311536
TB <2403..2430 CDD:307020
EGF_CA 2443..2484 CDD:214542
EGF_CA 2485..2524 CDD:328759
EGF_CA 2526..>2557 CDD:328759
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4721at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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