DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and fbn3

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_001120896.2	Gene:	fbn3 / 100151721	XenbaseID:	XB-GENE-1217676	Length:	2867	Species:	Xenopus tropicalis

Alignment Length:	1784	Identity:	449/1784 - (25%)
Similarity:	608/1784 - (34%)	Gaps:	649/1784 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 DGADSKPEPQIVIEINDDHANEVVESEPALAETETENEVLENETPLKAEVQTDVLNSSNASVKVT 235
            :|..|.|..|..|:|::...|.|:........||...:.:                 .||..:.|
Frog   518 EGYQSNPTKQACIDIDECIMNGVMCRNGRCVNTEGSFQCI-----------------CNAGFETT 565

  Fly   236 NDPYEPTFLDNNCGEDNGGCA--HICKRLLYPDENQPINKCDCREGYTLDPNDYASCLDIDEC-- 296
            .|       ..|| .|:..||  ::|...:..:|:... ||.|:.|:.|.||. ..|:|:|||
Frog   566 PD-------GKNC-VDHDECATTNMCLNGMCINEDGSF-KCICKPGFVLAPNG-RYCVDVDECQT 620

  Fly   297 --LESNGGC-------------------------------------------------------- 303
              :..||.|
Frog   621 PGICMNGRCINTEGSFRCECLGGLTIGIDGRVCVDTHMRSTCYGAIKKGTCARPFPGAVTKSECC 685

  Fly   304 ----------------------------------------------SE-----ICENLPGEYKCS 317
                                                          ||     |||||.|.|:|.
Frog   686 CASPDHGFGEPCQPCPAKNSAEFQALCSSGIGITADGRDINECALNSEICPNGICENLRGSYRCI 750

  Fly   318 CQEGYYLDESGKSCVDINECA-NPELSSNCQGACENLPGSYRCVEP--------LEENPEITEVV 373
            |..||..|.|||:|||::||| |..|..|  |.|.|.||||.|..|        .|...:|.|..
Frog   751 CNLGYESDASGKNCVDVDECAVNRLLCDN--GLCRNTPGSYTCTCPKGYVFKIDSETCEDINECA 813

  Fly   374 ENP----------------------IEKTNEV------------------PVNVS---------- 388
            .||                      ::.|..:                  .||::
Frog   814 SNPCVNGVCRNNAGSFVCECSFGSKLDSTGTICVDSMKGTCWLNIQDGRCEVNINGATLKSECCA 878

  Fly   389 -------------ESQPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQ-KCENTIG 439
                         |..||   |..|:. ...|..|:|:|||||       ...||.. :|.||.|
Frog   879 TLGAAWGSPCERCEIDPA---CPRGYS-RKKGVACEDVNECEV-------FPGVCPNGRCVNTAG 932

  Fly   440 SFRCTCVEGYHLLEDQRSCA------------LDSCT---------------------------- 464
            ||:|.|.||..|....|:|.            .|.||
Frog   933 SFKCECPEGLTLDGSGRNCVDVRVEQCYMKWDEDECTAQLPGKYRMDMCCCSVGAAWGIDCEECP 997

  Fly   465 -------------------------------DLENPQLNRTRCAH-ECQDLPEGSYRCVCPKGYE 497
                                           |:...::..:.|.| .|:: ..||:||||..|:.
Frog   998 KPGSDEFKALCPRGPGFANRGDVLSGRPFYKDVNECKVFNSLCTHGTCRN-SIGSFRCVCDSGFA 1061

  Fly   498 LSEDQHSCL-VQESPCSTEKGVEKCSPGTCLASEDNT--SFSCICPTGYRSEAF---SCQDIDEC 556
            |..::.:|. :.|...|.    :.|..|||:    ||  ||.|.|..||.|...   :|.|||||
Frog  1062 LDAEERNCTDIDECRISP----DLCGHGTCV----NTPGSFDCECFDGYESGFMMMKNCMDIDEC 1118

  Fly   557 AEDTHLC-SHTCQNTPGGYQCQCPEGLNLVEE-YTCLAENLCEVNNNGCEQ-ICLTARGGV-CAC 617
            ..|..|| ..||.||.|.::|.||.|..|..| ..|:..|.|.:::|.|.. .|:...|.. |:|
Frog  1119 ERDPLLCRGGTCINTDGSFECICPPGHELTSEGNACVDINECSLSDNLCRNGRCINMIGTYQCSC 1183

  Fly   618 REGFRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGIRGYCFDIDECSQ 682
            ..||:.:.|.:.|.|:|||.:.||||...|.|..|||.|.|:.||.|:.   .:..|.|||||..
Frog  1184 DSGFQSTPDRQGCVDIDECTIMNGGCDTHCTNSEGSYECSCSEGYALMP---DQRSCADIDECED 1245

  Fly   683 RTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLN------------------SSFI---- 725
            ....| |...|.|:.|.|.|||..|:...||......:|                  .|||
Frog  1246 NPDIC-DGGQCTNIPGEYRCLCFDGFMASLDMKTCIDVNECDLNPNICLHGECENTKGSFICHCQ 1309

  Fly   726 ------------TDSTSSETPSAH----------------------------TCLDIDECSLANG 750
                        ||....|. .||                            .|:|:|||:..:.
Frog  1310 LGYFVKKGTTGCTDIDECEV-GAHNCDVHASCLNVPGSFKCQCQTGWVGDGLNCVDLDECTTEDH 1373

  Fly   751 NC--SHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQ-LCLNQPGGFACACETGF 812
            .|  :..|.|.||.::|||..|:  :.|...|.|:|||.|:...|.. .|||.|||:.|.||.||
Frog  1374 KCNANANCVNTPGSYRCACNEGF--NGDGFICSDVDECADNVNLCENGHCLNAPGGYRCECEMGF 1436

  Fly   813 ELTPDGFGCADIDECSQD----YGNCSDICINLLGTHACACERGYELAKDKLSCLDVDECA---- 869
            ..|.|...|.|||||:..    :|.|.    ||.|...|.|:.||||.:...:|.||:|||
Frog  1437 TPTEDSKACQDIDECTFQNICVFGTCQ----NLPGMFRCICDDGYELDRSGGNCTDVNECADPVN 1497

  Fly   870 ---GLLSGGCSHECINKAGTFECGCPLGYILNDDGRSCSPALVG-CPPGTQRSADG---C----- 922
               ||        |:|..|.:.|.||..:.||..|..|....|| |...||...||   |
Frog  1498 CINGL--------CVNTPGNYLCNCPQDFELNPTGVGCVDTRVGNCFLETQPRGDGGLSCSAEIG 1554

  Fly   923 -----APIECNPGYTLGSD-DKC---------------------------VDIDECQKQNGGC-S 953
                 |...|:.|...|:. :.|                           .||||||:..|.| .
Frog  1555 VGVTRASCCCSLGRAWGNPCEFCPFANSTEYKTLCPGGEGFRPNPITVILEDIDECQELPGLCQG 1619

  Fly   954 HRCSNTEGSFKCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEI 1018
            ..|.||.|||:|.||.||.|:.:.:.|:|||||......|..|||.|.:|.:.|..|  |...::
Frog  1620 GNCVNTFGSFQCECPAGYYLNEETRICEDIDECSAHIGICGPGTCYNTLGNYTCVCP--PEYMQV 1682

  Fly  1019 PTASSLPESPKIELKTPKYPDFTELSNEIPENP---------------KKPAEFDYPEPKFPSLP 1068
            ...::..:..| .:....|.|..|  ||:..|.               .||.|   |.|. |:.|
Frog  1683 NGGNNCMDMRK-SVCYRNYNDTCE--NELSSNMTKKMCCCSYNIGKAWNKPCE---PCPS-PATP 1740

  Fly  1069 KWEGL-----PKLPPLADIPTSKAPVPLR--PEVP----KSLWVNQLQP-RDLCPRFQAPRN--- 1118
            ::..|     |..  :.||.|.| |:.:.  .|:|    ..:.:||:.. |..||...:..|
Frog  1741 EYIFLCGNQAPGF--IIDIRTGK-PMDIDECSEIPAICSNGVCINQIGSFRCECPMGFSYNNILL 1802

  Fly  1119 ----------GKSHCNRYRHKQKLFYYSRCRISCNSGYIL-------------QGPEIKS---C- 1156
                      |::.|.|......:....||  .|:|||.|             :.|.:.|   |
Frog  1803 ICEDIDECSSGENLCQRNADCINIPGSYRC--ECSSGYKLSPSGACVGRNECQEIPNVCSHGTCM 1865

  Fly  1157 DANGIW----------EGPETKCVAINQPRAQ--SPGICPALKPAQNGVILPA-------SC--- 1199
            |..|.:          .|.:|.|:.|::...|  ..|.|.....:.|.:..|.       .|
Frog  1866 DTEGSYICVCHNGFKASGDQTMCMDIDECDRQPCGNGTCKNTVGSYNCLCFPGFELTHNNDCMDI 1930

  Fly  1200 TQGPSRFGDVCRL-QCNAGFVSTGSLLTACMMLQGWSFGAD-LNCQPFGNGLLGNQLSPMWNSPK 1262
            .:..|..|.|||. ||   ..:.||.  .|:..:|:....| .||...      |:.:.:   |.
Frog  1931 DECYSLVGQVCRNGQC---INNVGSF--QCLCQEGYEITPDGKNCMDI------NECTSL---PG 1981

  Fly  1263 TVTPHQIQNVEQIRPYINCP-------ENVVILLHAGEQKAHVTLQRPQTNVKNGRLVAHPAWAG 1320
            |.:|...||:|.....| ||       :|.:.:....|: .::.|....||.           .|
Frog  1982 TCSPGTCQNLEGSFRCI-CPPGFEVQNDNCIDINECDEE-PNICLFGTCTNT-----------PG 2033

  Fly  1321 QLQGHLPAGVHKVDFRVNDPETKLTIKCHTIITVKAATPRESNPFTLFRISDYSRSSLPRPAPFA 1385
            ..|...|.|                                      |.:||..|         .
Frog  2034 SFQCVCPPG--------------------------------------FVLSDNGR---------R 2051

  Fly  1386 TLSTGSSFSFPAF-KALDATPKPVSFTKFQV----FPDSESSEHSKL----GSSSFFRLEPLFHE 1441
            ...|..||.|..| ....:.||..:.||.:.    .|.....:..:|    ||.:|..|.|..|.
Frog  2052 CFDTRQSFCFTRFDNGKCSVPKAFNTTKARCCCSKMPGEGWGDPCELCPQEGSVAFQELCPYGHG 2116

  Fly  1442 SSKLISAAPASSENTRVDLG--SDTSNYC 1468
            |      .|...: ||.|:.  |::...|
Frog  2117 S------IPGMGD-TREDVNECSESPGIC 2138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	21/145 (14%)
		cEGF	396..415	CDD:289433	5/18 (28%)
		FXa_inhibition	425..458	CDD:291342	14/33 (42%)
		FXa_inhibition	476..505	CDD:291342	11/29 (38%)
		vWFA	<550..586	CDD:294047	19/36 (53%)
		FXa_inhibition	596..630	CDD:291342	10/35 (29%)
		FXa_inhibition	636..>664	CDD:291342	14/27 (52%)
		EGF_CA	676..715	CDD:284955	17/38 (45%)
		FXa_inhibition	745..780	CDD:291342	11/36 (31%)
		FXa_inhibition	786..821	CDD:291342	16/35 (46%)
		FXa_inhibition	827..862	CDD:291342	12/38 (32%)
		FXa_inhibition	874..904	CDD:291342	9/29 (31%)
		FXa_inhibition	945..980	CDD:291342	16/35 (46%)
		CCP	1110..1170	CDD:153056	20/99 (20%)
		CCP	1183..1235	CDD:153056	15/62 (24%)
		DUF5011	1468..1536	CDD:295940	1/1 (100%)
fbn3	NP_001120896.2	Fibrillin_U_N	49..85	CDD:375622
		TB	197..>231	CDD:366245
		EGF_CA	249..>279	CDD:214542
		EGF_CA	291..331	CDD:311536
		TB	347..390	CDD:366245
		EGF_CA	491..525	CDD:214542	2/6 (33%)
		EGF_CA	531..572	CDD:214542	11/65 (17%)
		EGF_CA	573..613	CDD:214542	12/41 (29%)
		EGF_CA	614..647	CDD:214542	7/32 (22%)
		TB	670..712	CDD:366245	0/41 (0%)
		EGF_CA	724..765	CDD:214542	17/40 (43%)
		vWFA	<761..805	CDD:381780	20/45 (44%)
		TB	862..>895	CDD:366245	3/32 (9%)
		EGF_CA	911..951	CDD:389777	20/46 (43%)
		TB	967..1009	CDD:366245	2/41 (5%)
		EGF_CA	1071..1105	CDD:214542	14/41 (34%)
		EGF_CA	1114..1146	CDD:214542	17/31 (55%)
		EGF_CA	1156..1189	CDD:214542	10/32 (31%)
		FXa_inhibition	1202..1237	CDD:373209	15/37 (41%)
		EGF_3	1327..1362	CDD:372403	3/35 (9%)
		EGF_3	1368..1403	CDD:372403	11/36 (31%)
		EGF_CA	1405..1445	CDD:389777	19/39 (49%)
		EGF_CA	1447..1487	CDD:214542	16/43 (37%)
		TB	1549..1590	CDD:366245	6/40 (15%)
		EGF_CA	1606..1638	CDD:214542	18/31 (58%)
		cEGF	1628..1651	CDD:372248	11/22 (50%)
		TB	1703..1747	CDD:366245	12/49 (24%)
		EGF_CA	1764..1796	CDD:214542	7/31 (23%)
		EGF_CA	1806..>1838	CDD:214542	7/33 (21%)
		vWFA	<1846..1885	CDD:381780	6/38 (16%)
		EGF_CA	1890..1924	CDD:214542	6/33 (18%)
		EGF_CA	1929..1970	CDD:311536	12/45 (27%)
		EGF_CA	1972..2004	CDD:214542	10/41 (24%)
		EGF_CA	2012..2052	CDD:214542	12/98 (12%)
		TB	2069..2112	CDD:366245	10/42 (24%)
		EGF_CA	2127..2168	CDD:214542	3/12 (25%)
		EGF_CA	2169..2208	CDD:214542
		EGF_CA	2209..2241	CDD:238011
		EGF_CA	2249..2291	CDD:389777
		TB	2353..2393	CDD:366245
		EGF_CA	2404..2445	CDD:214542
		vWFA	<2444..2484	CDD:381780
		vWFA	<2482..2518	CDD:381780
		cEGF	2549..2572	CDD:372248
		EGF_CA	2569..>2598	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11717
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4721at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47507
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010