DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment frac and egf

DIOPT Version :9

Sequence 1:	NP_001137905.1	Gene:	frac / 38850	FlyBaseID:	FBgn0035798	Length:	1618	Species:	Drosophila melanogaster
Sequence 2:	NP_001106478.1	Gene:	egf / 100127663	XenbaseID:	XB-GENE-951823	Length:	1051	Species:	Xenopus tropicalis

Alignment Length:	852	Identity:	192/852 - (22%)
Similarity:	277/852 - (32%)	Gaps:	304/852 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 RLLYPDENQPINKCDCREGYTLDPNDYASCLDIDECLESNGGCSEICENLPGEYKCSCQEGYYLD 325
            :::||..:..|......:|             ...|..||..|::.||......||.|..|:.|.
Frog   301 KVVYPVRSYSIPNSSSNQG-------------AKSCSISNKHCTKTCEIDAENQKCHCMNGFVLS 352

  Fly   326 ESGKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEITEVVENPIEKTNEVPVNVSES 390
            .:|:.|.||||||  ..:..|...|||:||||.|
Frog   353 SNGRYCEDINECA--LWNHGCTLGCENIPGSYFC------------------------------- 384

  Fly   391 QPAGKTCNSGFQLSADGTDCQDINECEVDGPEDLDNNAVCQQKCENTIGSFRCTCVEGYHLLEDQ 455
                 ||..|:.|..|...|.|...|       |..:..|...|..|.....|||.||..|.||.
Frog   385 -----TCPEGYVLLPDNKTCHDKTPC-------LTEHIECSHGCVQTTKGPLCTCPEGSVLSEDG 437

  Fly   456 RSCALDSCTDLENPQLNRTRCAHECQDLPEGSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEK 520
            :||.  .||..:|     ..|:|.|.....|::.|.|..||.|..|:..||. ..|
Frog   438 KSCT--GCTSPDN-----GGCSHICIMSGPGTWECDCFPGYNLQLDRKQCLA-SGP--------- 485

  Fly   521 CSPGTCLASE--------DNTSFSCICPTGYRSEAFSCQDIDECAEDTHLCSHTCQNTPGGYQCQ 577
             .|....|:.        |.|::..:..:.. ...|:. |.|. .||....:||.        .:
Frog   486 -RPYLMFANVHDIRRINFDGTNYESVLDSQI-GRVFAL-DYDP-VEDRMYFAHTA--------LK 538

  Fly   578 CPEGLNLVEEYTCLAENLCEVNNNGCEQICLTARGGVCACREGFRLSA---------DGKSCEDV 633
            |.|..|:                :|.::..:.:  |..:..||..:.|         .||||.:.
Frog   539 CIESANM----------------DGSDRKKMIS--GDLSTLEGLTVDAINRKLYWTDRGKSCIER 585

  Fly   634 DECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGI--RGYCFDIDECSQR---TH-GCSDQML 692
            .:              |.|.|..|      |::.:.|  ||.|  :...:::   || |.:.::.
Frog   586 SD--------------LNGKYRKI------LIQENNIQPRGIC--VHPLAKKLFWTHVGANPRIE 628

  Fly   693 CENLNG-------SYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETPSAHTCLDIDECSLANG 750
            ..:|.|       |...:.|.|..:   :|:...:   :..|:..|.         |:..:|...
Frog   629 SSDLEGSEREVIISKDLIWPSGITV---DHLTDVI---YWCDAKKSV---------IESANLDGS 678

  Fly   751 NCSHFCQNEPGGFQCACPLGYALSEDMRTCQD-IDECL--------------------------- 787
            |...|.||:.|.     |...::.||.....| :...|
Frog   679 NRQSFSQNDVGH-----PFAISVFEDHLWVSDWVQPSLIRIEKRNTQNWVRLRGNMQRPSSVVIV 738

  Fly   788 -------------------DSNGQCSQLCLNQPGGFACA-CETGFELTP-------------DGF 819
                               |||.|.:......||..:.: .|.|....|             |..
Frog   739 HPLAKPVIADDIPLPRKEKDSNNQTAHSESFFPGPLSTSNAEMGTREAPSSRNGLLAEIMVSDDS 803

  Fly   820 GCADIDECSQDYGNCSDI---CINLLGTHACACERGYELAKDKLSCLDVDECAGLLSGGCSH--E 879
            ||.||        :| ||   |::......|.|..|: ....:| |.|:|||:..::....|  |
Frog   804 GCIDI--------HC-DINAHCVSSEDGPKCQCLEGF-TGNGRL-CHDIDECSLHIAACNPHQTE 857

  Fly   880 CINKAGTFECGCPLGYILNDDGRSCSPALVGCPPGTQRSADGCAPIECNPGYTLGSDDKCVDIDE 944
            ||:..|.:.|.|..|||                                     |:..:|.||||
Frog   858 CIDTEGGYICKCKYGYI-------------------------------------GNGLQCTDIDE 885

  Fly   945 CQKQNGGCSHR--CSNTEGSFKCSCP---PGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGG 1004
            |.:....|...  |:||||::.|:|.   ||...|...||.  |.||    .....|.|:|  ||
Frog   886 CSRGTHTCGENAVCTNTEGNYTCTCTNGFPGSAADCTGKTI--IREC----PLAYDGYCLN--GG 942

  Fly  1005 FRCEFPK 1011
            ....||:
Frog   943 VCIHFPE 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frac	NP_001137905.1	FXa_inhibition	296..331	CDD:291342	12/34 (35%)
		cEGF	396..415	CDD:289433	7/18 (39%)
		FXa_inhibition	425..458	CDD:291342	11/32 (34%)
		FXa_inhibition	476..505	CDD:291342	10/28 (36%)
		vWFA	<550..586	CDD:294047	9/35 (26%)
		FXa_inhibition	596..630	CDD:291342	7/42 (17%)
		FXa_inhibition	636..>664	CDD:291342	4/27 (15%)
		EGF_CA	676..715	CDD:284955	8/49 (16%)
		FXa_inhibition	745..780	CDD:291342	9/34 (26%)
		FXa_inhibition	786..821	CDD:291342	11/94 (12%)
		FXa_inhibition	827..862	CDD:291342	8/37 (22%)
		FXa_inhibition	874..904	CDD:291342	10/31 (32%)
		FXa_inhibition	945..980	CDD:291342	13/39 (33%)
		CCP	1110..1170	CDD:153056
		CCP	1183..1235	CDD:153056
		DUF5011	1468..1536	CDD:295940
egf	NP_001106478.1	LY	152..194	CDD:214531
		vWFA	<346..398	CDD:320736	24/89 (27%)
		FXa_inhibition	412..440	CDD:317114	11/27 (41%)
		FXa_inhibition	447..480	CDD:317114	11/37 (30%)
		LY	508..550	CDD:214531	11/68 (16%)
		LY	554..593	CDD:214531	10/54 (19%)
		Ldl_recept_b	615..654	CDD:278487	8/41 (20%)
		LY	638..680	CDD:214531	8/56 (14%)
		EGF_3	810..838	CDD:315598	8/30 (27%)
		EGF_3	851..880	CDD:315598	11/65 (17%)
		EGF_3	886..>914	CDD:315598	9/27 (33%)
		PHA02887	<927..>967	CDD:333467	10/29 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000