DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32374 and PRSS53

DIOPT Version :9

Sequence 1:	NP_729270.1	Gene:	CG32374 / 38848	FlyBaseID:	FBgn0052374	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	293	Identity:	64/293 - (21%)
Similarity:	98/293 - (33%)	Gaps:	110/293 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 PYQCALHYNNYFICGCVILNRRWILTAQHC--------------KIG-------NPGRYTVRAGS 129
            |:|.::......||...::...|:|||.||              .:|       :||...|...:
Human    49 PWQASVRRQGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAA 113

  Fly   130 TQQRRGGQLRHVQKTVCHPNYSEYTMKNDLCMMKL-----KTPLNVGRCVQKVKLPSTRTKRFP- 188
            .|..|.              |:.|:..:||.:::|     .|||    |     ||.. ..|||
Human   114 LQLPRA--------------YNHYSQGSDLALLQLAHPTTHTPL----C-----LPQP-AHRFPF 154

  Fly   189 --KCYLASGWGLTSANAQNVQRYLRGVIVC----KVSRAKC------------------------ 223
              .|: |:||...:::.:...|...|..:|    .||...|
Human   155 GASCW-ATGWDQDTSDGKCWPRLKLGEALCLPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAP 218

  Fly   224 --------QQDYRGTGIKIYKQ-------------MICAKRKN--RDTCSGDSGGPLV-----HN 260
                    :...|.|...||.|             |:|...:.  :..|.||||||::     .:
Human   219 GTLRNLRLRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGH 283

  Fly   261 GVLYGITSFGIGCASAKYPGVYVNVLQYTRWIK 293
            .|..||.||...||....|.:..|...::.|::
Human   284 WVQAGIISFASSCAQEDAPVLLTNTAAHSSWLQ 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32374	NP_729270.1	Tryp_SPc	73..292	CDD:214473	63/290 (22%)
CG32374	NP_729270.1	Tryp_SPc	74..295	CDD:238113	64/293 (22%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	64/291 (22%)
		Tryp_SPc	43..314	CDD:214473	63/289 (22%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149426
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030