DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16998 and PRSS1

DIOPT Version :9

Sequence 1:	NP_648134.1	Gene:	CG16998 / 38847	FlyBaseID:	FBgn0035795	Length:	258	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	254	Identity:	85/254 - (33%)
Similarity:	124/254 - (48%)	Gaps:	19/254 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNILALILLLICGHKTSALSPQERIVGGVEVPIHLTPWLASITVHGNYSCSSALITSLWLVTAGH 65
            ||.| |||..:.....:.....::||||.....:..|:..|:. .|.:.|..:||...|:|:|||
Human   226 MNPL-LILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLN-SGYHFCGGSLINEQWVVSAGH 288

  Fly    66 CVQYPDSYSVRAGS---TFTDGGGQRRNVVSVILHPDFNLRTLENDIALLKLDKSFTLGGNIQVV 127
            |  |.....||.|.   ...:|..|..|...:|.||.::.:||.|||.|:||.....:...:..:
Human   289 C--YKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTI 351

  Fly   128 KLPLPSLNILPRT---LLVAGWGNPDATDSESEPRLRGTVVKVINQRLCQRLYSHLHRPITDDMV 189
            .||...    |.|   .|::||||..::.::....|:.....|::|..|:..|.   ..||.:|.
Human   352 SLPTAP----PATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYP---GKITSNMF 409

  Fly   190 CAA--GAGRDHCYGDSGAPLVHRGSSYGIVSFAHGCADPHFPGVYTRLANYVTWIFNVL 246
            |..  ..|:|.|.||||.|:|..|...|:||:..|||..:.|||||::.|||.||.|.:
Human   410 CVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTI 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16998	NP_648134.1	Tryp_SPc	24..242	CDD:214473	76/225 (34%)
CG16998	NP_648134.1	Tryp_SPc	25..242	CDD:238113	76/224 (34%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	76/225 (34%)
		Tryp_SPc	249..467	CDD:238113	78/227 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810