DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG16998 and PRSS53

DIOPT Version :9

Sequence 1:	NP_648134.1	Gene:	CG16998 / 38847	FlyBaseID:	FBgn0035795	Length:	258	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	299	Identity:	77/299 - (25%)
Similarity:	121/299 - (40%)	Gaps:	79/299 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CGHK-TSALSPQERIVGGVEVPIHLTPWLASITVHGNYSCSSALITSLWLVTAGHCVQYP----- 70
            ||.: .....|||    |..||.. .||.||:...|.:.||.:|:...|::||.||.:..
Human    28 CGQRGPGPPKPQE----GNTVPGE-WPWQASVRRQGAHICSGSLVADTWVLTAAHCFEKAAATEL 87

  Fly    71 DSYSVRAGSTFTDG---GGQRRNVVSVILHPDFNLRTLENDIALLKL--------------DKSF 118
            :|:||..||...:|   |.:...|.::.|...:|..:..:|:|||:|              ...|
Human    88 NSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQGSDLALLQLAHPTTHTPLCLPQPAHRF 152

  Fly   119 TLGGNIQVV-------------------KLPLPSLNI------------LPRTLLVAGWGNPDAT 152
            ..|.:....                   .|.|||:.:            |||:..:|    |..:
Human   153 PFGASCWATGWDQDTSDGKCWPRLKLGEALCLPSVTVSAPNCPGFQSPLLPRSQTLA----PAPS 213

  Fly   153 DSESEPRLRGTVVKVINQRLCQRLYSHLHR-----PITDDMVCAA---GAGRDHCYGDSGAPLV- 208
            .|.:...||...:::|::..|..:|:.||:     |....|:|..   |. :..|.||||.|::
Human   214 LSPAPGTLRNLRLRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGV-QGPCQGDSGGPVLC 277

  Fly   209 -----HRGSSYGIVSFAHGCADPHFPGVYTRLANYVTWI 242
                 |...: ||:|||..||....|.:.|..|.:.:|:
Human   278 LEPDGHWVQA-GIISFASSCAQEDAPVLLTNTAAHSSWL 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16998	NP_648134.1	Tryp_SPc	24..242	CDD:214473	71/284 (25%)
CG16998	NP_648134.1	Tryp_SPc	25..242	CDD:238113	71/283 (25%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	71/281 (25%)
		Tryp_SPc	43..314	CDD:214473	70/277 (25%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100