DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG16998 and F12

DIOPT Version :9

Sequence 1:NP_648134.1 Gene:CG16998 / 38847 FlyBaseID:FBgn0035795 Length:258 Species:Drosophila melanogaster
Sequence 2:NP_000496.2 Gene:F12 / 2161 HGNCID:3530 Length:615 Species:Homo sapiens


Alignment Length:262 Identity:84/262 - (32%)
Similarity:121/262 - (46%) Gaps:38/262 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LICGHK-TSALSPQERIVGGVEVPIHLTPWLASITVHGNYSCSSALITSLWLVTAGHCVQ---YP 70
            |.||.: ..:||...|:|||:.......|::|:: ..|:..|:.:||...|::||.||:|   .|
Human   357 LSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAAL-YWGHSFCAGSLIAPCWVLTAAHCLQDRPAP 420

  Fly    71 DSYSVRAGSTFTDGGGQRRN----------VVSVILHPDFNLRTLENDIALLKLDKS-----FTL 120
            :..:|..|.       :|||          |.|..||..|:..:.::|:|||:|.:.     ..|
Human   421 EDLTVVLGQ-------ERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALL 478

  Fly   121 GGNIQVVKLPLPSLNILPRTLL-VAGWGNPDATDSESEPRLRGTVVKVINQRLCQRLYSHLHRPI 184
            ...:|.|.||..:......||. |||||:......|....|:...|..::...|.....| ...|
Human   479 SPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVH-GSSI 542

  Fly   185 TDDMVCAA--GAGRDHCYGDSGAPLV-------HRGSSYGIVSFAHGCADPHFPGVYTRLANYVT 240
            ...|:||.  ..|.|.|.||||.|||       .|.:..||:|:..||.|.:.|||||.:|.|:.
Human   543 LPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLA 607

  Fly   241 WI 242
            ||
Human   608 WI 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG16998NP_648134.1 Tryp_SPc 24..242 CDD:214473 77/245 (31%)
Tryp_SPc 25..242 CDD:238113 76/244 (31%)
F12NP_000496.2 FN2 41..88 CDD:128373
EGF_CA 96..131 CDD:238011
FN1 133..173 CDD:238018
EGF 178..206 CDD:278437
Kringle 217..295 CDD:278480
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 298..359 1/1 (100%)
Tryp_SPc 372..609 CDD:214473 77/245 (31%)
Tryp_SPc 373..612 CDD:238113 78/246 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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