DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16998 and PRSS55

DIOPT Version :9

Sequence 1:	NP_648134.1	Gene:	CG16998 / 38847	FlyBaseID:	FBgn0035795	Length:	258	Species:	Drosophila melanogaster
Sequence 2:	NP_940866.2	Gene:	PRSS55 / 203074	HGNCID:	30824	Length:	352	Species:	Homo sapiens

Alignment Length:	260	Identity:	80/260 - (30%)
Similarity:	120/260 - (46%)	Gaps:	36/260 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 CGHKT--SALSPQERIVGGVEVPIHLTPWLASITVHGNYSCSSALITSLWLVTAGHCVQ----YP 70
            ||.::  ...:...||.||:|..:...||..||.......|..:::...|::||.||:.    :|
Human    53 CGDRSIFEGRTRYSRITGGMEAEVGEFPWQVSIQARSEPFCGGSILNKWWILTAAHCLYSEELFP 117

  Fly    71 DSYSVRAGST-FTDGGGQRRNVVSVILHPDFNLRTLENDIALLKLDKSFTLGGNIQVVKLPLPSL 134
            :..||..|:. .|....:.:.|.|:|||.||....::||||||.|.....|..    :|:|:
Human   118 EELSVVLGTNDLTSPSMEIKEVASIILHKDFKRANMDNDIALLLLASPIKLDD----LKVPI--- 175

  Fly   135 NILP--------RTLLVAGWGNPDATDSES-EPRLRGTVVKVINQRLCQRLYSHLHRPITDDMVC 190
             .||        |...|||||..:|.|..| :..|....:.:::...|.:::..|    |.:|:|
Human   176 -CLPTQPGPATWRECWVAGWGQTNAADKNSVKTDLMKAPMVIMDWEECSKMFPKL----TKNMLC 235

  Fly   191 AA--GAGRDHCYGDSGAPLV------HRGSSYGIVSFAHGCADPHFPGVYTRLANYVTWIFNVLE 247
            |.  ....|.|.||||.|||      .:....||:|:...|.:.:.||:||.|.||..||..|.:
Human   236 AGYKNESYDACKGDSGGPLVCTPEPGEKWYQVGIISWGKSCGEKNTPGIYTSLVNYNLWIEKVTQ 300

Fly 248 247
Human 301 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16998	NP_648134.1	Tryp_SPc	24..242	CDD:214473	75/239 (31%)
CG16998	NP_648134.1	Tryp_SPc	25..242	CDD:238113	74/238 (31%)
PRSS55	NP_940866.2	Tryp_SPc	67..295	CDD:214473	75/239 (31%)
		Tryp_SPc	68..298	CDD:238113	76/241 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910