DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment POTEC and Potea

DIOPT Version :9

Sequence 1:NP_001131143.1 Gene:POTEC / 388468 HGNCID:33894 Length:542 Species:Homo sapiens
Sequence 2:NP_001365522.1 Gene:Potea / 67575 MGIID:1914825 Length:2320 Species:Mus musculus


Alignment Length:396 Identity:131/396 - (33%)
Similarity:202/396 - (51%) Gaps:39/396 - (9%)


- Green bases have known domain annotations that are detailed below.


Human   130 EPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLRDTDMNKRDKQKRTALHLASANGNSEVVQLLLD 194
            ||||    :.|.|:|:||..|...|...::.|....::.||.::|||||.|.|.|..|||.:||.
Mouse    40 EPRY----KPLRKIHQAASDGDTERLQRMISLGKHSVHDRDFKERTALHFACACGQVEVVSILLR 100

Human   195 RRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADQNIPDEYGNTTLHYAVHNEDKLMAKALL 259
            ..|.::..|....|.|:||||....|||.:||:||||.|..|:.|||:|||||..:::.:||.||
Mouse   101 NNCDIDAADMNFITPLMKAVQNWTYECVCILLKHGADPNRKDKNGNTSLHYAVSEDNQTLAKCLL 165

Human   260 LYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVNLL 324
            .|.|::|.|||.|.|||||.:.|.|.::.|||:|..||::..|...|..|:.|:...|..:||||
Mouse   166 KYSANMEQKNKDGFTPLLLALKENKIEMAKFLVKMGANIHVFDDMRRNTLLYAIRWDSKDMVNLL 230

Human   325 LEQNVDVSSQDLSGQTAREYAVSSHHHVICELLSDYKEKQMLKISSENSNPEQDLKLTSEEESQR 389
            |::.:|...:|:.|.||..||:........|:|.:|.|  ||:..:::..||...     .|.:.
Mouse   231 LDEGIDFFFRDVFGWTALRYAIEGTSKGSREILMNYDE--MLRRKNKDGIPEYKF-----FEDKS 288

Human   390 LKVSENSQPEKMSQEPEINKD-CDREVEEEIKKHGSNPVGLPENLTNGASAGNGDDGLIPQRRSR 453
            |....|: |...|..|:.|:: |..:.|.:|.|:   .:|...|..:||    |::|        
Mouse   289 LDKHPNN-PTSGSTFPKSNENACKFDDELDISKY---VLGTCPNNIHGA----GEEG-------- 337

Human   454 KPENQQFPDTENEEYHSDEQ---NDTRKQLSEEQNTGISQDEILTNKQKQIEVAEKKMNSELSLS 515
                    |....:..:|.|   |.|.|..::.:...:::...:|.....|:.::.::.|.:...
Mouse   338 --------DKSETKKAADVQVWTNPTLKSSTKGKVPNLNEVGTMTESHHFIKESDLEIESLVETF 394

Human   516 HKKEED 521
            ....||
Mouse   395 SYDNED 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POTECNP_001131143.1 ANK 1 138..171 9/32 (28%)
Ank_4 143..193 CDD:290365 19/49 (39%)
ANK 167..292 CDD:238125 62/124 (50%)
ANK 2 172..201 14/28 (50%)
ANK repeat 174..203 CDD:293786 14/28 (50%)
Ank_2 177..269 CDD:289560 44/91 (48%)
ANK repeat 205..236 CDD:293786 16/30 (53%)
ANK 3 205..234 15/28 (54%)
ANK 233..357 CDD:238125 52/123 (42%)
ANK repeat 238..269 CDD:293786 15/30 (50%)
ANK 4 238..267 14/28 (50%)
Ank_2 243..335 CDD:289560 40/91 (44%)
ANK repeat 271..302 CDD:293786 14/30 (47%)
ANK 5 271..300 14/28 (50%)
ANK repeat 304..335 CDD:293786 10/30 (33%)
ANK 6 304..333 10/28 (36%)
ANK 7 337..373 11/35 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..494 25/128 (20%)
PoteaNP_001365522.1 ANK repeat 49..76 CDD:293786 6/26 (23%)
Ank_2 65..>252 CDD:423045 83/186 (45%)
ANK repeat 80..109 CDD:293786 14/28 (50%)
ANK repeat 114..142 CDD:293786 16/27 (59%)
ANK repeat 144..175 CDD:293786 15/30 (50%)
ANK repeat 177..208 CDD:293786 14/30 (47%)
ANK repeat 210..235 CDD:293786 9/24 (38%)
Smc <1772..1994 CDD:224117
DUF3496 1956..2060 CDD:403277
DUF3496 2181..2284 CDD:403277
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
HGNC 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 196 1.000 Inparanoid score I16278
Isobase 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1514637at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24118
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
66.030

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