DRSC/TRiP Functional Genomics Resources

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Protein Alignment POTEC and acta1a

DIOPT Version :9

Sequence 1:NP_001131143.1 Gene:POTEC / 388468 HGNCID:33894 Length:542 Species:Homo sapiens
Sequence 2:NP_001017750.1 Gene:acta1a / 550445 ZFINID:ZDB-GENE-050417-267 Length:377 Species:Danio rerio


Alignment Length:302 Identity:59/302 - (19%)
Similarity:105/302 - (34%) Gaps:90/302 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    34 CCKGSGKSNMGTSGDHDDSFMKMLRSKMGKCCHHCFPCCRGSGTSNVGTSGDHDNSFMKTLRSKM 98
            |..|||....|.:|  ||:...:..|.:|:..|.......|...|.||.........: ||:   
Zfish    12 CDNGSGLVKAGFAG--DDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGIL-TLK--- 70

Human    99 GKWCCHCFPCCRGSGKSNVGAWGDYDDSAFMEPRYHVRREDLDKLHRAAWWG--KVPRKDLIVML 161
                   :|...|.    :..|                 :|::|:....::.  :|..::...:|
Zfish    71 -------YPIEHGI----ITNW-----------------DDMEKIWHHTFYNELRVAPEEHPTLL 107

Human   162 RDTDMN-KRDKQKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLML 225
            .:..:| |.:::|.|              |::.:   ..||      .|:..|:|     .||.|
Zfish   108 TEAPLNPKANREKMT--------------QIMFE---TFNV------PAMYVAIQ-----AVLSL 144

Human   226 LEHGADQNIPDEYGNTTLHYAVHNEDKLMAKALL---LYGADIESKNKCGLTPLLLGVHEQK--- 284
            ...|....|..:.|:...|.....|...:..|::   |.|.|        ||..|:.:..::   
Zfish   145 YASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRD--------LTDYLMKILTERGYS 201

Human   285 ------QQVVKFLIKKKANLNALDRYGRTALILAVCCGSASI 320
                  :::|:. ||:|....|||....    :|....|:|:
Zfish   202 FVTTAEREIVRD-IKEKLCYVALDFENE----MATAASSSSL 238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POTECNP_001131143.1 ANK 1 138..171 6/35 (17%)
Ank_4 143..193 CDD:290365 7/52 (13%)
ANK 167..292 CDD:238125 26/137 (19%)
ANK 2 172..201 3/28 (11%)
ANK repeat 174..203 CDD:293786 4/28 (14%)
Ank_2 177..269 CDD:289560 18/94 (19%)
ANK repeat 205..236 CDD:293786 8/30 (27%)
ANK 3 205..234 7/28 (25%)
ANK 233..357 CDD:238125 21/100 (21%)
ANK repeat 238..269 CDD:293786 7/33 (21%)
ANK 4 238..267 7/31 (23%)
Ank_2 243..335 CDD:289560 19/90 (21%)
ANK repeat 271..302 CDD:293786 8/39 (21%)
ANK 5 271..300 7/37 (19%)
ANK repeat 304..335 CDD:293786 3/17 (18%)
ANK 6 304..333 3/17 (18%)
ANK 7 337..373
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..494
acta1aNP_001017750.1 NBD_sugar-kinase_HSP70_actin 4..377 CDD:302596 59/302 (20%)
ACTIN 7..377 CDD:214592 59/302 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5277
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100127
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.710

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