DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lqf and epn3a

DIOPT Version :9

Sequence 1:	NP_729266.2	Gene:	lqf / 38846	FlyBaseID:	FBgn0028582	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_009298027.1	Gene:	epn3a / 794862	ZFINID:	ZDB-GENE-131121-324	Length:	645	Species:	Danio rerio

Alignment Length:	767	Identity:	264/767 - (34%)
Similarity:	361/767 - (47%)	Gaps:	217/767 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VNVAGLRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLN 74
            :..:.|||.:||:.:||:||::|||||||||||||.:::|.||::||:|||||:|:|.:||||||
Zfish     1 MTTSSLRRQVKNIVNNYTDAEIKVREATSNDPWGPPSSLMMEISDLTFNVVAFTEVMGIIWKRLN 65

  Fly    75 DHGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFE-EGKDQGTHVREKAKQL 138
            |||||||||||||.|||||||||||:|||||||||:||||||:|.|.: :|:|||..||||:|||
Zfish    66 DHGKNWRHVYKALNLLEYLIKTGSERVAQQCKENIYAIQTLRDFQYIDRDGQDQGMSVREKSKQL 130

  Fly   139 VTLLKDDERLKNERVKAQKAKERFAQNPS--GFGS-----DGYIDGPSQ--------------RD 182
            |.||:||||||.||.:|.|.:||...:.|  |:||     .|  ..|||              ||
Zfish   131 VALLRDDERLKQERSQAHKTRERVTGSTSAMGYGSLPPPYPG--RHPSQPSMQAVHVDEFARPRD 193

  Fly   183 LPPGW--QEEPPKSVSELEMVRPQTAGEEELQLQLAMAMSREEAEQEE---------AKRRSDDV 236
            .|..:  ....|....:||..||||:||||||||||:||||||:|:..         |....:..
Zfish   194 SPASFNSSSSSPHLAPDLERARPQTSGEEELQLQLALAMSREESEKTHESVLPQPTPAVDIDEQT 258

  Fly   237 RLQLALSQSEQDFKDPNGRPIPAP----------------------KKEEQQSHLLDLLDISL-- 277
            :||:|:|.|:::...|...|.|.|                      |:|.||.......|.||
Zfish   259 QLQIAMSLSKEETHKPTPLPPPPPPPAAAVMEMDEEAQLQLALTLSKEEHQQEERSRRGDESLLQ 323

  Fly   278 GATSISSPPLGAAGGAPTAVVDPWAMPGPRAPSQLSDPWSGTSSPQV----DPWNPSAAPRTILG 338
            .|...|...:.|.||  :|::|            |:|.:  ||:|::    ..|:.|.....:..
Zfish   324 KALEESKREMEAKGG--SAMLD------------LADIF--TSAPELPSAASAWDSSGGQGALAQ 372

  Fly   339 AGVPMTSAPLGAGNDAWGARTQSPSV-ASGSSNEGWLQSNGNANQNGRGATPAGPPAEGWLIKST 402
            || |:.|       |.|.:...|.|: ..|||   |     ||           |||....
Zfish   373 AG-PLRS-------DPWDSLEPSSSIRRHGSS---W-----NA-----------PPASSEY---- 406

  Fly   403 AVGALGAAPINHAANNGSSSSDPWLAEPAASA-----------AGGAAAVGLADPWAPGAASQTG 456
                  :.|..|.    ..:||||.|...||:           |.||.    .||::|....:.|
Zfish   407 ------SQPWAHR----QQTSDPWDAPQNASSPVSTNHTWISPAHGAG----VDPFSPPVVDRRG 457

  Fly   457 AGALDDPWKALGTGAIKKQSPEFDEFDLITNRNKSEHSNSNASNNNNASLLDD-MDPLSANYGNG 520
            :           .|.:|...|                   .|.:.::..|.|: ||...||....
Zfish   458 S-----------IGPLKTSPP-------------------RAGSPSDDDLFDEAMDGGQANVNGH 492

  Fly   521 G----IN-SSMHPSTGATAKKSIKDAHSFLGENSA-LVNLDNLIKPIAPQTQTGNQPAYNPFSDN 579
            |    .| ||:.......|.::.....:|||.:.| |||||:||.| .|.::.     :|||...
Zfish   493 GSPEPFNLSSLGEGLPKPAPRTCSTPEAFLGPSGASLVNLDSLIPP-NPTSKN-----FNPFLSG 551

  Fly   580 VVPPKT-NLFQQQQPAVPSINQLKQQA--------PFSVSMNQDPWAPVMGGVSTTSQPKLPPPV 635
            |..|.| |.||.:.|.: ::||::..:        ||:.|:          .::::.|
Zfish   552 VPAPTTSNPFQNEAPRL-TLNQMRPSSTSPAPSSLPFNASL----------AMASSQQ------- 598

  Fly   636 RPTSLNLGPSSVGEFQLLSALSNPIIPIAHIPQPQPNLQVYNNAYQSSSSTN 687
                    |||:......||...|:||   .|.|||.|.:.:....:...|:
Zfish   599 --------PSSLPNTFTQSAQVMPLIP---GPLPQPLLPLSSKTMLADPDTH 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqf	NP_729266.2	ENTH_epsin	28..149	CDD:239627	92/121 (76%)
lqf	NP_729266.2	UIM	208..227	CDD:197845	16/18 (89%)
epn3a	XP_009298027.1	ENTH_epsin	19..141	CDD:239627	92/121 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576793
Domainoid	1	1.000	213	1.000	Domainoid score	I2694
eggNOG	1	0.900	-	-		E1_KOG2056
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263849at2759
OrthoFinder	1	1.000	-	-		FOG0000780
OrthoInspector	1	1.000	-	-		otm24626
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12276
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2102
SonicParanoid	1	1.000	-	-		X540
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880