DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lqf and Enthd1

DIOPT Version :9

Sequence 1:	NP_729266.2	Gene:	lqf / 38846	FlyBaseID:	FBgn0028582	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001129385.1	Gene:	Enthd1 / 685900	RGDID:	1587874	Length:	616	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	169/621 - (27%)
Similarity:	257/621 - (41%)	Gaps:	156/621 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLNDHGKNW 80
            ||.:||...|||:|:.||||||||||||||:::|..|:::|:|..:.||||.|:|:||:||||||
  Rat     4 RRQVKNFVKNYSEAEKKVREATSNDPWGPSSSLMLAISDMTFNAASLSEIMHMLWQRLSDHGKNW 68

  Fly    81 RHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEE-GKDQGTHVREKAKQLVTLLKD 144
            |||||:|.|::||||.||.||.|.|:|.:..:|.|::|.:.:| |||||.::||::||::|||.|
  Rat    69 RHVYKSLALMDYLIKNGSRKVIQYCREGVCNLQMLKDFQHVDEAGKDQGRYIRERSKQVITLLMD 133

  Fly   145 DERLKNERVKAQKAKERFAQNPSGFGSDGYIDGPSQRDLP---PGWQEEPPKSVSELEMVRPQTA 206
            ::.|..||..|...::|.:.:.|               .|   |.....|....|.|
  Rat   134 EQLLYKEREVATWTRQRTSYSMS---------------FPKRLPAAGNSPAACASVL-------- 175

  Fly   207 GEEELQLQLAMAMSREEAEQEEAKR------RSDDVRLQLALSQSEQDFKDPNGRPIPAPKKEEQ 265
                    :..:::.|:...::.|:      :.:..:.:|.|.|. ||...|.|..:|
  Rat   176 --------IPESLTSEKRHSQDCKKTASLCGKKNTSKARLRLEQC-QDVPSPAGSSLP------- 224

  Fly   266 QSHLLDLLDISLGATSISS--------------PPLGAAGGAPTAVVDPWAMPGPRAPSQLSDPW 316
                  |...|||..:..|              |||                  ||.|..|:.|.
  Rat   225 ------LYFPSLGMKAWKSTEDLTLLYSYEQPKPPL------------------PRLPPPLTSPT 265

  Fly   317 SGTSSPQVDP---WNPSAAPRTILGAGVPMTSAPLGAGNDAWGARTQSPSVASGSSNEGWLQSNG 378
            |..|..:.:.   |:..|            .|.|          ..:|||:.:..|....|:
  Rat   266 SWLSEGEAEVCNLWDTEA------------VSTP----------PEKSPSMQTNMSLGKKLE--- 305

  Fly   379 NANQNGRGATPAGPPAEGWLIKSTAVGALG-AAPI--------------------NHAANNGSSS 422
            .|..|....:|...|.|    |.||.|:.. .||:                    :.:..:..||
  Rat   306 KAIANTITESPPHTPQE----KQTAAGSFDMPAPLQAFWPSGKDEFISLGLRMSKSESMFHNQSS 366

  Fly   423 SDPWLAEPAASAAG--GAAAVGLADPWAPGAASQTGAGALDDPWKALGTGAIKKQSPEFDEFDLI 485
            .:.....||..|..  ...:..|..| |..:..|...|.|..  .|:......||:   :|....
  Rat   367 VETLFVSPAFKAVSPLNKTSKDLQTP-AQRSICQMEDGNLKP--LAMWGECTPKQA---NETVST 425

  Fly   486 TNRNKSEHSNSNASNNNNA---SLLDDMDPLSANYGNGGINSSMHPSTGATAK-KSIKDAHSFLG 546
            |:...|..|..:.|:.::|   .......|:.|:.....:.....||...|.| ::::..|.|..
  Rat   426 TSEVTSSFSTLSVSSPDSAHPEKSAKRFTPVLASPSFWTLPQPQSPSVPFTYKTEAVRVCHPFAP 490

  Fly   547 ENSALVNLDNLIKPIAPQT--QTGNQPAYNPFSDNV 580
            ..:|  :.|:...|..|..  ....:|:|:|.||.|
  Rat   491 TGTA--SSDDEEYPSLPDNSDSAAKKPSYSPSSDRV 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqf	NP_729266.2	ENTH_epsin	28..149	CDD:239627	68/121 (56%)
lqf	NP_729266.2	UIM	208..227	CDD:197845	1/18 (6%)
Enthd1	NP_001129385.1	ENTH	14..137	CDD:279725	70/122 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337638
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2056
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263849at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12276
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850