Protein Alignment lqf and Epn2

DIOPT Version :10

• Sequence 1: NP_729266.2
• Gene: lqf / 38846
• FlyBaseID: FBgn0028582
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: XP_006246583.1
• Gene: Epn2 / 60443
• RGDID: 619773
• Length: 652
• Species: Rattus norvegicus
• Alignment Length: 766
• Identity: 276/766 - (36%)
• Similarity: 360/766 - (46%)
• Gaps: 258/766 - (33%)

  Fly    10 VNVAGLRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLN 74
            :..:.:||.:||:.:|||:|::||||||||||||||:::|:|||:||||||||||||.|:|||||
  Rat     1 MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLN 65

  Fly    75 DHGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFE-EGKDQGTHVREKAKQL 138
            |||||||||||||.||:||||||||:|||||:|||||||||::|.|.: :|||||.:||||:|||
  Rat    66 DHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQL 130

  Fly   139 VTLLKDDERLKNERVKAQKAKERFAQNPSGFGSD------------------------------- 172
            |.||||:||||.|||:|.|.|||.||..:|.||:
  Rat   131 VALLKDEERLKVERVQALKTKERMAQVATGVGSNQITFGRGSSQPNLSTSYSEQEYGKAGGSPAS 195

  Fly   173 ---------------GYIDGPSQRDLPPGWQEEP------------------------------P 192
                           |.:.|.|: :|.|..|..|                              |
  Rat   196 YHGSPEASLCPQHRTGAMLGQSE-ELQPLSQRHPCLPHLGLASHPNGDWAQPCLTCDRAARATSP 259

  Fly   193 KSVSELEMVRPQTAGEEELQLQLAMAMSREEAEQ------------EEAKRRSDDVRLQLALSQS 245
            :..||||..||||:||||||||||:|||||.|||            ||..||.||:|||:||.:|
  Rat   260 RVSSELEQARPQTSGEEELQLQLALAMSREVAEQSSESVQTARGSKEERLRRGDDLRLQMALEES 324

  Fly   246 EQD-FKDPNGRPIPA---PKKEEQQSHLLDLLDISLGATSISSPPLGAAGGAPTAVVDPWAMPGP 306
            .:| .|.|..:.:.|   |....||:.||||:|                           |:|..
  Rat   325 RRDTVKVPKKKEVKACCKPGSHSQQTTLLDLMD---------------------------ALPSS 362

  Fly   307 RAPSQLSDPWS-GTSSPQVDPWNPSAAPRTILGAGVPMTSAPLGAGNDAWGARTQSPSVASGSSN 370
            ...:|.::||| ||.:.|.:||..:.||..|               :|.|      ||.
  Rat   363 GPVAQKTEPWSTGTPANQTNPWGGTVAPANI---------------SDPW------PSF------ 400

  Fly   371 EGWLQSNGNANQNGRGATPAGPPAEGWLIKSTAVGALGAAPINHAANNGSSSSDPWLA--EPAAS 433
                           |..||. ..:.|.:.:||  ::.:.|.|         ||||.|  :||:.
  Rat   401 ---------------GTKPAA-SVDPWGVPTTA--SIQSVPKN---------SDPWAASQQPASD 438

  Fly   434 AAGGAAAVGLADPWAPGAASQTGAGALDDPWKALGTGAIKKQSPEFDEFDLITNRNKSEHSNSNA 498
            |...|.|.|.|.|     :..:|:..|...:    .|.:|   .:|.|||.:....|...|.::.
  Rat   439 AGKTADAWGAAKP-----SPASGSFELFSNF----NGTVK---DDFSEFDNLRTSKKPAESGASV 491

  Fly   499 ----SNNNNASLLDDMDPLSANYGNGGINSSMHPSTGATAKKSIKDAHSFLGENSALVNLDNLI- 558
                |...:..|.:.....||         |..||:..      |...||||.|:||||||:|:
  Rat   492 PPQDSRTTSPDLFESQSLTSA---------SSKPSSAR------KTPESFLGPNAALVNLDSLVT 541

  Fly   559 KPIAPQTQTGNQPA--YNPF--SDNVVPPKTNLFQQQQPAVPSINQLKQQAPFSVSMNQDPWAPV 619
            ||        |.||  .|||  .....|...|.||..||...::|||:             .:||
  Rat   542 KP--------NPPAQSLNPFLAPGAAAPAPVNPFQVNQPQPLTLNQLR-------------GSPV 585

  Fly   620 MG---------GVSTTS-QPKLPP------------PVRPTSLNLGPSSVG 648
            :|         ||.|.: .|.:.|            |:.||::|: ..|||
  Rat   586 LGSSASFGSGPGVETVAPMPSVAPHSALGATGSSLTPLGPTAMNM-VGSVG 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lqf	NP_729266.2	ENTH_Epsin	28..150	CDD:340787	96/122 (79%)
		UIM	208..227	CDD:197845	17/30 (57%)
		PHA03247	<278..394	CDD:223021	21/116 (18%)
Epn2	XP_006246583.1	ENTH_Epsin	19..141	CDD:340787	95/121 (79%)