DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lqf and lqfR

DIOPT Version :9

Sequence 1:	NP_729266.2	Gene:	lqf / 38846	FlyBaseID:	FBgn0028582	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_732736.2	Gene:	lqfR / 42632	FlyBaseID:	FBgn0261279	Length:	1415	Species:	Drosophila melanogaster

Alignment Length:	774	Identity:	189/774 - (24%)
Similarity:	293/774 - (37%)	Gaps:	229/774 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VAGLRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKR-LND 75
            |..|...:.|:..||::.:.||||||::|||||:..:|.|:|..|::...|.|:|.|:||| |.|
  Fly    11 VRELADKVTNVVMNYTETEGKVREATNDDPWGPTGPLMQELAYSTFSYETFPEVMSMLWKRMLQD 75

  Fly    76 HGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEE-GKDQGTHVREKAKQLV 139
            :..|||..||:|:||.||::.|||:|....:|:|:.:::|..:.:.:| |||||.:||.|.::|:
  Fly    76 NKTNWRRTYKSLLLLNYLVRNGSERVVTSSREHIYDLRSLENYTFTDEGGKDQGINVRHKVRELI 140

  Fly   140 TLLKDDERLKNERVKAQKAKERF--------------------AQNPSGFGSDGYIDGPSQRDLP 184
            ..::||:||:.||.||:|.|:::                    .....|.||.||.||..:....
  Fly   141 DFIQDDDRLREERKKAKKNKDKYIGMSSDAMGMRSGGYSGYSGGSGGGGGGSGGYNDGDYRSSRG 205

  Fly   185 PGWQEEPPKSVSELEMVRPQTAGEEELQLQLAMAMSREEAEQEEAKRRSDDVRLQLALSQSEQDF 249
            ..|..:  ||.                               ::.:...||.........|:.|.
  Fly   206 DNWYSD--KSA-------------------------------DKDRYEDDDTHYDGEREGSDSDS 237

  Fly   250 KDP------NGRPIPAPKKEEQQSHLLDLLDISLGATSISSP----PLGAAGGAPTAVVDPWAMP 304
            ..|      |.|..||....|.:.   ..|::::.:.::|||    |...|...|
  Fly   238 PSPRRNYRYNDRASPAEVASEAKP---SSLNMNIRSKTVSSPVSKQPTSTASAKP---------- 289

  Fly   305 GPRAPSQLSDPWSGTSSPQVDPWNPSAAPRTILGA----GVPMTSAPLGAGN------------- 352
                         ..|..::|           |||    |.|   ||.||..
  Fly   290 -------------ALSQKKID-----------LGAAANFGKP---APGGAAGIHSPTHRDTPTSV 327

  Fly   353 DAWGARTQSPSVASGSSNEGWLQSNGNANQNGRGATPAGPPAEGWLIKSTAVGALGAAPINHAAN 417
            |..|..:.|||.:..::|   .|||.|...:....|.:.||.:...:.|.||........|..|:
  Fly   328 DLMGGASPSPSTSKANNN---TQSNNNDLLDDLFKTCSPPPGQEKTLNSAAVIVDDDDDFNPRAS 389

  Fly   418 N-------------GSSSSDPWLAEPAASAAGGAAAVGLADPWAPGAASQTGAGALDDPWKALGT 469
            :             |..|:...::||.::....||....|| :|....|.|...|||.
  Fly   390 DASQQEFGDFASAFGQPSAGSTISEPPSTGLVPAANDEFAD-FAAFQGSTTSTSALDG------- 446

  Fly   470 GAIKKQSPEFDEFDLITNRNKSEHSNSNASN----NNNASLLDDMDPLSANYGNGGINSSMH--- 527
            ..:|..:|..|.|||..:...|..:.:.|::    ..:.|:...| |::........|.||.
  Fly   447 NLLKTATPANDSFDLFNSAPTSTAAATTATDLLAGLGDLSIHQSM-PMAVEEQLASSNDSMSSAS 510

  Fly   528 ---PSTG-----ATAKKSIKD------------AHSFLGE--NS----------ALVNLDNLIKP 560
               ||..     :.|:|.::|            ..:.|||  ||          .||.||.
  Fly   511 PQPPSEAMRLAFSKAQKQLRDLMQVQSASAVAQVAAILGELHNSNALPGFTTPEQLVGLDR---- 571

  Fly   561 IAPQTQTGNQPAYNPFSDNVVPPKTNLFQQQQPA----VPSINQLKQQAPFSVSMNQDPWAPVMG 621
               ||......|:..:: .::...|.||.|..|.    |..:|..|....|..
  Fly   572 ---QTCDWTCLAHGEYA-ALLNQLTELFSQDWPEPSQDVEVVNIFKLDHSFDY------------ 620

  Fly   622 GVSTTSQPKLPPPVRPTSLNLGPSSVGEFQLLSALSNPI-------IPIAHIPQPQPNL 673
             ||...:.      ..|.|:..||::.     |.|.|.:       |.:.||.:.:.:|
  Fly   621 -VSVAFES------LQTRLDKFPSTIS-----SLLENMVKDESLISIALLHISRQRASL 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqf	NP_729266.2	ENTH_epsin	28..149	CDD:239627	54/122 (44%)
lqf	NP_729266.2	UIM	208..227	CDD:197845	0/18 (0%)
lqfR	NP_732736.2	ENTH_epsin	27..150	CDD:239627	54/122 (44%)
		DUF4045	<226..459	CDD:289995	61/283 (22%)
		Telomere_reg-2	1072..1184	CDD:287202
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D34185at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12276
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2102
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.980