Protein Alignment lqf and EPN1

DIOPT Version :10

• Sequence 1: NP_729266.2
• Gene: lqf / 38846
• FlyBaseID: FBgn0028582
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_001123543.1
• Gene: EPN1 / 29924
• HGNCID: 21604
• Length: 662
• Species: Homo sapiens
• Alignment Length: 670
• Identity: 263/670 - (39%)
• Similarity: 344/670 - (51%)
• Gaps: 157/670 - (23%)

  Fly    10 VNVAGLRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLN 74
            ::.:.|||.:||:.||||:|::||||||||||||||:::|||||:||||||||||||.|||||||
Human   112 MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLN 176

  Fly    75 DHGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFE-EGKDQGTHVREKAKQL 138
            ||||||||||||:.|:|||||||||:|:||||||::|:|||::|.|.: :|||||.:||||||||
Human   177 DHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQL 241

  Fly   139 VTLLKDDERLKNERVKAQKAKERFAQNPSGFGSDGYIDGPSQRDLPPGWQEEPPKSVSELEMVRP 203
            |.||:|::||:.||..|.|.||:.||..:. .|.....||            ||    |.|...|
Human   242 VALLRDEDRLREERAHALKTKEKLAQTATA-SSAAVGSGP------------PP----EAEQAWP 289

  Fly   204 QTAGEEELQLQLAMAMSREEAEQEEAKRRSDDVRLQLALSQSEQDFKDPNGRPIPAPKKEEQQSH 268
            |::||||||||||:|||:|||:|||..||.||:|||:|:.:|:   ::..|:         ::|.
Human   290 QSSGEEELQLQLALAMSKEEADQEERIRRGDDLRLQMAIEESK---RETGGK---------EESS 342

  Fly   269 LLDLLDISLGATSISSPPLGAAGGAPTAVVDPWAMPGPRA-----PSQLSDPWSGTS-SPQVDPW 327
            |:||.|:      .::|       ||....|||..|.|.|     .:..||||.|.. .|..|||
Human   343 LMDLADV------FTAP-------APAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPW 394

  Fly   328 NPSAAPRTILGAGVPMTSAPLGAGNDAWGARTQSPSVASGSSNEGWLQSNGNANQNGRGATPA-- 390
                        |.|   ||..|..|.|     .|:..:|.|.:.|            |.|||
Human   395 ------------GGP---APTPASGDPW-----RPAAPAGPSVDPW------------GGTPAPA 427

  Fly   391 ---GPPAEGWLIKSTAVGAL-GAAPINHAANNGSSSSDPWLAEPAASAAGGAAAVGLADPW--AP 449
               ||..:.|       |:. |..|:     :|.|:||||...||.|           |||  :|
Human   428 AGEGPTPDPW-------GSSDGGVPV-----SGPSASDPWTPAPAFS-----------DPWGGSP 469

  Fly   450 GAASQTGAGALDDPWKALGTGAIKKQSPEFDEFDLITNRNKSEHSNSNASNNNNASLLDDMDPLS 514
            ...|..|..|         .|....:..||.:||    |.::....|.:|......|..::...|
Human   470 AKPSTNGTTA---------AGGFDTEPDEFSDFD----RLRTALPTSGSSAGELELLAGEVPARS 521

  Fly   515 AN-YGNGGINSSMHPSTGATAKKSI--------KDAHSFLGENSALVNLDNLIKPIAPQTQTGNQ 570
            .. :...|:..|:..:.|:....:.        |...||||.|:|||:||:|:....| |..|.:
Human   522 PGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGP-TPPGAK 585

  Fly   571 PAYNPF----SDNVVPPKTNLFQQQQPAVPSINQLKQQAPFSVSMNQDPWAPVMGGVST-----T 626
             |.|||    .....|..||.||...||..::|||:          ..|..||.|...|     .
Human   586 -ASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLR----------LSPVPPVPGAPPTYISPLG 639

  Fly   627 SQPKLPP--PVRPTSLNLGP 644
            ..|.|||  |..|.:.|..|
Human   640 GGPGLPPMMPPGPPAPNTNP 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lqf	NP_729266.2	ENTH_Epsin	28..150	CDD:340787	93/122 (76%)
		UIM	208..227	CDD:197845	15/18 (83%)
		PHA03247	<278..394	CDD:223021	35/126 (28%)
EPN1	NP_001123543.1	ENTH_Epsin	130..253	CDD:340787	93/122 (76%)
		PRK07764	<351..524	CDD:236090	65/247 (26%)