Protein Alignment lqf and EPN2

DIOPT Version :10

• Sequence 1: NP_729266.2
• Gene: lqf / 38846
• FlyBaseID: FBgn0028582
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_055779.2
• Gene: EPN2 / 22905
• HGNCID: 18639
• Length: 641
• Species: Homo sapiens
• Alignment Length: 793
• Identity: 286/793 - (36%)
• Similarity: 374/793 - (47%)
• Gaps: 254/793 - (32%)

  Fly    10 VNVAGLRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLN 74
            :..:.:||.:||:.:|||:|::||||||||||||||:::|:|||:||||||||||||.|:|||||
Human     1 MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLN 65

  Fly    75 DHGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFE-EGKDQGTHVREKAKQL 138
            |||||||||||||.||:||||||||:|||||:|||||||||::|.|.: :|||||.:||||:|||
Human    66 DHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQL 130

  Fly   139 VTLLKDDERLKNERVKAQKAKERFAQNPSGFGSD--GYIDGPSQRDL------------------ 183
            |.||||:||||.||.:|.|.|||.||..:|.||:  .:..|.||.:|
Human   131 VALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTSHSEQEYGKAGGSPAS 195

  Fly   184 -----------------PPGWQEE--------------------------------------PPK 193
                             |.|..||                                      .|:
Human   196 YHGSPEASLCPQHRTGAPLGQSEELQPLSQRHPFLPHLGLASRPNGDWSQPCLTCDRAARATSPR 260

  Fly   194 SVSELEMVRPQTAGEEELQLQLAMAMSREEAEQEEAKRRSDDVRLQLALSQSEQDFKDPNGRPIP 258
            ..||||..||||:||||||||||:|||||.|||||..||.||:|||:||.:|.:|       .:.
Human   261 VSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLRRGDDLRLQMALEESRRD-------TVK 318

  Fly   259 APKKEE-----QQSHLLDLLDI--SLGATSISSPPLGAAGGAPTAVVDPWAMPGPRAPSQLSDPW 316
            .|||:|     ||:.||||:|.  |.|..:..:.|.|.:  |.|...:||.  ||.||:..||||
Human   319 IPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPS--ASTNQTNPWG--GPAAPASTSDPW 379

  Fly   317 S--GTS-SPQVDPWNPSAAPRTILGAGVPMTSAPLGAGNDAWGARTQSPSVASGSSNEGWLQSNG 378
            .  ||. :..:|||            |||.            ||..||
Human   380 PSFGTKPAASIDPW------------GVPT------------GATVQS----------------- 403

  Fly   379 NANQNGRGATPAGPPAEGWLIKSTAVGALGAAPINHAANNGSSSSDPWLA--EPAASAAGGAAAV 441
                                           .|.|         ||||.|  :||:||...|
Human   404 -------------------------------VPKN---------SDPWAASQQPASSAGKRA--- 425

  Fly   442 GLADPWAPGAASQTGAGALDDPWKALG--TGAIKKQSPEFDEFDLITNRNKSEHSNSNASNNNNA 504
              :|.|  ||.|.|...::...::...  .|.||....|||  :|.|::..:|...|..|.||..
Human   426 --SDAW--GAVSTTKPVSVSGSFELFSNLNGTIKDDFSEFD--NLRTSKKTAESVTSLPSQNNGT 484

  Fly   505 SLLDDMDPLSANYGNGGINSSMHPSTGATAKKSI--KDAHSFLGENSALVNLDNLIKPIAPQTQT 567
            :   ..||..:           .|.|.|::|.|.  |...||||.|:||||||:|:...||..|
Human   485 T---SPDPFES-----------QPLTVASSKPSSARKTPESFLGPNAALVNLDSLVTRPAPPAQ- 534

  Fly   568 GNQPAYNPFSDNVVPPKT---NLFQQQQPAVPSINQLKQQAPFSVSMNQDPWAPVMGGVSTTSQP 629
                :.|||.....|..:   |.||..||...::|||:             .:||:|
Human   535 ----SLNPFLAPGAPATSAPVNPFQVNQPQPLTLNQLR-------------GSPVLG-------- 574

  Fly   630 KLPPPVRPTSLNLGPSSVGEFQLLSALSNPIIPIAHIPQPQPNLQVYNNAYQ--SSSSTNILGKS 692
                    ||.:.||....|...::::::        ..|||.|....::..  ..:..|::|..
Human   575 --------TSTSFGPGPGVESMAVASMTS--------AAPQPALGATGSSLTPLGPAMMNMVGSV 623

  Fly   693 NIPTNMNSSTSNS 705
            .||.:...:|..:
Human   624 GIPPSAAQATGTT 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lqf	NP_729266.2	ENTH_Epsin	28..150	CDD:340787	96/122 (79%)
		UIM	208..227	CDD:197845	16/18 (89%)
		PHA03247	<278..394	CDD:223021	27/118 (23%)
EPN2	NP_055779.2	ENTH_Epsin	19..141	CDD:340787	95/121 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..214		5/50 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..275		9/19 (47%)
		Herpes_BLLF1	<320..550	CDD:282904	97/342 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..425		39/169 (23%)
		6 X 3 AA repeats of [DE]-P-W	352..639		109/435 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	470..512		13/55 (24%)
		3 X 3 AA repeats of N-P-F	537..639		29/137 (21%)