DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lqf and Clint1

DIOPT Version :9

Sequence 1:	NP_729266.2	Gene:	lqf / 38846	FlyBaseID:	FBgn0028582	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001333689.1	Gene:	Clint1 / 216705	MGIID:	2144243	Length:	641	Species:	Mus musculus

Alignment Length:	773	Identity:	200/773 - (25%)
Similarity:	319/773 - (41%)	Gaps:	204/773 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKR-LNDHGKNWRHVY 84
            |:..|||:.:.||||||::||||||..:|.|||:.|:....|.|:|.|:|.| |.|:.||||.||
Mouse    16 NVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKNWRRVY 80

  Fly    85 KALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEE-GKDQGTHVREKAKQLVTLLKDDERL 148
            |:|:||.|||:.|||:|....:|:|:.:::|..:.:.:| |||||.::|:|.|:||...:||:||
Mouse    81 KSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKELVEFAQDDDRL 145

  Fly   149 KNERVKAQKAKERF----AQNPSGFG-SDGYIDGPSQRDLPPGWQEEPPKSVSELEMVRPQTAGE 208
            :.||.||:|.|:::    :.:..||. ::.|...|..:     |.||..|:.|..    |.:...
Mouse   146 REERKKAKKNKDKYVGVSSDSVGGFRYNERYDPEPKSK-----WDEEWDKNKSAF----PFSDKL 201

  Fly   209 EELQLQLAMAMS------REEAEQEEAKRRSDDVRLQLALSQSEQDFKDPNGRPIPAPKKEEQQS 267
            .||..::...:.      |.:..::..:|.||          |:::.|...||......|:|:::
Mouse   202 GELSDKIGSTIDDTISKFRRKDREDSPERCSD----------SDEEKKARRGRSPKGEFKDEEET 256

  Fly   268 ------HLLDLLD---------------ISLGATS-----ISSPPLGAAGGAPTAVVDPWAMPGP 306
                  |:....:               |.|||.:     .:||...|:...|.:...| ::|..
Mouse   257 VTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASPDQNASTHTPQSSAKP-SVPSS 320

  Fly   307 RAPSQLSDPWSGTSSPQVDPWNPSAAPRTILGAGVPMTSAPLGAGNDAWGARTQS---PSVA-SG 367
            ::...|.|.:.|:|.                .||   .||.|..|...:|:...|   ||.| ||
Mouse   321 KSSGDLVDLFDGSSQ----------------SAG---GSADLFGGFADFGSAAASGNFPSQATSG 366

  Fly   368 SSNEG-WLQSNGNANQNGRGATPAGPPAEGWLIKSTAVGAL-GAAPINHAANNGSSSSDPWLAEP 430
            :.:.| |...|         ..|:||.|.|        |.| |:||  .:|....|:|.|.|..|
Mouse   367 NGDFGDWSAFN---------QAPSGPVASG--------GELFGSAP--QSAVELISASQPALGPP 412

  Fly   431 AASAAGGAAAVGLADPWAPGAASQTGAGALDDPWKALGTGAIKKQSPEFDEFDLITNRNKSEHSN 495
            .|:    :.:..|.|......|:.|.:.:::  :..:.|..:....|               .|.
Mouse   413 PAA----SNSADLFDLMGSSQATMTSSQSMN--FSLMSTNTVGLGLP---------------MSR 456

  Fly   496 SNASNNNNASLLDDMDPLSANYGNGGINSSMHPSTGATAKKSIKDAHSFLGENSALVNLDNLIKP 560
            |....|.:| :|...:||            .|.:|....|.:.|...|...:.|..::||||:
Mouse   457 SQPLQNVSA-VLQKPNPL------------YHQNTDMVQKSASKTLPSTWSDPSVNISLDNLL-- 506

  Fly   561 IAPQTQTGNQPAYNPFSDNVVPPKTNLFQQQQPAVPS-INQLKQQAPFSVSMNQDPWAPVMGGVS 624
                  .|.||:                :.|||::.: |.|...|.|.:| |.|.     .|.|:
Mouse   507 ------PGMQPS----------------KPQQPSLNTMIQQQNMQQPLNV-MTQS-----FGAVN 543

  Fly   625 TTSQPKLPPPVRPTSLNLGPSSVGEFQLLSALSNPIIPIAHIPQPQPNLQVYNNAYQSSSSTNIL 689
            .:| |....||||.                  :||::. ..:|...|.:...........::..:
Mouse   544 LSS-PSNMLPVRPQ------------------TNPLLG-GPMPMNMPGVMTGTMGMAPLGNSAGM 588

  Fly   690 GKSNIPTNMNSSTSNSTIHSCYASPSPGVDGIRNMDIFTERPYYNSPTA---PADDTY 744
            .:..:..|||...|.|.:         |:.|...|.:    |....|:.   |..|.:
Mouse   589 SQGMVGMNMNMGMSASGM---------GLSGTMGMGM----PSMAMPSGTVQPKQDAF 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqf	NP_729266.2	ENTH_epsin	28..149	CDD:239627	59/122 (48%)
lqf	NP_729266.2	UIM	208..227	CDD:197845	3/24 (13%)
Clint1	NP_001333689.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263849at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2102
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950