DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lqf and ENTHD1

DIOPT Version :9

Sequence 1:	NP_729266.2	Gene:	lqf / 38846	FlyBaseID:	FBgn0028582	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_689725.2	Gene:	ENTHD1 / 150350	HGNCID:	26352	Length:	607	Species:	Homo sapiens

Alignment Length:	746	Identity:	196/746 - (26%)
Similarity:	301/746 - (40%)	Gaps:	204/746 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLNDHGKNW 80
            ||.:||...|||||::||||||||||||||:::|.:|::||:|.::.||||.|:|.|||||||||
Human     4 RRQVKNFVKNYSDAEIKVREATSNDPWGPSSSLMLDISDLTFNTISLSEIMNMLWHRLNDHGKNW 68

  Fly    81 RHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEE-GKDQGTHVREKAKQLVTLLKD 144
            |||||:|.|::||||.||:||.|.|:|....:|||::|.:.:| |||||.::|||:||::|||.|
Human    69 RHVYKSLTLMDYLIKNGSKKVIQHCREGFCNLQTLKDFQHIDEAGKDQGYYIREKSKQVITLLMD 133

  Fly   145 DERLKNERVKAQKAKER------FAQNPSGFGSD--GYIDGPSQRDLPPGWQEEPPKSVSELEMV 201
            :..|..||..|.:.::|      |::...|..:.  .....|:           |..|.||.:..
Human   134 EPLLCKEREVACRTRQRTSHSILFSKRQLGSSNSLTACTSAPT-----------PDISASEKKYK 187

  Fly   202 RPQTAGEEELQLQLAMAMSREEAEQEEAKRRSDDVRL--QLALSQSEQDFKDPNGRPIPAPKKEE 264
            .|:..     :|.....:.:...:||..:    ||.|  :..|||.....|      |...|..|
Human   188 LPKFG-----RLHNKRNVCKAGLKQEHCQ----DVHLPTETMLSQETLPLK------IHGWKSTE 237

  Fly   265 QQSHLLDLLDISLGATSISSPPLGAAGGAPTAVVDPWA----------MPGPRAPSQLSD--PWS 317
            .   |:..||.......:::||         ::|.|..          :.|..|...||:  | |
Human   238 D---LMTFLDDDPELPLLATPP---------SIVSPITCLSEAEEVCNLSGADAVPTLSENSP-S 289

  Fly   318 GTSSPQVDPWNPSAAPRTILGAGVPMTSAPLGAGNDAWGARTQSPSVASGSSNEGWLQSNGNANQ 382
            |.....:|..:......|:.   ..:...||...:.|.|.:|.:...|..||.|.::..:...::
Human   290 GQRDVSLDKRSDGIFTNTVT---ENLLETPLEKQSAAEGLKTLTILPACWSSKEEFISPDLRVSK 351

  Fly   383 NGRGATPAGPPAEGWLIKSTAVGALGAAP------------INHAANNGSSSS----DPWL--AE 429
                       ::.......:|..|..:|            ||.|....:.||    |..|  ..
Human   352 -----------SDSTFHNQASVETLCLSPSFKIFDRVKEIVINKAYQKPAQSSIQMDDKILKTTT 405

  Fly   430 PAASAAGGAAAVGLADPWAPGAASQTGAGALDDP-------WKALGTGAIKKQSPEFDEFDLITN 487
            ..::|:.||::.......:|..||...:..|..|       |      .:..|......|.....
Human   406 RVSTASEGASSFSPLSMSSPDLASPEKSAHLLSPILAGPSFW------TLSHQQLSSTSFKDEDK 464

  Fly   488 RNKSEHS-------NSNASNNNNASLLDDMDPLSANYGNGGINSSMHPSTGATAKKSIKD-AHSF 544
            ..|..||       :|:...|::.:||                 .:.|:...:|||:|.. :.|.
Human   465 TAKLHHSFASRGPVSSDVEENDSLNLL-----------------GILPNNSDSAKKNISHISSSH 512

  Fly   545 LGENSALVNLDNLIKPIAPQTQTGNQPAYNPFSDNVVPPKTNLFQQQQPAVPSINQLKQQAPFSV 609
            .||.|. .|:|..|    |.:.:|.|             .|..|.|:..|..||:.|.::...::
Human   513 WGEFST-QNVDQFI----PLSCSGFQ-------------STKDFPQEPEAKNSISVLLREVKRAI 559

  Fly   610 S-MNQDPWAPVMGGVSTTSQPKLPPPVRPTSLNLGPSSVGEFQLLSALSNPIIPIAHIPQPQPNL 673
            : :::|        :||..|                                           .|
Human   560 ARLHED--------LSTVIQ-------------------------------------------EL 573

  Fly   674 QVYNNAYQSSS--STNILGKSNIPTNMNSST 702
            .|.||...|.|  |:.|...|.:|.:...|:
Human   574 NVINNILMSMSLNSSQISQSSQVPQSSEGSS 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqf	NP_729266.2	ENTH_epsin	28..149	CDD:239627	73/121 (60%)
lqf	NP_729266.2	UIM	208..227	CDD:197845	1/18 (6%)
ENTHD1	NP_689725.2	ENTH	14..137	CDD:307533	75/122 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143861
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2056
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263849at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940