DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ltl and MFHAS1

DIOPT Version :9

Sequence 1:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_004216.2	Gene:	MFHAS1 / 9258	HGNCID:	16982	Length:	1052	Species:	Homo sapiens

Alignment Length:	374	Identity:	101/374 - (27%)
Similarity:	167/374 - (44%)	Gaps:	41/374 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 LSNVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRL 172
            |.::..|::|:|.|:|:|:...|.:.||..|.:.|.:...:..........:|.|.:..|.:|.|
Human    62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTAL 126

  Fly   173 --DRGSFPKSLLILHLGRNQLESLNGSLHDLHNLESLFINANNITSLDDELPDGGQLRLLMAHNN 235
              :..|..:.|..|:|..|||.:|...|..|.:||.|.::.|.:..|.|.|....:||.|...:|
Human   127 GAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHN 191

  Fly   236 RLERLPANMAGMHSLETVHIHCNQLRSFDRVLRNAVNLSEVMADNNELEYLAQDEFASCSKVETL 300
            :|...|..:..:.:||.:.:..|:||.....:.....|..:.....||..|... |...:.:|:|
Human   192 QLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAG-FCELASLESL 255

  Fly   301 QMGCNHIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQ 365
            .:..|.:::|.:....:.:||..|.|.|..|||..|                    ||| ..|::
Human   256 MLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA--------------------LLP-LAGLE 299

  Fly   366 ELMLVNLDLDNNRIDSLNGALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILD---LTGNQLA 427
            ||.     |..|::.|:...::|||.|..|.|..||:.:|.    |.::.|..|:   |.|||:|
Human   300 ELY-----LSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLP----DSIVELTGLEELVLQGNQIA 355

  Fly   428 ELKPLEMTLLPSLKILKVAYNNITK--LEQDFKGLPVLC--QANLTNNQ 472
            .| |.....|..:.:.|:..|.:.:  .|...||:|.:.  |..|.::|
Human   356 VL-PDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQ 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380
		LRR_8	86..145	CDD:290566	12/36 (33%)
		leucine-rich repeat	87..110	CDD:275380	1/1 (100%)
		leucine-rich repeat	111..134	CDD:275380	7/22 (32%)
		leucine-rich repeat	135..158	CDD:275380	3/22 (14%)
		LRR_8	158..214	CDD:290566	19/57 (33%)
		leucine-rich repeat	159..180	CDD:275380	6/22 (27%)
		leucine-rich repeat	181..203	CDD:275380	9/21 (43%)
		leucine-rich repeat	204..226	CDD:275380	7/21 (33%)
		LRR_RI	226..451	CDD:238064	60/227 (26%)
		leucine-rich repeat	227..249	CDD:275380	6/21 (29%)
		leucine-rich repeat	250..272	CDD:275380	5/21 (24%)
		leucine-rich repeat	273..296	CDD:275380	5/22 (23%)
		leucine-rich repeat	297..315	CDD:275380	4/17 (24%)
		LRR_8	319..402	CDD:290566	25/82 (30%)
		leucine-rich repeat	320..335	CDD:275378	8/14 (57%)
		leucine-rich repeat	344..366	CDD:275380	4/21 (19%)
		leucine-rich repeat	367..391	CDD:275380	6/23 (26%)
		LRR_8	369..426	CDD:290566	18/59 (31%)
		leucine-rich repeat	392..415	CDD:275380	7/22 (32%)
		leucine-rich repeat	416..439	CDD:275380	10/25 (40%)
		LRR_8	438..>479	CDD:290566	9/39 (23%)
		leucine-rich repeat	440..462	CDD:275380	5/23 (22%)
		leucine-rich repeat	463..483	CDD:275380	3/12 (25%)
MFHAS1	NP_004216.2	Required for interaction with PPP2R2A. /evidence=ECO:0000269\|PubMed:28609714	64..649		100/372 (27%)
		Required for interaction with PJA2. /evidence=ECO:0000269\|PubMed:28471450	64..364		90/331 (27%)
		leucine-rich repeat	68..88	CDD:275380	7/19 (37%)
		LRR_8	88..147	CDD:290566	14/58 (24%)
		leucine-rich repeat	89..112	CDD:275380	3/22 (14%)
		leucine-rich repeat	113..136	CDD:275380	6/22 (27%)
		LRR_RI	124..354	CDD:238064	72/260 (28%)
		leucine-rich repeat	137..182	CDD:275380	16/44 (36%)
		LRR_8	159..216	CDD:290566	16/56 (29%)
		leucine-rich repeat	160..173	CDD:275380	4/12 (33%)
		leucine-rich repeat	183..205	CDD:275380	6/21 (29%)
		leucine-rich repeat	206..228	CDD:275380	5/21 (24%)
		leucine-rich repeat	229..251	CDD:275380	5/22 (23%)
		LRR_8	251..308	CDD:290566	21/82 (26%)
		leucine-rich repeat	252..274	CDD:275380	4/21 (19%)
		leucine-rich repeat	275..297	CDD:275380	12/42 (29%)
		LRR_8	297..354	CDD:290566	21/65 (32%)
		leucine-rich repeat	298..320	CDD:275380	7/26 (27%)
		leucine-rich repeat	321..343	CDD:275380	8/25 (32%)
		leucine-rich repeat	344..364	CDD:275380	8/20 (40%)
		P-loop_NTPase	409..>552	CDD:304359
		COR	660..906	CDD:292713
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910