DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ltl and Tril

DIOPT Version :10

Sequence 1:NP_729265.1 Gene:ltl / 38845 FlyBaseID:FBgn0268063 Length:817 Species:Drosophila melanogaster
Sequence 2:NP_080093.1 Gene:Tril / 66873 MGIID:1914123 Length:809 Species:Mus musculus


Alignment Length:674 Identity:154/674 - (22%)
Similarity:241/674 - (35%) Gaps:195/674 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 YLSIGDNDLDEIPKHALSHMPS---LLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDR 174
            :|...:..|..:||  .|.:||   :||..:|...|..:...||..:.::..|.|..|.|..|..
Mouse    38 HLLCTNRGLRAVPK--TSSLPSPQDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHP 100

  Fly   175 GSFPK--SLLILHLGRNQLESL-NGSLHDLHNLESLFINANNITSLDDELPDGGQLRLLMAHNNR 236
            .:|.|  .|..|:||.|.|::| .|:|..|..|..|:.|.|.|                    .|
Mouse   101 KTFEKLSRLEELYLGNNLLQALVPGTLAPLRKLRILYANGNEI--------------------GR 145

  Fly   237 LERLPANMAGMHSLETVHIHCNQLRSF-DRVLRNAVNLSEVMADNNELEYLAQDEFASCSKVETL 300
            |.|  .:..|:.||..:.:..|.|.:. |.|.....||..:..::|.:.:|.::.|:...|:..|
Mouse   146 LSR--GSFEGLESLVKLRLDGNVLGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFSQLGKLRFL 208

  Fly   301 QMGCNHIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQ 365
            .:..|.::.         .|::|            |....||||.||.||:|.:|.|  .||..|
Mouse   209 NLSANELQP---------SLRHA------------ATFVPLRSLSTLILSANSLQHL--GPRVFQ 250

  Fly   366 EL-MLVNLDLDNNRIDSL-NGALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAE 428
            .| .|..|.|..|::..| ..|..||..||.|.|.||||..|.:...:.:..|:.|||:||:|:.
Mouse   251 HLPRLGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSA 315

  Fly   429 LKPLEMTLLPSLKILKVAYNNITKLEQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPG 493
            |.|             ..:.:..:|.          :.:|.:|.:|.:|.::...:       |.
Mouse   316 LHP-------------ATFGHQGRLR----------ELSLRDNALSALSGDIFAAS-------PA 350

  Fly   494 KLEIHLDDNPIMCDVGLNELCRLMAVQEAR---------------IRGRSQCFENDQEVCTVLPM 543
            ...:.||.|...||..|..|.|.|....::               :||:...:.:||       :
Mouse   351 LYRLDLDGNGWTCDCRLRGLKRWMGNWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQ-------L 408

  Fly   544 LYNVNLPIMVTNLKLTGREVPKPMVRVIVPSLIKANNELLPPLIATLGNPVLISTDLVNPVISPL 608
            |.|.:......:.....|:.|.|          .::.|.:.|       |..:|.:|   .:.|.
Mouse   409 LQNGSCVDPSPSPTAGSRQWPLP----------TSSEEGMTP-------PAGLSQEL---PLQPQ 453

  Fly   609 PPP-------------------------LLLATTTPPP------------PLPLPVESEVEKNES 636
            |.|                         |.|:...|.|            |..|.:..:..:...
Mouse   454 PQPQQRGRLLPGVAWGGAAKELVGNRSALRLSRRGPGPHQGPSAAAPGSAPQSLDLHEKPGRGRH 518

  Fly   637 TTANPVPTNYTQETTTTTSTTTTTTTTETSSQVAPIEIITTTAPTTTTTSTTTPKPNETLPVIVE 701
            |.||...|    |.|.|:...:.|.:...|.|.|..:.:.:....:...|               
Mouse   519 TRANLSQT----EPTPTSEPASGTPSARDSWQRAAKQRLASEQQESAVQS--------------- 564

  Fly   702 LQDPNPPDTTVNQTALVPPVVLDP 725
                      |:...| ||:|.||
Mouse   565 ----------VSGVGL-PPLVSDP 577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ltlNP_729265.1 LRR 65..476 CDD:443914 101/371 (27%)
leucine-rich repeat 65..86 CDD:275380
leucine-rich repeat 87..110 CDD:275380
leucine-rich repeat 111..134 CDD:275380 5/20 (25%)
leucine-rich repeat 135..158 CDD:275380 6/22 (27%)
leucine-rich repeat 159..180 CDD:275380 7/22 (32%)
leucine-rich repeat 181..203 CDD:275380 10/22 (45%)
leucine-rich repeat 204..226 CDD:275380 5/21 (24%)
leucine-rich repeat 227..249 CDD:275380 4/21 (19%)
leucine-rich repeat 250..272 CDD:275380 5/22 (23%)
leucine-rich repeat 273..296 CDD:275380 4/22 (18%)
leucine-rich repeat 297..315 CDD:275380 2/17 (12%)
leucine-rich repeat 320..335 CDD:275378 2/14 (14%)
leucine-rich repeat 344..366 CDD:275380 10/21 (48%)
leucine-rich repeat 367..391 CDD:275380 9/25 (36%)
leucine-rich repeat 392..415 CDD:275380 9/22 (41%)
leucine-rich repeat 416..439 CDD:275380 9/22 (41%)
leucine-rich repeat 440..462 CDD:275380 1/21 (5%)
leucine-rich repeat 463..483 CDD:275380 4/19 (21%)
TrilNP_080093.1 LRRNT 27..56 CDD:214470 5/19 (26%)
leucine-rich repeat 37..57 CDD:275378 5/20 (25%)
LRR 1 61..81 6/19 (32%)
LRR_8 65..119 CDD:404697 16/53 (30%)
LRR 2 84..105 6/20 (30%)
leucine-rich repeat 85..108 CDD:275380 7/22 (32%)
LRR 104..>359 CDD:443914 86/329 (26%)
LRR 3 108..129 9/20 (45%)
leucine-rich repeat 109..132 CDD:275380 10/22 (45%)
LRR 4 132..153 8/42 (19%)
leucine-rich repeat 133..156 CDD:275380 9/44 (20%)
LRR 5 156..177 6/20 (30%)
leucine-rich repeat 157..180 CDD:275380 5/22 (23%)
LRR 6 180..201 5/20 (25%)
leucine-rich repeat 181..204 CDD:275380 4/22 (18%)
LRR 7 204..223 5/39 (13%)
leucine-rich repeat 205..230 CDD:275380 6/45 (13%)
LRR 8 230..251 11/22 (50%)
leucine-rich repeat 231..254 CDD:275380 12/24 (50%)
LRR 9 254..275 6/20 (30%)
leucine-rich repeat 255..278 CDD:275380 8/22 (36%)
LRR 10 278..298 9/19 (47%)
leucine-rich repeat 279..302 CDD:275380 9/22 (41%)
LRR 11 302..323 9/33 (27%)
leucine-rich repeat 303..323 CDD:275380 9/32 (28%)
LRR 12 326..347 5/30 (17%)
leucine-rich repeat 327..350 CDD:275380 5/39 (13%)
PCC 332..>441 CDD:188093 25/139 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 412..462 11/69 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 483..563 16/83 (19%)
FN3 587..665 CDD:473895
Blue background indicates that the domain is not in the aligned region.

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