DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ltl and igfals

DIOPT Version :9

Sequence 1:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	XP_003198203.1	Gene:	igfals / 570758	ZFINID:	ZDB-GENE-061009-25	Length:	614	Species:	Danio rerio

Alignment Length:	607	Identity:	152/607 - (25%)
Similarity:	247/607 - (40%)	Gaps:	141/607 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LNADTNIDLKITHSQLDDLEMRSFT----DMNFNLYKLRMQWNSLKSLPEVPFRGLSNVTYLSIG 117
            |..|.:::|.:..|      .|:||    |:..:...|.:..|...:||...|..|:|:.:|::.
Zfish    56 LQDDYSLELNVYCS------TRNFTQVPSDIPLSTRSLWLDGNLFSNLPAGAFEKLTNLEFLNLQ 114

  Fly   118 DNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLL 182
            .:.|..:..||                        |||:                      .||.
Zfish   115 SSLLVSLDAHA------------------------FRGL----------------------NSLA 133

  Fly   183 ILHLGRNQLESLNGSL-HDLHNLESLFINANNITSLDDELPDG-GQLRLLMAHNNRLERLP-ANM 244
            .|||.||.|.||:|.: ....||.:|.:|.|.:..:||.|..| ..:.||....|.|..|| ...
Zfish   134 HLHLERNNLRSLSGLVFQGTSNLATLSLNNNQMFRIDDRLFAGMSHMWLLNLGWNLLSVLPETGF 198

  Fly   245 AGMHSLETVHIHCNQLRSFDRVLRNAVN-LSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIK 308
            ..:|.|..:.:..|:|......|...:| |.|:....|.|:.:..:.|....|::.|.:|.|.|.
Zfish   199 QDLHGLRELILAGNRLAYLQPQLFQGLNELKELDLTGNYLKVIKANVFLKLPKLQKLYLGQNQIV 263

  Fly   309 SLNSSLLPILKLKNANFSFNDIEEFSMAELH-----GLRSLKTLQLSSNRIQRLLP----DPRGV 364
            ::.......:|    :..:.|:....:..||     ||:||..|:||:|.|..|.|    |.:.:
Zfish   264 TVAPRAFVGMK----SLRWLDLSRNRLTVLHDETFIGLQSLHVLRLSNNSINSLRPGTFRDLQYL 324

  Fly   365 QELMLVNLDLDNNRIDSLN-GALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGN---- 424
            :||.|.     :|:|.:|. ....|||:|.:|||..|||:..::|.|.|:..|.::.|||:
Zfish   325 EELCLY-----HNQIRALGVRVFEGLGHLEVLNLENNRLQEARMGTFMGLNHLAVMKLTGSCFHS 384

  Fly   425 -------QLAELKPLEM-------------TLLPSLKILKVAYNNITKLE-QDFKGLPVLCQANL 468
                   .|::|..:.:             :.|..|:.|.:.:|||:.:| |.|..|..|.|.:|
Zfish   385 LPDQVFKGLSKLHSIHLDRSCLTKVSSQSFSGLTGLRRLFLQHNNISLVERQSFVELQRLQQLDL 449

  Fly   469 TNNQISTISSELVTNTRCKN-----------HNVPGKLEI---HLDDNPIMCDVGLNELCRLMAV 519
            ..|:::||:|.  |....||           ||:|.:..:   ||.    ..|:..|:| .|:..
Zfish   450 RFNKLTTITSN--TFYGLKNLDYLLLSGNLLHNLPAEALLPLQHLS----WLDLSGNKL-ELILN 507

  Fly   520 QEARIRGRSQCFENDQEVCTVLPMLYNVNLPIMVTNLKLTGRE-----VPKPMVRVIV--PSLIK 577
            ....:..|.:.......:...||    |::|..:..|.|:|..     ..||....|:  |.::.
Zfish   508 ATIYMLPRLRYLNLKDNILVNLP----VSIPESLDQLWLSGNNWKCDCSAKPFRDFILQKPQVVP 568

  Fly   578 ANNELL-----PPLIATLGNPV 594
            ...|:|     |..:.|:.|.|
Zfish   569 LQVEMLGEGEEPHTLITVYNNV 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	6/24 (25%)
		LRR_8	86..145	CDD:290566	11/58 (19%)
		leucine-rich repeat	87..110	CDD:275380	6/22 (27%)
		leucine-rich repeat	111..134	CDD:275380	4/22 (18%)
		leucine-rich repeat	135..158	CDD:275380	3/22 (14%)
		LRR_8	158..214	CDD:290566	16/56 (29%)
		leucine-rich repeat	159..180	CDD:275380	0/20 (0%)
		leucine-rich repeat	181..203	CDD:275380	10/22 (45%)
		leucine-rich repeat	204..226	CDD:275380	8/22 (36%)
		LRR_RI	226..451	CDD:238064	68/260 (26%)
		leucine-rich repeat	227..249	CDD:275380	6/22 (27%)
		leucine-rich repeat	250..272	CDD:275380	4/21 (19%)
		leucine-rich repeat	273..296	CDD:275380	5/22 (23%)
		leucine-rich repeat	297..315	CDD:275380	4/17 (24%)
		LRR_8	319..402	CDD:290566	30/92 (33%)
		leucine-rich repeat	320..335	CDD:275378	1/14 (7%)
		leucine-rich repeat	344..366	CDD:275380	9/25 (36%)
		leucine-rich repeat	367..391	CDD:275380	7/24 (29%)
		LRR_8	369..426	CDD:290566	21/68 (31%)
		leucine-rich repeat	392..415	CDD:275380	10/22 (45%)
		leucine-rich repeat	416..439	CDD:275380	7/46 (15%)
		LRR_8	438..>479	CDD:290566	15/41 (37%)
		leucine-rich repeat	440..462	CDD:275380	9/22 (41%)
		leucine-rich repeat	463..483	CDD:275380	7/19 (37%)
igfals	XP_003198203.1	LRRNT	48..81	CDD:279764	8/30 (27%)
		leucine-rich repeat	65..83	CDD:275380	5/23 (22%)
		leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		LRR_8	85..142	CDD:290566	21/102 (21%)
		leucine-rich repeat	108..131	CDD:275380	7/68 (10%)
		LRR_8	131..214	CDD:290566	29/82 (35%)
		leucine-rich repeat	132..155	CDD:275380	10/22 (45%)
		leucine-rich repeat	156..203	CDD:275380	14/46 (30%)
		leucine-rich repeat	204..227	CDD:275380	4/22 (18%)
		LRR_RI	<219..456	CDD:238064	67/245 (27%)
		LRR_8	227..286	CDD:290566	12/62 (19%)
		leucine-rich repeat	228..251	CDD:275380	5/22 (23%)
		leucine-rich repeat	252..275	CDD:275380	5/26 (19%)
		LRR_8	274..334	CDD:290566	20/68 (29%)
		leucine-rich repeat	276..299	CDD:275380	5/22 (23%)
		leucine-rich repeat	300..323	CDD:275380	9/22 (41%)
		leucine-rich repeat	324..347	CDD:275380	8/27 (30%)
		leucine-rich repeat	348..369	CDD:275380	9/20 (45%)
		LRR_8	371..430	CDD:290566	10/58 (17%)
		leucine-rich repeat	396..419	CDD:275380	2/22 (9%)
		LRR_8	418..478	CDD:290566	19/61 (31%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..467	CDD:275380	8/24 (33%)
		LRR_8	466..524	CDD:290566	12/62 (19%)
		leucine-rich repeat	468..486	CDD:275380	3/17 (18%)
		leucine-rich repeat	492..515	CDD:275380	5/27 (19%)
		leucine-rich repeat	516..540	CDD:275380	4/27 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100