Protein Alignment ltl and lrrtm4l2

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: XP_009302017.1
• Gene: lrrtm4l2 / 568695
• ZFINID: ZDB-GENE-080327-14
• Length: 557
• Species: Danio rerio
• Alignment Length: 746
• Identity: 145/746 - (19%)
• Similarity: 237/746 - (31%)
• Gaps: 324/746 - (43%)

  Fly    76 EMRSFTDMNFNL----YKLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLL 136
            |...|.|:..|:    ..|.:::|||..|....|..|:.:.:|.:..|.:..:.:.|
Zfish    44 ESGGFQDVPENISLGCQGLSLRYNSLLLLLPYQFAHLNQLVWLYLDHNSISTVDRLA-------- 100

  Fly   137 TLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQLESLNGSLHDL 201
                            |:|::|:..|||.||.|.:|..|:|.                  ::.:|
Zfish   101 ----------------FQGLRRLKELILSSNKIAQLQNGTFE------------------TVPNL 131

  Fly   202 HNLESLFINANNITSLDDELPDGGQLRLLMAHNNRLERLPANMAGMHSLETVHIHCNQLRSFDRV 266
            .||:                         :::|...:.:|.:..|:..|:.:|:..|.:||
Zfish   132 RNLD-------------------------LSYNQMQDLVPGHFHGLRKLQNLHLRSNNIRS---- 167

  Fly   267 LRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIKSL-NSSLLPILKLKNANFSFNDI 330
                               :....|..|..:|.|.:|.|.:::: .::.|.:|:|
Zfish   168 -------------------IPVRTFMECRSLEFLDLGYNRLRTITRTTFLGLLRL---------- 203

  Fly   331 EEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQELMLVNLDLDNNRIDSLNGAL-AGLGNLRI 394
                 .|||                                  |::|:...:|..| ..|.||:.
Zfish   204 -----TELH----------------------------------LEHNQFSRINFFLFPRLLNLQA 229

  Fly   395 LNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYNNITKLEQDFKG 459
            |.|..||:..:..|.......|..|||:||::..|.|.....||:|..|
Zfish   230 LYLQWNRIRTVVQGSPWTWHTLQKLDLSGNEIQILDPAIFRCLPNLHTL---------------- 278

  Fly   460 LPVLCQANLTNNQISTISSELVTN-TRCKNHNVPGKLEIHLDDNPIMCDVGLNELCRLMAVQEAR 523
                   ||.:|:||.:|.|:|:: ......|:.|.:   .|.:..:|.: ::.|......::|.
Zfish   279 -------NLESNKISNVSLEVVSSWISISTINLAGNI---WDCSSSICPL-VSWLRNFRGTRDAS 332

  Fly   524 IRGRSQCFENDQEVCTVLPMLYNVNLPIMVTNLKLTGREVPKPMVRVIVPSLIKANNELLPPLIA 588
            |            :|:              |...|.|..| ...||         ||.:...:..
Zfish   333 I------------ICS--------------TPKSLQGERV-MDAVR---------NNSVCEEMFT 361

  Fly   589 TLGNPVLISTDLVNPVISPLPPPLLLATTTPPPPLPLPVESEVEKNESTTANPVPTNYTQETTTT 653
                 |..:|:|.          |||.|||                        .|.|..:..||
Zfish   362 -----VEPTTELT----------LLLTTTT------------------------TTLYVTKPPTT 387

  Fly   654 TSTTTTTTTTETSSQVAPIEIITTTAPTTTTTSTTTPKPNETLPVIVELQDPNPPDTTVNQTALV 718
            | |||..|||...|||..|:.:|               |...|||     .|.....||..::|
Zfish   388 T-TTTPRTTTRQLSQVTHIQRLT---------------PKVLLPV-----RPEKEFLTVTPSSL- 430

  Fly   719 PPVVLDP-----------------------------------------LQQDLEREREREREREL 742
             |...:|                                         |||...|.:.|::.||.
Zfish   431 -PFTPEPEFEHMTFHKIIAGSVALFLSVSLILLVIYVSWRRYPNSMRQLQQHSIRRKRRKKTREP 494

  Fly   743 ERDLDHEAVAKTEY---------ETVEYIPN 764
            |.:::.:.   .||         ||::.:.|
Zfish   495 EHNINSQL---QEYYLSYNHANAETMDSLVN 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	78/405 (19%)
		leucine-rich repeat	65..86	CDD:275380	3/9 (33%)
		leucine-rich repeat	87..110	CDD:275380	7/26 (27%)
		leucine-rich repeat	111..134	CDD:275380	3/22 (14%)
		leucine-rich repeat	135..158	CDD:275380	2/22 (9%)
		leucine-rich repeat	159..180	CDD:275380	9/20 (45%)
		leucine-rich repeat	181..203	CDD:275380	1/21 (5%)
		leucine-rich repeat	204..226	CDD:275380	1/21 (5%)
		leucine-rich repeat	227..249	CDD:275380	3/21 (14%)
		leucine-rich repeat	250..272	CDD:275380	5/21 (24%)
		leucine-rich repeat	273..296	CDD:275380	2/22 (9%)
		leucine-rich repeat	297..315	CDD:275380	4/18 (22%)
		leucine-rich repeat	320..335	CDD:275378	1/14 (7%)
		leucine-rich repeat	344..366	CDD:275380	0/21 (0%)
		leucine-rich repeat	367..391	CDD:275380	5/24 (21%)
		leucine-rich repeat	392..415	CDD:275380	6/22 (27%)
		leucine-rich repeat	416..439	CDD:275380	9/22 (41%)
		leucine-rich repeat	440..462	CDD:275380	2/21 (10%)
		leucine-rich repeat	463..483	CDD:275380	8/19 (42%)
lrrtm4l2	XP_009302017.1	LRR	<77..>308	CDD:443914	74/392 (19%)
		leucine-rich repeat	83..106	CDD:275380	5/46 (11%)
		leucine-rich repeat	107..130	CDD:275380	9/40 (23%)
		leucine-rich repeat	131..154	CDD:275380	6/47 (13%)
		leucine-rich repeat	155..178	CDD:275380	7/45 (16%)
		leucine-rich repeat	179..202	CDD:275380	5/22 (23%)
		leucine-rich repeat	203..226	CDD:275380	9/71 (13%)
		leucine-rich repeat	227..250	CDD:275380	6/22 (27%)
		leucine-rich repeat	251..274	CDD:275380	9/22 (41%)
		PCC	279..>360	CDD:188093	24/120 (20%)