Protein Alignment ltl and lrrn1

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_001124166.1
• Gene: lrrn1 / 568527
• ZFINID: ZDB-GENE-071126-1
• Length: 717
• Species: Danio rerio
• Alignment Length: 876
• Identity: 173/876 - (19%)
• Similarity: 284/876 - (32%)
• Gaps: 332/876 - (37%)

  Fly     4 LVYTVFHLASLQCSVRPEISPCTCETGKAW--------NHVELSCEKLESFNAVVDSLANKLNAD 60
            |:..|..|:|:..:..|::  |.||. :.|        ....:.|..|.     :..:...|:||
Zfish    18 LLLAVLGLSSVHSTECPQL--CVCEI-RPWFTPQSTYREATTVDCNDLH-----LTRIPGNLSAD 74

  Fly    61 TNIDLKITHSQLDDLEMRSFTDMNFNLYKLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIP 125
            |.:                          |.:|.|.:....| ....|.|:|.|.:..|:...|.
Zfish    75 TQV--------------------------LLLQSNYIARTSE-ELEQLLNLTELDLSQNNFSNIR 112

  Fly   126 KHALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQ 190
            ...|::|..|.|                                              |||..||
Zfish   113 DIGLTNMSQLTT----------------------------------------------LHLEENQ 131

  Fly   191 L-ESLNGSLHDLHNLESLFINANNITSLDDELPDGGQLRLLMAHNNRLERLPANMAGMHSLETVH 254
            : |..:.||.||.||:.|:||.|.|:|:                      .|...||:.:|..:|
Zfish   132 IVEMPDFSLQDLTNLQELYINHNQISSI----------------------APNAFAGLRNLLRLH 174

  Fly   255 IHCNQLRSFD-RVLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIKSLNSSLLPIL 318
            ::.|:|::.| |...:..||..:|...|.:             |..|.:....:.:|.|.:|
Zfish   175 LNSNRLKAIDSRWFESTPNLEILMIGENPV-------------VGILDLNFKPLTNLRSLVL--- 223

  Fly   319 KLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQELMLVNLDLDNNRIDSLN 383
                |.....||...:..   ||.:|::|....|::.|:   |:
Zfish   224 ----AGMELTDIPGNAFV---GLDNLESLSFYDNKLVRV---PQ--------------------- 257

  Fly   384 GALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLE---MTLLPSLKILKV 445
            .||..|.||:.|:|..|.:..:|.|||..|:||..|.:  |.:.||..::   :..||.|..|:
Zfish   258 TALQKLPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGI--NNMGELVSIDRFALDNLPELTKLE- 319

  Fly   446 AYNN-----ITKLEQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLEIHLDDNPIM 505
            |.||     :::|.  |:.||.|....|.||.::::       .:....::|...||.:..||:.
Zfish   320 ATNNPKFSYVSRLA--FRDLPALESLMLNNNALNSL-------YQATADSLPNLREISIHSNPLR 375

  Fly   506 CD------------VGLNELCRLMAVQEARIRGR-----------SQCFENDQEVCTVLPML--- 544
            ||            :...|...:.......:||:           .||          |||:
Zfish   376 CDCVIQWMSSNKTTIRFMEPLSMFCTMPIEVRGQRVRDVFSREPSGQC----------LPMISHD 430

  Fly   545 ---YNVNLPI-MVTNLKLTGREVPKPMVRVIVPSLIKANNELLPPLIATLGNPVLISTDLVNPVI 605
               .::||.| |..:|.......|:|.:..:.||                ||.|::.|      :
Zfish   431 TFPNHLNLDIGMTVDLDCRAMAEPEPEIYWVTPS----------------GNKVMMDT------V 473

  Fly   606 SPLPPPLLLATTTPPPPLPLPVESEVEKNESTTANPVPTNYTQETTTTTSTTTTTTTTETSSQVA 670
            |                         :|.:..:|..:..:|.|...:...|.....|....::|.
Zfish   474 S-------------------------DKYQLNSAGTLRISYIQVDDSGHYTCVAQNTEGADTRVT 513

  Fly   671 PIEIITTTAPTTTTTSTTTPKPNETLPVIVE------------------LQDPNPPDTTVNQTAL 717
            .|.:..|...:|....... |..|:..::|.                  ::..||   .:..||.
Zfish   514 AIRVNGTLLDSTQLMKIYV-KHTESHSILVSWKVNSNVMTSNLKWSSATMKIDNP---HITYTAK 574

  Fly   718 VPPVVLDPLQQDLERERERERERELERDLDHEAVAKTEYETVEYIPNLVQPPVGSDALTPPPSKA 782
            ||..|                   .|.:|.|...| ||||....:.|:.|
Zfish   575 VPVDV-------------------HEYNLTHLQPA-TEYEVCLSVSNIHQ--------------- 604

  Fly   783 NALEEDSESVHSNSVHAEYPHAAQSLQIPEE 813
                    ....:.|:....||..:::|.|:
Zfish   605 --------QTQKSCVNVTTKHATFAVEISEQ 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	94/420 (22%)
		leucine-rich repeat	65..86	CDD:275380	0/20 (0%)
		leucine-rich repeat	87..110	CDD:275380	5/22 (23%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		leucine-rich repeat	135..158	CDD:275380	2/22 (9%)
		leucine-rich repeat	159..180	CDD:275380	0/20 (0%)
		leucine-rich repeat	181..203	CDD:275380	10/22 (45%)
		leucine-rich repeat	204..226	CDD:275380	7/21 (33%)
		leucine-rich repeat	227..249	CDD:275380	3/21 (14%)
		leucine-rich repeat	250..272	CDD:275380	6/22 (27%)
		leucine-rich repeat	273..296	CDD:275380	3/22 (14%)
		leucine-rich repeat	297..315	CDD:275380	4/17 (24%)
		leucine-rich repeat	320..335	CDD:275378	3/14 (21%)
		leucine-rich repeat	344..366	CDD:275380	5/21 (24%)
		leucine-rich repeat	367..391	CDD:275380	3/23 (13%)
		leucine-rich repeat	392..415	CDD:275380	9/22 (41%)
		leucine-rich repeat	416..439	CDD:275380	6/25 (24%)
		leucine-rich repeat	440..462	CDD:275380	8/26 (31%)
		leucine-rich repeat	463..483	CDD:275380	4/19 (21%)
lrrn1	NP_001124166.1	leucine-rich repeat	55..74	CDD:275380	3/23 (13%)
		LRR	<73..375	CDD:443914	102/455 (22%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		leucine-rich repeat	122..145	CDD:275380	12/68 (18%)
		leucine-rich repeat	146..169	CDD:275380	10/44 (23%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	5/35 (14%)
		leucine-rich repeat	218..241	CDD:275380	8/32 (25%)
		leucine-rich repeat	242..265	CDD:275380	8/46 (17%)
		leucine-rich repeat	266..289	CDD:275380	9/22 (41%)
		leucine-rich repeat	290..314	CDD:275380	6/25 (24%)
		leucine-rich repeat	315..337	CDD:275380	7/24 (29%)
		leucine-rich repeat	340..353	CDD:275378	4/12 (33%)
		leucine-rich repeat	364..376	CDD:275378	4/11 (36%)
		LRRCT	372..414	CDD:214507	7/41 (17%)
		Ig	430..510	CDD:472250	20/126 (16%)
		Ig strand B	444..448	CDD:409353	1/3 (33%)
		Ig strand C	457..461	CDD:409353	0/3 (0%)
		Ig strand E	483..487	CDD:409353	0/3 (0%)
		Ig strand F	497..502	CDD:409353	1/4 (25%)
		Ig strand G	510..513	CDD:409353	0/2 (0%)
		FN3	532..601	CDD:214495	18/92 (20%)