Protein Alignment ltl and lingo1a

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: XP_005174327.1
• Gene: lingo1a / 564943
• ZFINID: ZDB-GENE-080327-16
• Length: 615
• Species: Danio rerio
• Alignment Length: 646
• Identity: 136/646 - (21%)
• Similarity: 229/646 - (35%)
• Gaps: 192/646 - (29%)

  Fly   126 KHALSHMPSLLT-----------LDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPK 179
            :..|.|...|::           ||:.:.:|:.:..::|....::..|.|..|.|:.::.|:|..
Zfish    46 RSVLCHRKKLMSVPEGIPSETRLLDLSKNRIKTINPDEFSAFPQLEELELNENTISAIEPGAFNN 110

  Fly   180 --SLLILHLGRNQLESLN-GSLHDLHNLESLFINANNITSLDDELPDGGQLRLLMAHNNRLERLP 241
              .|..|.|..|:|:.:. |....|.||..|.|:.|.|..|
Zfish   111 LYGLQTLGLRSNKLKLIQLGVFTGLSNLTKLDISENKIVIL------------------------ 151

  Fly   242 ANMAGMHSLETVHIHCNQLRSFDRVLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQM-GCN 305
                                 .|.:.::..||..:...:|:|.:::...|...|.:|.|.: .||
Zfish   152 ---------------------LDYMFQDLYNLRSLEVGDNDLVFISHRAFHGLSSLEQLTLEKCN 195

  Fly   306 ----------HIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQ------LSSNRI 354
                      |:.||.:     |:|:|.|  .|.|.::|...|:.|:.|:...      :::|.:
Zfish   196 LTSVPTEAFTHLHSLVT-----LRLRNLN--INSIRDYSFKRLYRLKVLEIANWPYLDTMTTNCL 253

  Fly   355 QRLLPDPRGVQELMLVNLDLDNNRIDSLNG-ALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDI 418
                      ..|.|.:|.:.|..:.|:.. ||..|..||.||::.|.::.::......::||..
Zfish   254 ----------YGLNLTSLTITNANLTSIPYLALRHLVYLRFLNMSYNPIQMIEGNRLHDLLRLQE 308

  Fly   419 LDLTGNQLAELKPLEMTLLPSLKILKVAYNNITKLEQDFKGLPVLCQANLTNNQISTISSELVTN 483
            |.|.|.:|:.::|.....|..||:|.|:.|.:|.||:..
Zfish   309 LYLVGGRLSVIEPYSFRGLNYLKVLNVSSNFLTTLEESV-------------------------- 347

  Fly   484 TRCKNHNVPGKLE-IHLDDNPIMCDVGLNELCRLMAVQEARIRGRSQCFENDQEVCTVLPMLY-- 545
                .|:| |.|| :.|.|||:.||      |||:.|...|.|..   |...|..|:....:.
Zfish   348 ----FHSV-GNLETLALHDNPLACD------CRLLWVFRRRWRLN---FNRQQPTCSSPEFVQGK 398

  Fly   546 ------NVNLPIMVTNLKLTGREVPKPMVRVI-----VPSLIKANNELLPPLIATLGNPVLISTD 599
                  ::..|...|..|...|: .||..:.:     |..:.:|:           |:|
Zfish   399 EFKDFPDILQPNYFTCRKSRIRD-RKPQQKFVDEGTTVHFVCQAD-----------GDP------ 445

  Fly   600 LVNPVISPLPPPLLLATTTPPPPLPLPVESEVEKNESTTANPVPTNYTQETTTTTSTTTTTTTTE 664
              .|||..|.|.....|......|.:..:..:|           ..|.|.....|.....:....
Zfish   446 --TPVIMWLSPQKQFITMKTIGRLTVFPDGTLE-----------VRYAQIQDNGTYGCIASNAGG 497

  Fly   665 TSSQVAPIEIITTTAPTTTTTSTTTP-KPNETLPVIVELQDPNPPDTTVNQTALVPPVVLD 724
            ..:.:|.:.:        .:.|...| :||:||..|    ...|.|.::|:|....|...|
Zfish   498 NDTALAHLHV--------HSYSPDWPNQPNKTLAFI----SNQPNDNSINETRATVPFPFD 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	81/381 (21%)
		leucine-rich repeat	65..86	CDD:275380
		leucine-rich repeat	87..110	CDD:275380
		leucine-rich repeat	111..134	CDD:275380	2/7 (29%)
		leucine-rich repeat	135..158	CDD:275380	5/33 (15%)
		leucine-rich repeat	159..180	CDD:275380	6/22 (27%)
		leucine-rich repeat	181..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..226	CDD:275380	6/21 (29%)
		leucine-rich repeat	227..249	CDD:275380	0/21 (0%)
		leucine-rich repeat	250..272	CDD:275380	1/21 (5%)
		leucine-rich repeat	273..296	CDD:275380	4/22 (18%)
		leucine-rich repeat	297..315	CDD:275380	7/28 (25%)
		leucine-rich repeat	320..335	CDD:275378	5/14 (36%)
		leucine-rich repeat	344..366	CDD:275380	2/27 (7%)
		leucine-rich repeat	367..391	CDD:275380	8/24 (33%)
		leucine-rich repeat	392..415	CDD:275380	5/22 (23%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..462	CDD:275380	8/21 (38%)
		leucine-rich repeat	463..483	CDD:275380	0/19 (0%)
lingo1a	XP_005174327.1	LRRNT	34..68	CDD:214470	3/21 (14%)
		leucine-rich repeat	66..89	CDD:275380	4/22 (18%)
		LRR	<69..>279	CDD:443914	56/271 (21%)
		leucine-rich repeat	90..113	CDD:275380	6/22 (27%)
		leucine-rich repeat	114..137	CDD:275380	7/22 (32%)
		leucine-rich repeat	138..185	CDD:275380	12/91 (13%)
		leucine-rich repeat	186..209	CDD:275380	5/22 (23%)
		leucine-rich repeat	210..257	CDD:275380	12/63 (19%)
		leucine-rich repeat	234..256	CDD:275380	3/31 (10%)
		leucine-rich repeat	258..281	CDD:275380	7/22 (32%)
		leucine-rich repeat	282..305	CDD:275380	5/22 (23%)
		LRR_8	305..364	CDD:404697	24/89 (27%)
		leucine-rich repeat	306..329	CDD:275380	7/22 (32%)
		leucine-rich repeat	330..350	CDD:275380	8/49 (16%)
		PCC	334..>416	CDD:188093	27/121 (22%)
		Ig	416..507	CDD:472250	20/121 (17%)
		Ig strand B	435..439	CDD:409353	1/3 (33%)
		Ig strand C	448..452	CDD:409353	2/3 (67%)
		Ig strand E	473..477	CDD:409353	1/14 (7%)
		Ig strand F	487..492	CDD:409353	1/4 (25%)
		Ig strand G	500..503	CDD:409353	0/2 (0%)