Protein Alignment ltl and lgr4

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_001340791.1
• Gene: lgr4 / 558825
• ZFINID: ZDB-GENE-111013-1
• Length: 971
• Species: Danio rerio
• Alignment Length: 578
• Identity: 135/578 - (23%)
• Similarity: 246/578 - (42%)
• Gaps: 115/578 - (19%)

  Fly    74 DLEMRSFTDMNFNLYK-------LRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSH 131
            |:.|.:.|::..|:::       ||:..|.|..:......||..:..|.:.:|.|..:|..||.:
Zfish    66 DISMNNITELPANVFRNLPYLEELRLAGNDLAFIHPEALSGLHQLKVLMLQNNQLKTVPSAALKN 130

  Fly   132 MPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQLESLNG 196
            :.:|.:|.:....|.:|.::.|.|:|::.:|.|..|.:|.:     |.|.|       |.:|
Zfish   131 LNALQSLRLDANHITSVPEDSFEGLQQLRHLWLDDNSLTEV-----PISPL-------QHQS--- 180

  Fly   197 SLHDLHNLESLFINANNITSL-DDELPDGGQLRLLMAHNNRLERLPAN-MAGMHSLETVHIHCNQ 259
                  ||::|.:..|.||.: |:...:...|.:|..||||::.:..| ..|:.:|||:.::.|.
Zfish   181 ------NLQALTLALNRITHIPDNAFANLSSLVVLHLHNNRIQEIGKNCFNGLDNLETLDLNFNN 239

  Fly   260 LRSFDRVLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIKSL------NSSLLPIL 318
            |:.|...::....|.|:...:|.:..:.:..|...|.:.|:.:..|.:..:      |.|.|..|
Zfish   240 LKIFPEAIQMLPKLKELGFHSNNIASIPEGAFCRNSLLRTIHLFDNPLSFVGTTAFQNLSDLHSL 304

  Fly   319 KLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQELMLVNLDLDNNRIDSLN 383
            .|:.|:.    :::|  ..|.|..:|::|.|:..:| |.:|........:|..:||..|.|:.|
Zfish   305 MLRGASM----MQDF--PSLTGTINLESLTLTGTKI-RSIPADLCEDLTVLRTVDLSYNDIEDL- 361

  Fly   384 GALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYN 448
            .:..|...|:.:||..|:::.:..|.|.||..|.:|||:.||:..:.......|.:|..|.::.|
Zfish   362 PSFQGCVRLQDINLQHNQIKQIDRGTFQGMTSLRVLDLSRNQIKFIHRDAFLSLSALTNLDLSLN 426

  Fly   449 NITKLEQDFKGLPVLCQANLTNNQISTISSELVTNT--RCKNHNVPGKLEIHLDDNPIMCDVGLN 511
            ::..:..  .||..|.|..||.|.  .:.:.|::.|  :.::..||...:         |
Zfish   427 SLASVPT--AGLSALNQLKLTGNM--ELRNGLMSKTLPKLRSITVPYAYQ---------C----- 473

  Fly   512 ELCRLM----AVQEARIRGRSQCFENDQEV--------CTVLPMLYNVNLPIMVTNLKLTGREVP 564
              |..:    ||..|....|...|..::::        |:.||..:
Zfish   474 --CAFVAYDSAVNPAEDDERRNAFGGEEDMERIPMVMHCSPLPGAF------------------- 517

  Fly   565 KP--------MVRVIVPSLIKANNELLPPLIATLGNPVLISTDLVNPVISPLPPPLLL 614
            ||        |:|:.|..:.         |:|.|.|.::::... :|..|.|.|...|
Zfish   518 KPCEHLLGSWMIRLTVWFIC---------LVALLFNCLVLAATF-SPRTSSLSPSRFL 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	107/416 (26%)
		leucine-rich repeat	65..86	CDD:275380	3/11 (27%)
		leucine-rich repeat	87..110	CDD:275380	6/29 (21%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..180	CDD:275380	5/20 (25%)
		leucine-rich repeat	181..203	CDD:275380	3/21 (14%)
		leucine-rich repeat	204..226	CDD:275380	6/22 (27%)
		leucine-rich repeat	227..249	CDD:275380	8/22 (36%)
		leucine-rich repeat	250..272	CDD:275380	6/21 (29%)
		leucine-rich repeat	273..296	CDD:275380	4/22 (18%)
		leucine-rich repeat	297..315	CDD:275380	4/23 (17%)
		leucine-rich repeat	320..335	CDD:275378	3/14 (21%)
		leucine-rich repeat	344..366	CDD:275380	6/21 (29%)
		leucine-rich repeat	367..391	CDD:275380	7/23 (30%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..462	CDD:275380	5/21 (24%)
		leucine-rich repeat	463..483	CDD:275380	6/19 (32%)
lgr4	NP_001340791.1	LRR 1	58..82		4/15 (27%)
		leucine-rich repeat	64..85	CDD:275380	4/18 (22%)
		LRR 2	84..106		4/21 (19%)
		LRR	85..>452	CDD:443914	103/399 (26%)
		leucine-rich repeat	86..109	CDD:275380	6/22 (27%)
		LRR 3	107..130		7/22 (32%)
		leucine-rich repeat	110..133	CDD:275380	6/22 (27%)
		LRR 4	131..154		5/22 (23%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		LRR 5	156..178		8/33 (24%)
		leucine-rich repeat	158..181	CDD:275380	9/43 (21%)
		LRR 6	179..202		8/31 (26%)
		leucine-rich repeat	182..205	CDD:275380	6/22 (27%)
		LRR 7	204..226		7/21 (33%)
		leucine-rich repeat	206..229	CDD:275380	8/22 (36%)
		LRR 8	227..250		6/22 (27%)
		leucine-rich repeat	230..252	CDD:275380	6/21 (29%)
		LRR 9	251..273		4/21 (19%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		LRR 10	275..297		3/21 (14%)
		leucine-rich repeat	277..298	CDD:275380	2/20 (10%)
		LRR 11	299..321		7/27 (26%)
		LRR 12	322..344		6/22 (27%)
		LRR 13	345..366		6/21 (29%)
		leucine-rich repeat	348..369	CDD:275380	7/21 (33%)
		LRR 14	367..390		6/22 (27%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		LRR 15	391..414		7/22 (32%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		LRR 16	416..438		5/23 (22%)
		leucine-rich repeat	418..438	CDD:275380	5/21 (24%)
		7tmA_LGR4	527..811	CDD:320483	12/49 (24%)
		TM helix 1	528..554	CDD:320483	7/35 (20%)
		TM helix 2	562..587	CDD:320483	1/4 (25%)
		TM helix 3	607..637	CDD:320483
		TM helix 4	649..679	CDD:320483
		TM helix 5	698..727	CDD:320483
		TM helix 6	736..766	CDD:320483
		TM helix 7	779..804	CDD:320483