Protein Alignment ltl and LRRN3

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_060804.3
• Gene: LRRN3 / 54674
• HGNCID: 17200
• Length: 708
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 129/546 - (23%)
• Similarity: 219/546 - (40%)
• Gaps: 141/546 - (25%)

  Fly   100 LPEVPFR-----GLSNVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKI------RAVQQE-- 151
            :.::|.|     ||:..|.:...|..:|         .|.|.|     |:|      |::..|
Human     1 MKDMPLRIHVLLGLAITTLVQAVDKKVD---------CPRLCT-----CEIRPWFTPRSIYMEAS 51

  Fly   152 --DFRGIQRVT----------NLILVSNIITRLDRGS-FPKSLLILHLGRNQLESL-NGSLHDLH 202
              |...:..:|          .|:|.:|.|.:::..: ||.:|..|.|.:|.|.|: |.::..:.
Human    52 TVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMP 116

  Fly   203 NLESLFINANNITSLDDE-LPDGGQLRLLMAHNNRLERL-PANMAGMHSLETVHIHCNQLRSFDR 265
            .|.|:::..|.:|.|.:: |.:...|:.|..::|.|..: |....|:|:|..:|:
Human   117 QLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHL---------- 171

  Fly   266 VLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIKSLNSSLLPILKLKNANFSFNDI 330
                         ::|.|:.:....|.:...:|.|.:|.|          ||:::|:.||.
Human   172 -------------NSNRLQMINSKWFDALPNLEILMIGEN----------PIIRIKDMNFK---- 209

  Fly   331 EEFSMAELHGLRSLKTLQLSSNRIQRLLPDPR--GVQELMLVNLDLDNNRIDSLNGALAGLGNLR 393
                  .|..||||....::...|    ||..  |::.|..::. .||..|...:.||..:.||:
Human   210 ------PLINLRSLVIAGINLTEI----PDNALVGLENLESISF-YDNRLIKVPHVALQKVVNLK 263

  Fly   394 ILNLAGNRLEHLQVGDFDGMIRLDILDLTG-NQLAELKPLEMTLLPSLKILKVAYNNITKLE--- 454
            .|:|..|.:..::.|||..|:.|..|.:.. .:|..:..|.:..||.|:  |:...|..:|.
Human   264 FLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLR--KIEATNNPRLSYIH 326

  Fly   455 -QDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLEIHLDDNPIMCD-----VGLN-- 511
             ..|..||.|....|.:|.:|.:....:       .::|...||.:..|||.||     :.:|
Human   327 PNAFFRLPKLESLMLNSNALSALYHGTI-------ESLPNLKEISIHSNPIRCDCVIRWMNMNKT 384

  Fly   512 -----ELCRLMAVQEARIRG---RSQCFENDQEVCTVLPMLYNVNLPIMVTNLKL-TGREV---- 563
                 |...|..|.....:|   |...|.:..|:|  ||::...:.|   :||.: .|..|
Human   385 NIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEIC--LPLIAPESFP---SNLNVEAGSYVSFHC 444

  Fly   564 -----PKPMVRVIVPSLIKANNELLP 584
                 |:|.:..|.||    ..:|||
Human   445 RATAEPQPEIYWITPS----GQKLLP 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	97/411 (24%)
		leucine-rich repeat	65..86	CDD:275380
		leucine-rich repeat	87..110	CDD:275380	4/14 (29%)
		leucine-rich repeat	111..134	CDD:275380	3/22 (14%)
		leucine-rich repeat	135..158	CDD:275380	7/32 (22%)
		leucine-rich repeat	159..180	CDD:275380	7/31 (23%)
		leucine-rich repeat	181..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..226	CDD:275380	6/22 (27%)
		leucine-rich repeat	227..249	CDD:275380	6/22 (27%)
		leucine-rich repeat	250..272	CDD:275380	2/21 (10%)
		leucine-rich repeat	273..296	CDD:275380	3/22 (14%)
		leucine-rich repeat	297..315	CDD:275380	4/17 (24%)
		leucine-rich repeat	320..335	CDD:275378	3/14 (21%)
		leucine-rich repeat	344..366	CDD:275380	5/23 (22%)
		leucine-rich repeat	367..391	CDD:275380	6/23 (26%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	5/23 (22%)
		leucine-rich repeat	440..462	CDD:275380	6/25 (24%)
		leucine-rich repeat	463..483	CDD:275380	4/19 (21%)
LRRN3	NP_060804.3	LRRNT	28..72	CDD:214470	10/57 (18%)
		LRR	<69..354	CDD:443914	81/334 (24%)
		LRR 1	70..91		4/20 (20%)
		leucine-rich repeat	72..93	CDD:275380	6/20 (30%)
		LRR 2	93..114		7/20 (35%)
		leucine-rich repeat	94..117	CDD:275380	7/22 (32%)
		LRR 3	117..138		6/20 (30%)
		leucine-rich repeat	118..141	CDD:275380	6/22 (27%)
		LRR 4	141..162		5/20 (25%)
		leucine-rich repeat	142..165	CDD:275380	6/22 (27%)
		LRR 5	165..186		5/43 (12%)
		leucine-rich repeat	166..189	CDD:275380	5/45 (11%)
		LRR 6	189..210		9/40 (23%)
		leucine-rich repeat	190..213	CDD:275380	10/42 (24%)
		LRR 7	213..234		7/24 (29%)
		leucine-rich repeat	214..237	CDD:275380	8/26 (31%)
		LRR 8	237..258		6/21 (29%)
		leucine-rich repeat	238..261	CDD:275380	6/23 (26%)
		LRR 9	261..282		8/20 (40%)
		leucine-rich repeat	262..285	CDD:275380	8/22 (36%)
		LRR 10	285..304		3/18 (17%)
		leucine-rich repeat	286..310	CDD:275380	5/23 (22%)
		LRR 11	310..332		5/23 (22%)
		leucine-rich repeat	311..333	CDD:275380	5/23 (22%)
		LRR 12	335..358		4/29 (14%)
		leucine-rich repeat	336..359	CDD:275380	4/29 (14%)
		PCC	341..>442	CDD:188093	27/112 (24%)
		Ig	421..513	CDD:472250	14/53 (26%)
		Ig strand B	440..444	CDD:409353	1/3 (33%)
		Ig strand C	453..457	CDD:409353	0/3 (0%)
		Ig strand E	479..483	CDD:409353
		Ig strand F	493..498	CDD:409353
		Ig strand G	506..509	CDD:409353
		fn3	526..593	CDD:394996