DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ltl and kek6

DIOPT Version :9

Sequence 1:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	910	Identity:	159/910 - (17%)
Similarity:	294/910 - (32%)	Gaps:	281/910 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LVYTVFHLASLQCSVRPEISPCTCETGKAWNHVELS--CEKLESFNAVVDSLANKLNADTNIDLK 66
            :.:||....||.|:     |.|||:    |.:.:.|  |..|:     :.::.|.|:.:..: |.
  Fly    26 VAWTVADDWSLSCA-----SNCTCK----WTNGKKSAICSSLQ-----LTTIPNTLSTELQV-LV 75

  Fly    67 ITHSQLDDLEMRSFTDMNFNLYKLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSH 131
            :..:.:..|....|:.:                       ||.|:..:.:..:::..|.|.:..:
  Fly    76 LNDNHIPYLNREEFSTL-----------------------GLLNLQRIYLKKSEVQYIHKESFRN 117

  Fly   132 MPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQLESLNG 196
            :..|:.:|:...|:..:.::.|.|..|:..|.|..|.:.||....||   ::.|     |.:|
  Fly   118 LKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLAAYQFP---ILPH-----LRTL-- 172

  Fly   197 SLHDLHNLESLFINANNITSLDDELPDGGQLRLLMAHNNRLERLPANMAGMHSLETVHIHCNQLR 261
               |:|:....:|:                              |.::|.::.||.:::
  Fly   173 ---DMHDCLISYID------------------------------PMSLANLNLLEFLNL------ 198

  Fly   262 SFDRVLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQM-----GCN---------HIKSLNS 312
                             .||.||.|::..|...:.::||.:     .||         ::.|..|
  Fly   199 -----------------KNNLLESLSEYVFQHMANLKTLSLEENPWQCNCKLRKFRGWYVNSRLS 246

  Fly   313 SLLPILK----LKNANFSFNDIEEFS---MAELHGLRSLKTLQLSSNRIQRLL----PDPRGVQE 366
            |:..:.|    .|:..:...|.|.|.   ..|:.....::.:.:.||.....|    |.|....|
  Fly   247 SVSLVCKGPPAQKDRTWDSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWE 311

  Fly   367 LMLVNLDLDNNRIDSLNGALAGL-GNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGN---QLA 427
            |....||.||...:|.:.|...| .||.:.|:..     |..|.:.......|..:|.|   .|:
  Fly   312 LNGKILDNDNVLFESESIASDKLWSNLTVFNVTS-----LDAGTYACTGSNSIGSMTQNISIYLS 371

  Fly   428 EL--KPLEMT------------------LLPSLKILKVAYNNITKLEQDFKGLPVLCQANLTNNQ 472
            |:  ..||.|                  ||.|:..:.......|:..:......|....:..:.:
  Fly   372 EIVQHVLEKTPETFWYFGLIMGIFGTVFLLISISFVVCLCKRTTRQHRHANKAGVKSSVSFNDQE 436

  Fly   473 ISTISSELVTNTRCKN-----HNVPGKLEIHLDDNPIMCDVGLNELCRLMAV------------- 519
            ...:.|.:.|.|..:.     .|.|..:.::..|:   ..:|.|:: .:.||
  Fly   437 KKLLDSSVTTTTNDRGDSYGIDNQPTSIGMNKGDS---AGMGFNQI-EIHAVESHRHGSMLVQQQ 497

  Fly   520 -QEARIRG----RSQCFENDQEVCTVLPMLYNVNLPIMVTNLKLTGREVPKPMVRVIVPSLIKAN 579
             |:.::.|    |.|..:.....|.::.                             ||:.:..:
  Fly   498 PQQQQVAGGGGMRQQLMQVKDSTCGMMS-----------------------------VPTSMAGH 533

  Fly   580 NELLPPLIATLGNPVLISTDL-VNPVISPLPPPLLLATTTPPPP------LPLPVESEVEKNEST 637
            ..         .:|..||.:. :|..:.| |||...:...|.|.      :.:.|..::......
  Fly   534 AH---------SHPAQISEEFPLNVGVFP-PPPEFCSNIVPNPAFGGNIFIRVSVTQDMLDGADL 588

  Fly   638 TANPVPTNYTQETTTTTSTTTTTTTTETSSQVAPIEIITTTAPTTTTTSTTTPKPNETLPVIVEL 702
            ...|...|..:.......:        .:..||..|....|.|..|.......|
  Fly   589 NMYPDLLNIPKRMQDVQES--------GAGAVAVPEGQFATLPRHTARRGILKK----------- 634

  Fly   703 QDPNPPDTTVNQTALVPPVVLDPLQQDLERERERERERELERD------LDHEAVAKTEYETVEY 761
                  ||::.|............||..:::.::::.::|::.      ..|:.:.....|...|
  Fly   635 ------DTSLQQQQQQHQQQHQHQQQQQQQQIQQQQHQQLQQQHQPSGLYTHDEIVTYNLEASGY 693

  Fly   762 IPNLVQPPVGSDAL----TPPPSKANALEEDSESVHSNSVHA-----EYPHAAQSLQIPEEPPEE 817
            .|:  |....|:|:    .|||....|:.:......:|....     ..|.|.||      ||.|
  Fly   694 DPH--QSGYHSNAMELPPPPPPPAVTAVVQCHHPSPNNCASCINNAPPPPSACQS------PPVE 750

Fly 818 817
Fly 751 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	3/20 (15%)
		LRR_8	86..145	CDD:290566	7/58 (12%)
		leucine-rich repeat	87..110	CDD:275380	2/22 (9%)
		leucine-rich repeat	111..134	CDD:275380	2/22 (9%)
		leucine-rich repeat	135..158	CDD:275380	5/22 (23%)
		LRR_8	158..214	CDD:290566	14/55 (25%)
		leucine-rich repeat	159..180	CDD:275380	7/20 (35%)
		leucine-rich repeat	181..203	CDD:275380	4/21 (19%)
		leucine-rich repeat	204..226	CDD:275380	1/21 (5%)
		LRR_RI	226..451	CDD:238064	53/273 (19%)
		leucine-rich repeat	227..249	CDD:275380	2/21 (10%)
		leucine-rich repeat	250..272	CDD:275380	2/21 (10%)
		leucine-rich repeat	273..296	CDD:275380	6/22 (27%)
		leucine-rich repeat	297..315	CDD:275380	7/31 (23%)
		LRR_8	319..402	CDD:290566	23/94 (24%)
		leucine-rich repeat	320..335	CDD:275378	4/17 (24%)
		leucine-rich repeat	344..366	CDD:275380	5/25 (20%)
		leucine-rich repeat	367..391	CDD:275380	8/24 (33%)
		LRR_8	369..426	CDD:290566	15/60 (25%)
		leucine-rich repeat	392..415	CDD:275380	4/22 (18%)
		leucine-rich repeat	416..439	CDD:275380	10/45 (22%)
		LRR_8	438..>479	CDD:290566	3/40 (8%)
		leucine-rich repeat	440..462	CDD:275380	1/21 (5%)
		leucine-rich repeat	463..483	CDD:275380	1/19 (5%)
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	5/48 (10%)
		LRR_8	96..155	CDD:290566	12/58 (21%)
		leucine-rich repeat	97..120	CDD:275380	2/22 (9%)
		leucine-rich repeat	121..144	CDD:275380	5/22 (23%)
		LRR_4	144..186	CDD:289563	15/84 (18%)
		leucine-rich repeat	145..168	CDD:275380	7/25 (28%)
		leucine-rich repeat	169..216	CDD:275380	15/104 (14%)
		LRRCT	225..274	CDD:214507	10/48 (21%)
		Ig	295..367	CDD:143165	20/76 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453736
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930