DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ltl and 2mit

DIOPT Version :10

Sequence 1:NP_729265.1 Gene:ltl / 38845 FlyBaseID:FBgn0268063 Length:817 Species:Drosophila melanogaster
Sequence 2:NP_001262529.1 Gene:2mit / 41616 FlyBaseID:FBgn0260793 Length:1155 Species:Drosophila melanogaster


Alignment Length:945 Identity:198/945 - (20%)
Similarity:332/945 - (35%) Gaps:309/945 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 NHVELSCEKLESFNAVVDSLANKLNADTNIDLKITHSQLDDLEMRSFTDMNFN-LYKLRMQWNSL 97
            |.:.|:...|.:||:............|.:||  :.:||:.|.:.     ||| |.:|.:..|||
  Fly    97 NKLNLTHRDLRTFNSTGGQWKGDFQVITAMDL--SSNQLESLSLD-----NFNQLRQLDLGNNSL 154

  Fly    98 KSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDF-RGIQRVTN 161
            :.:|            ||:.|.::.         :| .:|||:...|...:....| :.:.::.|
  Fly   155 EVIP------------LSLADTNMS---------LP-FVTLDLSCNKFSQISTSFFAQRLPQLKN 197

  Fly   162 LILVSNIITRLDRGSFPKSLLILHLGRNQLESLNGSLHDLHNLESLFINANNITSLDDE----LP 222
            |.|..|.:..:.|.||                     ::|..|::|.::.|||:.:|.|    ||
  Fly   198 LNLAHNELLNISRESF---------------------YNLLELQTLVLSHNNISDIDYETFLALP 241

  Fly   223 DGGQLRLLMAHNNRLERLPAN-MAGMHSLETVHIHCN-----QLRSFDRVLRNAVNLSEVMADNN 281
            :   |:.|...:|||...... :.|:..|.::.|..|     .::.|..    :.:|.|:.|...
  Fly   242 N---LQYLDLSHNRLSGSAIRALQGIPDLVSLSIAYNPDVGVAMQEFVA----SWSLKELDASGT 299

  Fly   282 ELEYLAQDEFASCSKVETLQMGCNHIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKT 346
            .   |.|...|....|.||::..|.:|::|.               .|::.:.:        |:.
  Fly   300 G---LCQVPAALAQSVRTLKLSDNWLKAINC---------------GDMDSYPL--------LQY 338

  Fly   347 LQLSSNRIQRLLPDPRGVQELMLVNLDLDNNRIDSLNGALAGLGNLRILNLAGNRLEHLQVGDFD 411
            |.||.:||.::..|..|..|| |.:|.||.|.:..:..:|.  .:|..|.|..|::..|....|.
  Fly   339 LDLSHSRIAQVEDDALGRLEL-LESLFLDRNLLMRVPSSLP--PSLEHLFLQHNQIMELPPQAFV 400

  Fly   412 GMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYNNITKLEQDFKGLPVLCQANLTNNQISTI 476
            |::.|..|||:.|:|..|.||                          .||.|...||.::.:.::
  Fly   401 GLVNLQTLDLSNNRLIFLPPL--------------------------SLPKLLTLNLESSGVESV 439

  Fly   477 SSELVTNTRCKNHNVPGKLEIHLDDNPIMCD--VGLNEL---CRLMAVQE---ARIRGR------ 527
            |..:|       |.:|...::.|:||||.|.  :|:.|.   ||.:...:   |.:.||      
  Fly   440 SQSIV-------HTLPQLRDLLLEDNPIKCSDLLGIAEWASPCRSVDAGQSNGASVSGRVDLKTE 497

  Fly   528 ----SQCFEN-DQEVCTVLPMLYNVNLP-IMVTNLKLTGREVPKPMVRV---------------- 570
                ...:|| ....|.:.....:...| ..:|....|....|:.|.:|                
  Fly   498 YLQFHNFYENFSSRECGIRKPENDTKPPSCSLTRASATLTTTPRSMSKVEKSQEAQATATSVEVA 562

  Fly   571 ------------------------------IVPSLIKANNELLPPL-----IATLGN-PVLISTD 599
                                          .:.:...::....|.|     |.:.|| |..::|.
  Fly   563 AATAATSEKTGIQATSAAQSTAAATTAEREAIATATSSDTTATPTLAAAAAIQSAGNIPAQLTTK 627

  Fly   600 LVNPV----ISPL----PPPLLLATTTPPPPLPLPVESEVEKNESTTANPV---------PTNYT 647
            .:.|.    ::.|    ..|.:.|.||..|...||   .:.:.::|||.|:         .|...
  Fly   628 TLRPTETTSLAQLQRRQQMPGMPAKTTETPAKNLP---SLAQTKATTALPILATRDAATATTEIN 689

  Fly   648 QETTTTTSTTTTTTTTETSSQVAP--IEIITTTA--------------------PTTTTTS--TT 688
            .:..|..|..|.|..|..:....|  ||:..|..                    ||..|:.  .|
  Fly   690 SDKPTNISGATKTVATSAAEIATPPAIEVPQTILAGKKSDKMPADKAHETLLKYPTRDTSGQVAT 754

  Fly   689 TPKPNETL------------PVIVELQDPNPPDTTVNQTALVPPV---------VLDPLQQDLER 732
            ||..:.||            |:::...|....|.   :..|:|..         ||||.||....
  Fly   755 TPHKHATLQLHVKDRHLIGTPLLMHKGDVLLVDA---EQLLLPGTATVADADSEVLDPSQQHQSA 816

  Fly   733 ERERERERELERDLDHEAVAKTEYETVEYIPNLVQPPVGSDALTPPPSKAN-------------A 784
            |:|:.:....:|..|                     .:..|  |..|:|.:             :
  Fly   817 EQEKHQSATDKRQAD---------------------AINGD--TKSPAKGHKKKPSLSIKKMTYS 858

  Fly   785 LEEDSESVHSNSVHAEYP-HAAQSLQIPEE-PPEE 817
            .:..:::|...:..::.| |...|:..|:| .|||
  Fly   859 TKHAAKTVEDMAATSKTPQHQHSSVNTPKEAAPEE 893

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ltlNP_729265.1 LRR 65..476 CDD:443914 99/422 (23%)
leucine-rich repeat 65..86 CDD:275380 5/20 (25%)
leucine-rich repeat 87..110 CDD:275380 6/22 (27%)
leucine-rich repeat 111..134 CDD:275380 3/22 (14%)
leucine-rich repeat 135..158 CDD:275380 5/23 (22%)
leucine-rich repeat 159..180 CDD:275380 7/20 (35%)
leucine-rich repeat 181..203 CDD:275380 1/21 (5%)
leucine-rich repeat 204..226 CDD:275380 9/25 (36%)
leucine-rich repeat 227..249 CDD:275380 6/22 (27%)
leucine-rich repeat 250..272 CDD:275380 4/26 (15%)
leucine-rich repeat 273..296 CDD:275380 6/22 (27%)
leucine-rich repeat 297..315 CDD:275380 6/17 (35%)
leucine-rich repeat 320..335 CDD:275378 1/14 (7%)
leucine-rich repeat 344..366 CDD:275380 8/21 (38%)
leucine-rich repeat 367..391 CDD:275380 7/23 (30%)
leucine-rich repeat 392..415 CDD:275380 7/22 (32%)
leucine-rich repeat 416..439 CDD:275380 9/22 (41%)
leucine-rich repeat 440..462 CDD:275380 1/21 (5%)
leucine-rich repeat 463..483 CDD:275380 5/19 (26%)
2mitNP_001262529.1 LRR <106..458 CDD:443914 109/470 (23%)
leucine-rich repeat 124..143 CDD:275380 8/25 (32%)
leucine-rich repeat 144..167 CDD:275380 9/34 (26%)
leucine-rich repeat 172..194 CDD:275380 5/21 (24%)
leucine-rich repeat 195..218 CDD:275380 8/43 (19%)
leucine-rich repeat 219..242 CDD:275380 8/22 (36%)
leucine-rich repeat 243..311 CDD:275380 16/74 (22%)
leucine-rich repeat 312..335 CDD:275380 7/37 (19%)
leucine-rich repeat 336..359 CDD:275380 8/22 (36%)
leucine-rich repeat 360..380 CDD:275380 6/21 (29%)
leucine-rich repeat 381..404 CDD:275380 7/22 (32%)
leucine-rich repeat 405..449 CDD:275380 17/76 (22%)

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