DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ltl and Toll-9

DIOPT Version :9

Sequence 1:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	116/569 - (20%)
Similarity:	205/569 - (36%)	Gaps:	173/569 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ANKLNADTNIDLKITHSQL---DDLEMRSFTDMNFNLYKLRMQWNSLKSLPEVPFRGL----SNV 111
            |:||..|      ::|..|   .||...:.......:::..:...:..:|...|||.|    .::
  Fly    99 AHKLYLD------LSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESL 157

  Fly   112 TYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLD-RG 175
            ..||:..|:..|:...|                      |||   .|..|       .:||: ..
  Fly   158 KLLSLRGNNFAELIPDA----------------------EDF---ARFVN-------ESRLEASN 190

  Fly   176 SFPK--SLLILHLGRNQLESLNGSLHDLHNLESLFINANNITSLDDELPDG-GQLRLLMAHNNRL 237
            |.|.  .||:||           :..||::.| .::..||.|::...:..| .....:....:|.
  Fly   191 SVPHHCELLLLH-----------NTTDLYDRE-CYLYFNNNTNMGQSITTGRNYTNFIKVLKDRF 243

  Fly   238 ERLPANMAGMHSLETVHIHCNQLRSFDRVLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQM 302
            ::        |...:..|   ...:|.::.|    |.|:...|..:||::::.|.:.|.:..|.|
  Fly   244 DQ--------HGSSSQSI---AWATFPKMPR----LVELDISNCSIEYVSKEAFRNVSNLRRLFM 293

  Fly   303 GCNHIKSLNSSL------LPILKLKNANFSFNDIE------EFSMAELHGLRSLKTLQLSSNRIQ 355
            ..|.|.:::...      :..|.|...||.....:      |.:::.::||:      :..| :.
  Fly   294 SDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALSLIYGLK------IQQN-VF 351

  Fly   356 RLLPDPRGVQELMLVNLDLDNNRIDSLNG-ALAGLGN------------------------LRIL 395
            :.||:        |:.|||.::::...:. |.|.||:                        |..|
  Fly   352 KYLPE--------LIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGL 408

  Fly   396 NLAGNRLEHLQVGD--FDGMI-----------------------RLDILDLTGNQLAELKPLEMT 435
            :|:||......:.|  |||:.                       .|.:|.|.||.:..|.|....
  Fly   409 DLSGNPYLSYNIIDDAFDGIANTLKYLYFERSNIKDLEWSKSLKNLQVLGLAGNNINALTPAMFQ 473

  Fly   436 LLPSLKILKVAYNNITK-LEQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLEIHL 499
            .|.||:||.::.|::.. ....|.....|...||.:|.|:.:|:|::.:....::       :.|
  Fly   474 SLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDY-------LSL 531

  Fly   500 DDNPIMCDVGLNELCRLMAVQEARIRGRSQCFENDQEVCTVLPMLYNVN 548
            .||..:||      |.|.||.|.      ....|....|:...:.|:.|
  Fly   532 GDNDFICD------CHLRAVVEV------AAANNKDADCSYRLLNYSQN 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	4/23 (17%)
		LRR_8	86..145	CDD:290566	10/62 (16%)
		leucine-rich repeat	87..110	CDD:275380	5/26 (19%)
		leucine-rich repeat	111..134	CDD:275380	5/22 (23%)
		leucine-rich repeat	135..158	CDD:275380	3/22 (14%)
		LRR_8	158..214	CDD:290566	14/58 (24%)
		leucine-rich repeat	159..180	CDD:275380	5/23 (22%)
		leucine-rich repeat	181..203	CDD:275380	6/21 (29%)
		leucine-rich repeat	204..226	CDD:275380	5/22 (23%)
		LRR_RI	226..451	CDD:238064	56/286 (20%)
		leucine-rich repeat	227..249	CDD:275380	1/21 (5%)
		leucine-rich repeat	250..272	CDD:275380	3/21 (14%)
		leucine-rich repeat	273..296	CDD:275380	6/22 (27%)
		leucine-rich repeat	297..315	CDD:275380	4/23 (17%)
		LRR_8	319..402	CDD:290566	22/113 (19%)
		leucine-rich repeat	320..335	CDD:275378	4/20 (20%)
		leucine-rich repeat	344..366	CDD:275380	3/21 (14%)
		leucine-rich repeat	367..391	CDD:275380	7/24 (29%)
		LRR_8	369..426	CDD:290566	22/106 (21%)
		leucine-rich repeat	392..415	CDD:275380	9/47 (19%)
		leucine-rich repeat	416..439	CDD:275380	8/22 (36%)
		LRR_8	438..>479	CDD:290566	12/41 (29%)
		leucine-rich repeat	440..462	CDD:275380	5/22 (23%)
		leucine-rich repeat	463..483	CDD:275380	7/19 (37%)
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	10/59 (17%)
		LRR_8	262..322	CDD:290566	14/63 (22%)
		leucine-rich repeat	264..287	CDD:275380	6/22 (27%)
		leucine-rich repeat	288..311	CDD:275380	4/22 (18%)
		leucine-rich repeat	312..356	CDD:275380	9/50 (18%)
		LRR_8	<344..387	CDD:290566	12/57 (21%)
		leucine-rich repeat	357..381	CDD:275380	8/23 (35%)
		leucine-rich repeat	382..397	CDD:275380	0/14 (0%)
		leucine-rich repeat	405..430	CDD:275380	9/24 (38%)
		LRR_8	431..488	CDD:290566	13/56 (23%)
		leucine-rich repeat	432..453	CDD:275380	0/20 (0%)
		LRR_RI	<449..536	CDD:238064	24/93 (26%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		LRR_8	477..536	CDD:290566	16/65 (25%)
		leucine-rich repeat	478..501	CDD:275380	5/22 (23%)
		leucine-rich repeat	502..525	CDD:275380	7/22 (32%)
		TIR	751..891	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930